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作者：Gladkov, Nikita; Pak, Igor; Zimin, Aleksandr
作者单位：University of California System; University of California Los Angeles; Massachusetts Institute of Technology (MIT)
摘要：We give an explicit counterexample to the bunkbed conjecture introduced by Kasteleyn in 1985. The counterexample is given by a planar graph on 7,222 vertices and is built on the recent work of Hollom (2024).
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作者：Li, Junhui; Cui, Zhicheng; Gong, Hongyu; Zhang, Yan; Yuan, Zhenlin; Zhang, Zihao; Ma, Zengyi; Zhou, Nan; Huang, Chuanxin; Zhao, Yao; Li, Xia; Zhang, Zhi; Sun, Yao
作者单位：Tongji University; Tongji University; Tongji University; Tongji University; Fudan University; Inner Mongolia University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Fudan University; Fudan University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Henan University
摘要：Periodontitis, a prevalent chronic inflammatory disease, profoundly impacts both quality of life and overall health. Clinical studies have suggested a correlation between periodontitis and sleep deficiency, but the underlying mechanisms involved remain elusive. Here, we observed an elevated risk of periodontitis in individuals with sleep deficiency, as demonstrated in both clinical subjects and mouse models. Retrograde tracing from the periodontium revealed a neural connection from trigeminal ...
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作者：Hu, Chenyang; Chen, Zhenshan; Liu, Pengfei; Zhang, Wei; He, Xi; Bosch, Darrell
作者单位：Virginia Polytechnic Institute & State University; University of Rhode Island
摘要：As the renewable energy transition continues into less receptive communities, local opposition is expected to intensify, potentially slowing the process. Since the local impacts are neither well quantified nor widely recognized, we lack policies and common practices to mitigate the potential associated welfare loss in affected communities. Based on a nationwide dataset combining property transactions and large-scale solar photovoltaic (LSSPV) sites, we analyze the heterogeneous effects of LSSP...
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作者：Lin, Yu-Chi; Zhao, Yan; Zhang, Yan-Lin; Hong, Yihang; Hattori, Shohei; Itahashi, Syuichi; Fan, Mei-Yi; Xie, Feng; Zhao, Zhu-Yu; Yu, Mingyuan; Cao, Fang; Xu, Rongshuang; Li, Jianghanyang; Kawamura, Kimitaka; Thiemens, Mark H.
作者单位：Nanjing University of Information Science & Technology; Nanjing University of Information Science & Technology; Nanjing University; Nanjing University; Kanazawa University; Kyushu University; University of Colorado System; University of Colorado Boulder; National Oceanic Atmospheric Admin (NOAA) - USA; Chubu University; University of California System; University of California San Diego
摘要：Reduction of China's SO2 emissions has been found to nonlinearly decrease the atmospheric sulfate (SO42-) aerosol concentrations in East Asia. Compared to Europe and North America, the lower effectiveness of SO42-reduction in East Asia suggested much effects of acidity-sensitive feedback mechanisms in this high anthropogenic emission region, which have not been yet examined. In this work, we investigated these feedback mechanisms in East Asia through long-term measurements of the mass-independ...
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作者：Qiu, Caihao; Srolovitz, David J.; Rohrer, Gregory S.; Han, Jian; Salvalaglio, Marco
作者单位：City University of Hong Kong; University of Hong Kong; University of Hong Kong; Carnegie Mellon University; Technische Universitat Dresden; Technische Universitat Dresden
摘要：Grain growth in polycrystals is traditionally considered a capillarity-driven process, where grain boundaries (GBs) migrate toward their centers of curvature (i.e., mean curvature flow) with a velocity proportional to the local curvature (including extensions to account for anisotropic GB energy and mobility). Experimental and simulation evidence shows that this simplistic view is untrue. We demonstrate that the failure of the classical mean curvature flow description of grain growth mainly or...
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作者：Saito, Shinta; Suzuki, Tetsuya; Nohmi, Takehiko; Adachi, Noritaka
作者单位：Yokohama City University; Hiroshima University; National Institute of Health Sciences - Japan
摘要：Efficient targeted integration (TI) of homologous donor DNA is crucial for precise genome editing. Although mismatch repair (MMR) is known to suppress TI as well as homologous recombination (HR) when sequence divergence is present, it remains controversial as to whether MMR affects TI of isogenic donor DNA. In this study, we investigated whether and how the MMR protein Msh2 affects TI of isogenic donor DNA. We found that HR-dependent TI is suppressed by Msh2 only when a homology arm of donor D...
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作者：Wang, Datao; Ba, Hengxing; Li, Xunsheng; Castillejos, Tomas Landete -; Shi, Wanwan; Wang, Zhen; Ren, Jing; Sun, Hongmei; Chonco, Louis; Ma, Chao; Zhang, Guokun; Melino, Gerry; Shi, Yufang; Li, Chunyi
作者单位：Chinese Academy of Agricultural Sciences; Institute of Special Animal & Plant Sciences, CAAS; Jilin Agricultural University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Investigacion en Recursos Cinegeticos (IREC); Universidad de Castilla-La Mancha; University of Rome Tor Vergata; Soochow University - China
摘要：Antlers, a male deer secondary sex characteristic, are unique mammalian appendages that fully regenerate annually, under androgen regulation. Stem cells located in the antlerogenic periosteum (AP), a tissue overlaying the frontal crest of both male and female deer, play a crucial role in antlerogenesis. Nonetheless, the underlying molecular mechanisms as to how antlerogenesis is regulated by androgens remain largely unexplored. Here, we show that androgens regulate antler growth via macrophage...
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作者：Zoeller, Nikolas; Berger, Julian; Lin, Irving; Fu, Nathan; Komarneni, Jayanth; Barabucci, Gioele; Laskowski, Kyle; Shia, Victor; Harack, Benjamin; Chu, Eugene A.; Trianni, Vito; Kurvers, Ralf H. J. M.; Herzog, Stefan M.
作者单位：Max Planck Society; University of Cologne; Claremont Colleges; Harvey Mudd College; University of Oxford; Kaiser Permanente; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze e Tecnologie della Cognizione (ISTC-CNR); Technical University of Berlin
摘要：AI systems, particularly large language models (LLMs), are increasingly being employed in high-stakes decisions that impact both individuals and society at large, often without adequate safeguards to ensure safety, quality, and equity. Yet LLMs hallucinate, lack common sense, and are biased-shortcomings that may reflect LLMs' inherent limitations and thus may not be remedied by more sophisticated architectures, more data, or more human feedback. Relying solely on LLMs for complex, high-stakes ...
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作者：Hirokawa, Soichi; Lee, Heun Jin; Banks, Rachel A.; Duarte, Ana I.; Najma, Bibi; Thomson, Matt; Phillips, Rob
作者单位：California Institute of Technology; California Institute of Technology; California Institute of Technology; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS)
摘要：A hallmark feature of active matter systems is the ability of individual elements to interact and organize over length scales exceeding that of the constituent molecular players. However, the nature of internal redistribution that occurs in the bulk of the collective is less clear. Using light-dimerizable kinesin motors to spatially control the formation and contraction of a microtubule network, we deliberately photobleach a grid pattern onto the filament network serving as a transient and dyn...
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作者：Day, Trevor A.; Bigham, Abigail W.; Brutsaert, Tom D.
作者单位：Mount Royal University; University of California System; University of California Los Angeles; Syracuse University
