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作者：Huang, Xin; Li, Fangxia; Liu, Lin; Li, Yanxia; Zhang, Mengmeng; Ma, Guoming; Gao, Ying; Shan, Bing; Liang, Xiaozhen; Yuan, Junying; Pan, Heling
作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS
摘要：Necroptosis and apoptosis are two alternatively regulated cell death pathways. Activation of RIPK1 upon engagement of TNFR1 by TNF alpha may promote necroptosis by interacting with RIPK3 or apoptosis by activating caspases. RIPK1 is extensively regulated by a variety of dynamic posttranslational modifications which control its kinase activity and formation of downstream complexes to mediate necroptosis and apoptosis. Here, we investigate the functional significance and mechanism by which PARP1...
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作者：Sun, Xiang; Li, Huan; Chen, Zhan- Bo; Liu, Bing- Qi; Li, Chu- Qiao; Zhao, Zheng- Yang; Li, Xing-Ye; Luan, Jun-Bo
作者单位：Shenyang Agricultural University; Shenyang Agricultural University
摘要：Although it is widely recognized that nutritional symbionts can manipulate host reproduction, the underlying molecular and cellular mechanisms are largely unclear. The facultative symbiont Hamiltonella in bacteriocyte induces female-biased sex ratio of whiteflies. Here, we demonstrate that a maternal gene tudor (tud) and its encoded protein have lower expression levels in ovaries of Hamiltonella-cured whiteflies. Tud family proteins can interlink the various stages of biosynthesis of PIWI-inte...
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作者：He, Xiaoqing; Wu, Yi; Shu, Peng; Yin, Yanpeng; Deng, Heng; Ying, Shiyu; Wu, Mengbo; Zhao, Panpan; Huang, Tengbo; Pirrello, Julien; Zhang, Yang; Grierson, Don; Zhong, Zhenhui; Hong, Yiguo; Bouzayen, Mondher; Liu, Mingchun
作者单位：Sichuan University; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Shenzhen University; University of Nottingham; University of Warwick; Hebei Agricultural University
摘要：Improving fruit growth and quality without compromising yield is a highly sought-after goal in crop breeding. Here, we report that an EAR motif-containing transcription factor SlPLT6 controls the onset of fruit ripening and quality traits in tomato. SlPLT6 knockout caused precocious ripening initiation and enhanced fruit qualities without penalizing yield in two tomato cultivars. SlPLT6 represses genes involved in ripening initiation and major quality traits by directly binding to their promot...
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作者：Chu, C. Y. Cyrus; Lin, Chang-Ching; Lu, Shih -Ting; Kao, Ching- Yuan
作者单位：Academia Sinica - Taiwan; National Taiwan University
摘要：In vitro fertilization (IVF) affects human fertility by 1) increasing the probability of multiple births through the transfer of multiple embryos, 2) raising the proportion of dizygotic twins, which leads to a higher occurrence of one-boy-one-girl twins, and 3) enabling gender selection through preimplantation genetic screening (PGS) when parents have specific gender preferences. While the above-mentioned increase in multiple births is well documented, the impact on the twins' gender compositi...
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作者：Mobach, Simon; Bergkamp, Nick D.; Ma, Ziliang; V. Haselager, Marco; Anbuhl, Stephanie M.; Jurriens, Daphne; van den Bor, Jelle; Wang, Ziming; Crudden, Caitrin; Roos, Jamie L.; Almeria, Claudia V. Perez; Boergonje, Rick A.; Lohse, Martin J.; Bosma, Reggie; Eldering, Eric; Siderius, Marco; Wu, Wei; Spaargaren, Marcel; Tonino, Sanne H.; Kater, Arnon P.; Smit, Martine J.; Heukers, Raimond
作者单位：Vrije Universiteit Amsterdam; Utrecht University; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Vrije Universiteit Amsterdam; University of Amsterdam; Utrecht University; Helmholtz Association; Max Delbruck Center for Molecular Medicine; National University of Singapore; University of Amsterdam; Vrije Universiteit Amsterdam
摘要：The chemokine receptor CXCR4 is overexpressed in many cancers and contributes to pathogenesis, disease progression, and resistance to therapies. CXCR4 is known to form oligomers, but the potential functional relevance in malignancies remains elusive. Using nanobody-based BRET method, we demonstrate that oligomerization of endogenous CXCR4 on lymphoid cancer cell lines correlates with enhanced expression levels. Specific disruption of CXCR4 oligomers reduced basal cell migration and prosurvival...
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作者：Anderson, David M.; Fey, Samuel B.; Meier, Hannah S.; Vasseur, David A.; Kremer, Colin T.
作者单位：University of British Columbia; Reed College - Portland; Yale University; University of Connecticut
摘要：The growth of populations and organisms often depends on their previous history of environmental exposure: a phenomenon referred to as phenotypic memory. The field of ecology presently lacks a mechanistic theory describing phenotypic memory and, as such, evaluating the ecological consequences of this phenomenon is a major challenge. Here, we show that internal nutrient storage connects past thermal experience to current growth in phytoplankton. We develop a mechanistic model showing that delay...
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作者：Van Loon, Senne; Rugenstein, Maria; Barnes, Elizabeth A.
作者单位：Colorado State University System; Colorado State University Fort Collins
摘要：Human emissions continue to influence Earth's climate. Effective radiative forcing quantifies the effect of such anthropogenic emissions together with natural factors on Earth's energy balance. Evaluating the exact rate of effective radiative forcing is challenging, because it can not be directly observed. Therefore, estimating the effective forcing usually relies on climate models. Here, we present an estimate of effective radiative forcing that makes optimal use of observations. We use machi...
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作者：Feng, Haizhong; Hu, Bo; Jarzynka, Michael J.; Li, Yanxin; Keezer, Susan; Johns, Terrance G.; Tang, Careen K.; Hamilton, Ronald L.; Vuori, Kristiina; Nishikawa, Ryo; Sarkaria, Jann N.; Fenton, Tim; Cheng, Tao; Furnari, Frank B.; Cavenee, Webster K.; Cheng, ShiYuan
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作者：Ball, Adam Millard -; Reginald, Monisha; Yusuf, Yasmina; Bian, Christopher
作者单位：University of California System; University of California Los Angeles; Alphabet Inc.; Google Incorporated
摘要：We use a globally consistent dataset-Google Environmental Insights Explorer-to quantify how urban form and transport infrastructure affect walking and cycling rates in 11,587 cities from 121 countries across six continents. At the city level, population density has the largest effect on walk mode share and has a positive impact on cycling too, as higher densities bring destinations within feasible walk and cycle distances. Density has the strongest effects in wealthier countries where traveler...
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作者：Bartnik, Clemens G.; Sartzetaki, Christina; Sanchez, Abel Puigseslloses; Molenkamp, Elijah; Bommer, Steven; Vuksic, Nikolina; Groen, Iris I. A.
作者单位：University of Amsterdam; University of Amsterdam
摘要：To decide how to move around the world, we must determine which locomotive actions (e.g., walking, swimming, or climbing) are afforded by the immediate visual environment. The neural basis of our ability to recognize locomotive affordances is unknown. Here, we compare human behavioral annotations, functional MRI (fMRI) measurements, and deep neural network (DNN) activations to both indoor and outdoor real-world images to demonstrate that the human visual cortex represents locomotive action aff...
