24期

最新文章

• CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity AI翻译
  作者：Rodriguez, Marcelo M.; Chatterjee, Debashree; Guerry, Johanna; Patenaude, Anne - Marie; Cohen, Charles C. H.; Bois, Therence; Larouche, Ariane; Ferreira, Silvana R.; Bertomeu, Thierry; Aryamontri, Andrew; Zhang, Li; Mader, Sylvie; Nislow, Corey; Jean, Guillaume; Guindon, Yvan; Zahn, Astrid; Noia, Javier M. Di
  作者单位：Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; Universite de Montreal; Universite de Montreal; University of British Columbia; Universite de Montreal; Universite de Montreal; Universite de Montreal; Universite de Montreal; University of Vienna
  摘要：Cancer therapy is limited by resistance to standard-of-care chemotherapeutic and/or by treatment-associated toxicity. Identifying molecular mechanisms that modulate cellular toxicity is crucial for enhancing treatment efficacy. We characterize CDADC1, a vertebrate-specific orphan enzyme, as an unprecedented eukaryotic dCTP deaminase. CDADC1 catalyzes the conversion of dCTP into dUTP. While bacteria use this activity to sustain proliferation, CDADC1 evolved independently and is not required for...
• Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age- related macular degeneration pathology AI翻译
  作者：Wang, Ying; Zhang, Yi-Chen; Ding, Zi-Qin; Xu, Shi-Yao; Zhang, Ye-Ran; Zhu, Hong-Jing; Huang, Chang; Wang, Jia-Nan; Zhu, Meidong; Ji, Jiang-Dong; Yan, Biao; Liu, Qing-Huai; Chen, Xue
  作者单位：Nanjing Medical University; Fudan University; Fudan University; University of Sydney; Shanghai Jiao Tong University
  摘要：Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly. It is characterized by degeneration of the retinal pigment epithelium (RPE), which can develop into choroidal neovascularization (CNV) to cause severe and rapid vision loss. Preventing this progression might help save vision, but the exact mechanisms remain unclear. In this study, using clinical AMD samples and the gene knockout mice, we reported that the m1A eraser ALKBH3 reshaped retinal metabolism to p...
• Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders AI翻译
  作者：Miotto, Marco C.; Luna-Figueroa, Estefania; Tchagou, Carl; Bahlouli, Laith; Reiken, Steven; Dridi, Haikel; Liu, Yang; Weninger, Gunnar; Marks, Andrew R.
  作者单位：Columbia University; Columbia University
  摘要：Ryanodine receptors (RyRs) are intracellular Ca2+ channels essential for muscle contraction. Caffeine, a xanthine derivative, has been known for decades to increase muscle contraction and enhance activation of RyRs by increasing the sensitivity to Ca2+. We previously showed that xanthine, the only physiologically relevant xanthine derivative, also binds to and activates RyR2. Most xanthine derivatives and analogs are safe and widely prescribed, with the most popular being the xanthine oxidored...
• Equilibrium-gated pattern formation: How molecular dissociation thermodynamics drive emergent behavior in dissipative polymeric systems AI翻译
  作者：Bistri, Donald; Cramblitt, Anna; Arretche, Ignacio; Zhang, Conan; Cope, Reid B.; Zakoworotny, Michael; Mills, Mya G.; Koett, Luis E. Rodriguez; Chua, Lauren; Gomez-Bombarelli, Rafael; Tawfick, Sameh H.; Sottos, Nancy R.; Moore, Jeffrey S.; Geubelle, Philippe H.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Massachusetts Institute of Technology (MIT)
  摘要：Emergent patterns in biological systems arise through dissipative processes that balance reaction and transport phenomena, producing highly functional properties from self-regulating mechanisms. Synthetic fabrication, by contrast, often relies on user-controlled, multistep methods that lack the self-organizing capabilities of natural systems. Inspired by nature, we sought chemical systems that integrate strongly coupled reaction and transport phenomena, identifying frontal ring-opening metathe...
• Unbalanced social-ecological acceleration led to state formation failure in early medieval Poland (vol 122, e2409056122, 2025) AI翻译
  作者：Izdebski, Adam; Czerwinski, Sambor; Jankowiak, Marek; Danielewski, Marcin; Fiolna, Sabina; Gromig, Raphael; Guzowski, Piotr; Haghipour, Negar; Hajdas, Irka; Kolaczek, Piotr; Lamentowicz, Mariusz; Marcisz, Katarzyna; Niebieszczanski, Jakub; Sankiewicz, Pawel; Wagner, Bernd
• Preacclimatization and base excess rather than deficit? AI翻译
  作者：Kleinsasser, Axel; Burtscher, Martin
  作者单位：Medical University of Innsbruck; University of Innsbruck
• Transglutaminase 2-mediated glutamine deamidation enhances p21 stability during senescence AI翻译
  作者：Liao, Yi-Wen; Hsieh, Hsi-Hsien; Yeh, Jin-Wei; Wang, Hsin-Chiao; Huang, Shang-Yi; Wang, Pei-Yu; Lin, Jing-Jer
  作者单位：National Taiwan University; National Taiwan University; National Taiwan University; National Taiwan University Hospital
  摘要：The limited doubling capacity of human cells, known as replicative senescence or cellular senescence, is a major factor in cellular aging. This process is triggered by telomere proliferation. p53, a transcriptional regulator, responds to DNA damage by increasing the expression of the cyclin- dependent kinase inhibitor p21. p21 then arrests cells at specific stages of the cell cycle. Additionally, p53 upregulates serpinB2 (also known as plasminogen activator inhibitor- 2, PAI- 2), which stabili...
• The great phage escape: Activating and escaping lactococcal antiphage systems AI翻译
  作者：Mosterd, Cas; Grafakou, Andriana; Charneco, Guillermo Ortiz; de Waal, Paul P.; van Rijswijck, Irma M. H.; van Peij, Noel N. M. E.; Pechoux, Christine; Kulakauskas, Saulius; Cambillau, Christian; Mahony, Jennifer; van Sinderen, Douwe
  作者单位：University College Cork; University College Cork; AgroParisTech; INRAE; Universite Paris Saclay; Universite Paris Saclay; INRAE; AgroParisTech; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
  摘要：In recent years, the number of newly discovered systems that bacteria use to combat bacteriophages is increasing at an impressive rate. To obtain mechanistic insights into several antiphage systems identified in previous studies, we isolated 66 phage escape mutants which had become insensitive to 13 distinct, plasmid- encoded lactococcal phage mutants identified a total of 15 mutated genes. Six of the encoded proteins appear to activate specific antiphage systems. Furthermore, AbiA escape muta...
• Biparental inheritance of germline- specific chromosomes in the sea lamprey and their roles in oocytes AI翻译
  作者：Timoshevskiy, Vladimir A.; Timoshevskaya, Nataliya; Eskut, Kaan I.; Rajandran, Kasturi; Smith, Jeramiah J.
  作者单位：University of Kentucky; University of Kentucky
  摘要：Many eukaryotic species undergo programmed elimination of specific chromosomes during embryogenesis, typically retaining these chromosomes only in their germ cells. In some species, programmatic elimination of GRCs, or sex chromosomes, also occurs in a sex-specific manner, with specific chromosomes being transmitted or eliminated by only one sex. As such, these chromosomes provide a unique perspective on the evolution of gene functions that are advantageous to the germline and genetic tradeoff...
• Dual- laser 808 and 1,064 nm strategy that circumvents the Achilles' heel of photothermal therapy AI翻译
  作者：Ding, Qihang; Liu, Jiqiang; Wang, Yue; Kim, Jungryun; Huang, Zhihui; Lee, Yubin; Zhou, Hui; Zhang, Pengfei; Sessler, Jonathan L.; Kim, Jong Seung
  作者单位：Korea University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Nanjing University of Posts & Telecommunications; University of Texas System; University of Texas Austin
  摘要：Breast cancer has now overtaken lung cancer as the world's leading cancer, yet detecting and implementing effective therapies remains a significant challenge. Substantial advances have been made in photothermal therapy (PTT), where photosensitizers use photonic energy to induce localized hyperthermia for cancer eradication. This pioneering approach is gaining traction in clinical settings. However, traditional PTT faces inherent limitations, including the risk of damage to neighboring healthy ...