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作者：Kina, Hirono; Izumi, Natsuko; Hanyu-Nakamura, Kazuko; Yoshitani, Takashi; Yamane, Mariko; Niwa, Hitoshi; Tomari, Yukihide; Nakamura, Akira
作者单位：Kumamoto University; Kumamoto University; University of Tokyo; Kumamoto University; Kumamoto University; RIKEN; Institute of Science Tokyo; University of Tokyo
摘要：Germ cells transmit genetic information to offspring and maintain the genome of the species. In many animals including Drosophila, germ cell formation relies on maternal determinants in the germ plasm. Several proteins present in the germ plasm of oocytes also localize to the perinuclear nuage in nurse cells, where they contribute to the production of PIWI-interacting RNAs (piRNAs). These piRNAs guide the silencing of transposons, thereby protecting the germline genome from invading mobile ele...
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作者：Xu, Yun-Yu; Jiang, Xue-Lian; Chai, Jia-Lu; Qiu, Shu-Juan; He, Juan; Xu, Gan; Wei, Jia; Yu, Qiu-Xiang; Zhang, Hong-Ying; Li, Yue; Zhang, Xiao-Wen; Cao, Guo-Liang; Li, Yong; Cui, Yun-Shu; Xu, Cong-Qiao; Li, Jun; Chen, Xu-Dong
作者单位：Nanjing Normal University; Southern University of Science & Technology; Southern University of Science & Technology; Chinese Academy of Sciences; Ganjiang Innovation Academy, CAS; Tsinghua University; Tsinghua University; Nanjing University
摘要：The FeMo cofactor (FeMoco), the key active site in the Mo- based nitrogenase, is one of the most complicated metalloenzyme molecules. Synthesis of the FeMoco model cluster ([MoFe7S9C]) is essential to understanding its function in dinitrogen binding, activation, and conversion. However, the complex framework of the FeMoco cluster, which features a unique trigonal prismatic [Fe6C] moiety comprising a mu 6- bridging carbide, has made the synthesis of the cluster a persistent challenge. In this w...
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作者：Rasoamalala, Fanohinjanaharinirina; Ramasindrazana, Beza; Parany, Mamionah J.; Rahajandraibe, Soloandry; Randriantseheno, Lovasoa; Rahelinirina, Soanandrasana; Gorge, Olivier; Valade, Eric; Harimalala, Mireille; Rajerison, Minoarisoa; Cauchemez, Simon; Brault, Antoine
作者单位：Pasteur Network; Institut Pasteur Madagascar; University Antananarivo; Pasteur Network; Institut Pasteur Madagascar; Institut National de la Sante et de la Recherche Medicale (Inserm); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS)
摘要：Plague continues to pose a public health problem in multiple regions of the world, including Madagascar, where it is characterized by a pronounced seasonal pattern. The drivers of plague seasonality remain poorly understood. Using a deterministic compartmental model, calibrated to rat and flea capture data, serological data collected in active rural foci, and human plague surveillance data, we analyzed the effects of seasonal rat and flea population dynamics on plague transmission. The models ...
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作者：Weiner, Benjamin G.; Markle, Hanna; Laderman, Eric; Demirjian, Choghag; Bergelson, Joy
作者单位：United States Department of Energy (DOE); New York University
摘要：Effector-Triggered Immunity (ETI) is an important part of the plant immune system, allowing plants to sense and respond to harmful pathogen proteins known as effectors. Effectors can be sensed directly or indirectly by NLR (Nucleotide-binding Leucine-rich Repeat) proteins, many of which guard the plant proteins targeted by effectors. Although a few effector-target-NLR interactions have been characterized, a general understanding of how these molecular interactions give rise to a functioning im...
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作者：Xygalatas, Dimitris; Profeta, Vitor Leandro da Silva; Saraei, Mohammadamin; Baranowski-Pinto, Gabriela
作者单位：University of Connecticut; University of Connecticut; Universidade Federal de Minas Gerais; Universidade do Estado de Minas Gerais
摘要：Sporting events are powerful social phenomena that extend beyond the game itself, offering a unique lens to study collective emotional dynamics. We examine emotional alignment among football fans during a high-stakes match in Brazil, focusing on both the game and the preceding Rua de Fogo, a pregame ritual marked by chants, flares, and collective anticipation. Using wearable electrocardiographic (ECG) sensors to monitor heart rate patterns, we apply multidimensional recurrence quantification a...
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作者：Zeng, Wanwen; Guo, Hanmin; Liu, Qiao; Wong, Wing Hung
作者单位：Stanford University; Stanford University; Stanford University; Stanford University
摘要：Polygenic risk scores (PRS) are essential tools for estimating individual susceptibility to complex diseases by aggregating the effects of many genetic variants. With the advent of whole-genome sequencing (WGS), rare and de novo variants can now be detected at scale, presenting new opportunities to enhance PRS performance. Additionally, regulatory mechanisms that govern gene expression play a critical role in disease manifestation, suggesting further potential for improvement. However, most ex...
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作者：Colquhoun, Jennifer M.; Brzezinski, Carter U.; Ji, Andrew; Marotta, Julianna; Elsen, Franziska A. V.; Bonomo, Robert A.; May, Kerrie L.; Sieber, Stephan A.; Grabowicz, Marcin; Wuest, William M.; Rather, Philip N.
作者单位：US Department of Veterans Affairs; Veterans Health Administration (VHA); Atlanta VA Medical Center; Atlanta VA Health Care System; Emory University; Emory University; Emory University; Emory University; Technical University of Munich; University System of Ohio; Case Western Reserve University; US Department of Veterans Affairs; Veterans Health Administration (VHA); Louis Stokes Cleveland Veterans Affairs Medical Center; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University
摘要：The OXA (3-lactamases in Acinetobacter baumannii represent a primary mechanism for resistance to the carbapenems, a class of antibiotics that represent a last line for treatment. In a screen of an U.S. Food and Drug Administration (FDA)-approved drug library, we identified fendiline, a calcium channel blocker, had significantly more antimicrobial activity against OXA-23 expressing cells. Genetic and proteomic studies revealed that fendiline inhibited the essential lipoprotein trafficking pathw...
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作者：Jeong, Seung Gyo; Lee, Seungjun; Lin, Bonnie; Yang, Zhifei; Choi, In Hyeok; Oh, Jin Young; Song, Sehwan; Lee, Seung wook; Nair, Sreejith; Choudhary, Rashmi; Parikh, Juhi; Park, Sungkyun; Choi, Woo Seok; Lee, Jong Seok; Lebeau, James M.; Low, Tony; Jalan, Bharat
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Massachusetts Institute of Technology (MIT); University of Minnesota System; University of Minnesota Twin Cities; Gwangju Institute of Science & Technology (GIST); Sungkyunkwan University (SKKU); Pusan National University
摘要：The anomalous Hall effect (AHE), a hallmark of time-reversal symmetry breaking, has been reported in rutile RuO2, a debated metallic altermagnetic candidate. Previously, AHE in RuO2 was observed only in strain-relaxed thick films under extremely high magnetic fields (similar to 50 T). Yet, in ultrathin strained films with distinctive anisotropic electronic structures, there are no reports, likely due to disorder and defects suppressing metallicity thus hindering its detection. Here, we demonst...
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作者：Rufin, Philippe; Meyfroidt, Patrick; Akinyemi, Felicia O.; Estes, Lyndon; Ibrahim, Esther Shupel; Jain, Meha; Kerner, Hannah; Lisboa, Sa Nogueira; Lobell, David; Nakalembe, Catherine; Persello, Claudio; Picoli, Michelle C. A.; Ribeiro, Natasha; Sitoe, Almeida Alberto; Waha, Katharina; Wang, Sherrie
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作者：Caobi, Allen; Su, Chia - Ming; Beusch, Christian M.; Kenney, Devin; Darling, Tamarand L.; Feng, Shuchen; Semaan, Marc; Wacquiez, Alan; Sanders, Nathan L.; Tully, Ena S.; Chen, Da - Yuan; Evdokimova, Monika; Ding, Zhen; Jones, Dakota; Alysandratos, Konstantinos - Dionysios; Mizgerd, Joseph P.; Kirchdoerfer, Robert N.; Kotton, Darrell N.; Douam, Florian; Crossland, Nicholas A.; Boon, Adrianus C. M.; Gordon, David E.; Baker, Susan C.; Saeed, Mohsan
作者单位：Boston University; Boston University; Emory University; Uppsala University; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Loyola University Chicago; Boston University; Boston University; University of Wisconsin System; University of Wisconsin Madison; Boston University; Boston Medical Center; Boston University; Boston University
摘要：SARS-CoV-2 encodes numerous virulence factors, yet their precise mechanisms of action remain unknown. We provide evidence that the SARS-CoV-2 nonstructural protein 15 (nsp15) enhances viral virulence by suppressing the production of viral double-stranded (dsRNA), a potent inducer of antiviral signaling. The viral variants lacking nsp15 endoribonuclease activity elicited higher innate immune responses and exhibited reduced replication in human stem cell-derived lung alveolar type II epithelial ...
