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最新文章

• RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ AI翻译
  作者：Jiang, Hui; Yun, Hongfang; Wang, Xu; Shen, Zhuo; Liu, Genyu; Zou, Tao; Guo, Tingting; Wu, Mengyao; Lu, Yuchen; Deng, Lijiao; Miao, Ju; Deng, Hongbin; Yuan, Zengqiang; Zhang, Jiyan
  作者单位：Academy of Military Medical Sciences - China; Institute of Basic Medical Sciences (IBMS); University of South China; Anhui Medical University; Henan University; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Medicinal Biotechnology - CAMS; Peking Union Medical College; Chinese Institute for Brain Research, Beijing
  摘要：Alveolar macrophages (AMs) are indispensable to prevent pulmonary alveolar proteinosis and clear inhaled pathogens. Receptor for activated C kinase 1 (RACK1) is a versatile adaptor protein that regulates multiple signaling pathways. Whether RACK1 is implicated in AM alterations remains elusive. Alveolar type 2 cells-derived granulocyte-macrophage colony-stimulating factor and autocrine transforming growth factor-(31 drive the transcription of Pparg, the gene encoding AM signature transcription...
• Spatiotemporal regulation of target mRNA cleavage by 21-nt phasiRNAs in maize anthers AI翻译
  作者：Lian, Bi; Huang, Tianxiao; Huang, Wei; Jiang, Pengfei; Jin, Weiwei; Qi, Yijun
  作者单位：Tsinghua University; China Agricultural University; Anhui Agricultural University; Peking University; Tsinghua University; Tsinghua University
  摘要：21-nt phasiRNAs are abundantly expressed in anthers and play crucial roles in anther development and male reproduction in grasses. In maize, the target genes that 21-nt phasiRNAs regulate remain largely unknown. Here, we show that 21-nt phasiRNAs direct the cleavage of hundreds of target mRNAs in maize. Interestingly, while 21-nt phasiRNAs in anthers (somatic anther wall cells) do not have obvious preference for a particular nucleotide at the 5 ' end and target genes implicated in stress respo...
• The pumping function of sponge choanocyte chambers AI翻译
  作者：Larsen, Paul S.; Riisgard, Hans Ulrik
  作者单位：Technical University of Denmark; University of Southern Denmark
• The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant AI翻译
  作者：Gonzalez-Delgado, Javier; Mier, Pablo; Bernado, Pau; Neuvial, Pierre; Cortes, Juan
  作者单位：Universite de Rennes; Ecole Nationale de la Statistique et de l'Analyse de l'Information (ENSAI); Centre National de la Recherche Scientifique (CNRS); Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology (CABD); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Centre National de la Recherche Scientifique (CNRS)
  摘要：The correlation between synonymous codon usage and secondary structure in translated proteins has been widely demonstrated. This usage plays a capital role in tuning translational rates and protein folding kinetics, indirectly influencing multiple Nat. Commun. 13, 2815 (2022).] suggests that the translated synonymous codon influences the (tp, ) dihedral angles within secondary structure elements. If true, this conclusion would have strong consequences in several scientific fields, including st...
• The CARD14sh-BCL10-MALT 1 complex regulates MAVS- mediated antiviral response in keratinocytes AI翻译
  作者：Zerillo, Lucrezia; Zotti, Tiziana; Tutela, Angelapia; Madera, Jessica Raffaella; Grasso, Gabriella; Vito, Pasquale; Stilo, Romania
  作者单位：University of Sannio
  摘要：The Mitochondrial Antiviral Signaling Protein (MAVS) is a key adaptor in antiviral immunity, mediating type I interferon responses downstream of RIG1 and TLR3. While MAVS regulation is essential for antiviral defense, its modulation in keratinocytes is poorly understood. Here, we examine the role of the CARD14-BCL10-MALT1 (CBM) complex, a skin-specific signaling module, in controlling MAVS-dependent antiviral responses. We identify CARD14short as a dual regulator that activates NF-kappa B whil...
• A unifying principle for multispecies coexistence under resource fluctuations AI翻译
  作者：Richardson, James A.; Engelstaedter, Jan; Letten, Andrew D.
  作者单位：University of Queensland
  摘要：Resource fluctuations are ubiquitous in nature and yet are generally assumed to play a limited role in the maintenance of biodiversity. We challenge this assumption by analyzing resource competition dynamics under conditions where prevailing theory does not hold. We show that multispecies coexistence can be sustained when species are able to specialize on different temporal patterns of resource variability, including the asymmetries and periodic extremes commonly observed in natural systems. W...
• Reflection and refraction of directrons at the interface AI翻译
  作者：Tang, Xing-Zhou; Li, Chao-Yi; Huang, Zhi-Jun; Zhao, Jia-Hui; Chen, Yu-Xi; Abbott, Nicholas L.; de Pablo, Juan J.; Lu, Yan-Qing; Li, Bing-Xiang
  作者单位：Nanjing University of Posts & Telecommunications; Nanjing University of Posts & Telecommunications; University of Chicago; Nanjing University; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Cornell University; United States Department of Energy (DOE); Argonne National Laboratory; New York University; New York University Tandon School of Engineering
  摘要：Reflection and refraction are ubiquitous phenomena with extensive applications, yet minimizing energy loss and information distortion during these processes remains a significant challenge. This study examines the behavior of structurally stable solitons, known as directrons, in nematic liquid crystals interacting with an interface where the director field orientation changes, despite identical physical properties, external potentials, and boundary anchoring in the two regions. During reflecti...
• Carbon and oxygen isotope evidence for a protoplanetary disk origin of organic solids in meteorites AI翻译
  作者：Lawrence, William M.; Blake, Geoffrey A.; Eiler, John
  作者单位：California Institute of Technology
  摘要：Macromolecular organic solids found in primitive meteorites were the main source of carbon delivered to forming planets in the early Solar System. However, the conditions under which this material formed and its subsequent incorporation into growing planetesimals remains a subject of vigorous debate. Here, we show that C isotope variations among these organics in most carbonaceous chondrites are strongly correlated with mass-independent O isotope anomalies exhibited by their host meteorites. A...
• Reply to Larsen and Riisgård: Fluid dynamics of choanocyte chambers AI翻译
  作者：Ogawa, Takumi; Koyama, Shuji; Omori, Toshihiro; Kikuchi, Kenji; de Maleprade, Helene; Goldstein, Raymond E.; Ishikawa, Takuji
  作者单位：Tohoku University; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; University of Cambridge; Tohoku University
• An N- terminal domain specifies developmental control by the SMAX1-LIKE family of transcriptional regulators in Arabidopsis thaliana AI翻译
  作者：Chang, Sun Hyun; George, Wesley J.; Nelson, David C.
  作者单位：University of California System; University of California Riverside
  摘要：SMAX1-LIKE (SMXL) proteins in plants are cellular signaling hubs, many of which are posttranslationally regulated by karrikins from smoke, the plant hormones strigolactones (SLs), and/or cues such as light and nutrients. SMXL proteins control diverse aspects of growth, development, and environmental adaptation in plants through transcriptional corepression and interactions with transcriptional regulator proteins. In flowering plants, the SMXL family comprises four phylogenetic clades with diff...