24期

最新文章

• Oscillatory redox behavior in oxides: Cyclic surface reconstruction and reactivity modulation via the Mars-van Krevelen mechanism AI翻译
  作者：Sun, Xianhu; Wu, Dongxiang; Wang, Jianyu; Patel, Shyam B.; Zhu, Wenhui; Yang, Ji; Yang, Timothy T.; Ye, Shuonan; Chen, Xiaobo; Zhu, Yaguang; Qiao, Linna; Li, Meng; House, Stephen D.; Su, Ji; Saidi, Wissam A.; Boscoboinik, Jorge Anibal; Yang, Judith C.; Sharma, Renu; Zhou, Guangwen
  作者单位：State University of New York (SUNY) System; Binghamton University, SUNY; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; United States Department of Energy (DOE); Brookhaven National Laboratory; National Institute of Standards & Technology (NIST) - USA
  摘要：The breaking of translational symmetry at oxide surfaces gives rise to coordinatively unsaturated cations/anions and surface restructuring-key factors that govern surface reactivity. Using direct in situ environmental transmission electron microscopy (TEM) observations along with atomistic modeling, we report oscillatory redox behavior in CuO under H2, where cyclic surface reconstruction and reactivity modulation occur via the Mars-van Krevelen (MvK) mechanism. We observe self-switching betwee...
• A synthetic jasmonate receptor agonist uncouples the growth-defense trade-off in rice AI翻译
  作者：Xiao, Junli; Nakamura, Yoko; Wu, Zhixin; Fu, Wenjie; Chen, Yumeng; Lou, Yonggen; Baldwin, Ian T.; Boland, Wilhelm; Li, Ran
  作者单位：Zhejiang University; Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society
  摘要：Herbivore attack elicits jasmonate (JA) signaling which in turn elicits both anti-herbivore plant defenses and growth inhibitions. The resulting growth-defense trade-offs constrain the utility of JA-based plant defense inducers to enhance endogenous pest resistance. Here, we designed and screened selective JA receptor agonists by synthesizing 6-substituted 1-oxoindanoyl isoleucine (In-Ile) conjugates and their free-acid forms, structural mimics of the bioactive hormone (+)-7-iso-jasmonoyl-L-Il...
• Eradication efforts catalyze rapid evolution in an invasive predatory fish AI翻译
  作者：Zarri, Liam J.; Kraft, Clifford E.; Mcintyre, Peter B.; Baetscher, Diana S.; Jirka, Kurt J.; Randall, Eileen A.; Quay, Benjamin Marcy -; St John, Carl A.; Sethi, Suresh A.; Airey, Montana E.; Detmer, Thomas M.; Flecker, Alexander S.; Therkildsen, Nina O.
  作者单位：Cornell University; Cornell University; National Oceanic Atmospheric Admin (NOAA) - USA; United States Department of the Interior; United States Geological Survey; City University of New York (CUNY) System; Brooklyn College (CUNY)
  摘要：Species invasions spur costly and labor-intensive control efforts, yet even local eradication is seldom achieved. When control measures are initially effective, they may drive evolutionary adaptation that prevents full eradication, as has been documented for some chemical and biocontrol approaches. Although the intensity, directionality, and persistence of selection required to increase the frequency of resistant genotypes in complex natural ecosystems remains an open question, theory predicts...
• Acquired resistance to immunotherapy by physical barriers with cancer cell-expressing collagens in non-small cell lung cancer AI翻译
  作者：Wang, Manli; Wang, Yiyun; Pan, Xiangyu; Wang, Bo; Wang, Yuying; Luo, Xiangmeng; Deng, Xiaofeng; Liu, Li; Chen, Xuelan; Zhai, Xiaoqian; Wu, Baohong; Zhang, Qi; Ren, Yifeng; Li, Jia; Li, Xiaoyu; Cao, Fujun; Yang, Yang; Deng, Xintong; Li, Runhong; Lu, Zhenghao; Tan, Ping; Chen, Jingyao; Li, Yan; Liu, Yanyang; Liu, Jiewei; Wang, Yuan; Deng, Hongxin; Su, Zhaoming; Wang, Weiya; Wang, Yongsheng; Yang, Shengyong; Zhao, Chengjian; Xue, Jianxin; Wei, Yuquan; Zhang, Kang; Na, Feifei; Liu, Yu; Chen, Chong
  作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University; Chengdu University of Traditional Chinese Medicine; Chengdu University of Traditional Chinese Medicine; Sichuan University; Sichuan University; Macau University of Science & Technology; Sichuan University; Sichuan University; Tianfu Jincheng Laboratory; Sichuan University
  摘要：Immunotherapy has become the standard treatment for many types of cancers, but an increasing number of patients who initially respond to these treatments develop acquired immunotherapy resistance (AIR). Here, we recapitulated the entire process of immunotherapy from response to AIR in mice with non-small cell lung cancer (NSCLC). With implanted tumor organoids derived from these models and serial transplants, we demonstrated that tumor cell-intrinsic mechanisms contributed significantly to AIR...
• QnAs with David B. Lobell AI翻译
  作者：Williams, Sarah C. P.
• Keratinocyte-TRPV 1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch AI翻译
  作者：Crowther, Andrew J.; Kashem, Sakeen W.; Jewell, Madison E.; Le Chang, Henry; Midavaine, Elora; Casillas, Mariela Rosa; Danchine, Veronika; Rodriguez, Sian; Kania, Artur; Chen, Ritchie; Braz, Joao M.; Basbaum, Allan I.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; University of California System; University of California San Francisco
  摘要：Our understanding of neural circuits that respond to skin dysfunction, triggering itch, and pathophysiological scratching remains incomplete. Here, we describe a profound chronic itch phenotype in transgenic mice expressing the tetracycline transactivator (tTA) gene within the Phox2a lineage. Phox2a; tTA mice exhibit intense, localized scratching and regional skin lesions, controllable by the tTA inhibitor, doxycycline. As gabapentin and the kappa opioid receptor agonist, nalfurafine, but not ...
• N6-methyladenosine modification of HCMV IE1 transcript promotes the repressive state of viral genome to achieve latent infection AI翻译
  作者：Jeong, Heena; Yeo, Nagyeong; Hwang, Hyeonseo; Park, Junhyun; Baek, Daehyun; Ahn, Kwangseog
  作者单位：Seoul National University (SNU); Institute for Basic Science - Korea (IBS); Seoul National University (SNU)
  摘要：Human cytomegalovirus (HCMV) is a prevalent pathogen that chronically infects the majority of human population. Among the many features that allow such widespread HCMV infection, one is its ability to maintain a transcriptionally dormant immune-evasive state called latency by suppressing its own major immediate early promoter (MIEP) via epigenetic alterations. In this study, we show a mechanism of MIEP regulation in which the major immediate early (MIE) gene product, immediate early 1 (IE1) tr...
• Enzymatic carbon-fluorine bond cleavage by human gut microbes AI翻译
  作者：Probst, Silke I.; Felder, Florian D.; Poltorak, Victoria; Mewalal, Ritesh; Blaby, Ian K.; Robinson, Serina L.
  作者单位：Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Swiss Federal Institutes of Technology Domain; ETH Zurich; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：Fluorinated compounds are used for agrochemical, pharmaceutical, and numerous industrial applications, resulting in global contamination. In many molecules, fluorine is incorporated to enhance the half-life and improve bioavailability. Fluorinated compounds enter the human body through food, water, and xenobiotics including pharmaceuticals, exposing gut microbes to these substances. The human gut microbiota is known for its xenobiotic biotransformation capabilities, but it was not previously k...
• Dismantling EPA's research office jeopardizes environmental safety, public health, and US competitiveness AI翻译
  作者：Glaberman, Scott; Frey, H. Christopher; Tal, Tamara
  作者单位：University of Birmingham; North Carolina State University; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ)
• Ligand- specific regulation of a binary enhancer code dictating cellular senescence AI翻译
  作者：Suter, Thomas; Friedman, Meyer J.; Tazearslan, Cagdas; Merkurjev, Daria; Ohgi, Kenny; Meluzzi, Dario; Rosenfeld, Michael G.; Suh, Yousin
  作者单位：University of California System; University of California San Diego; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Columbia University; NewYork-Presbyterian Hospital; NewYork-Presbyterian Hospital; Columbia University
  摘要：Cellular senescence, a major contributor to aging and age-related pathologies, is characterized by irreversible proliferative arrest and a disease-linked, proinflammatory profile known as the Senescence Associated Secretory Phenotype (SASP). A critical unanswered question is whether these properties are regulated by specific enhancer subsets, potentially licensing strategies that selectively block deleterious SASP components. Here, we identify two functionally distinct and independently regula...