26期

最新文章

• The RRM domain-containing protein Rbp3 interacts with ribosomes and the 3' ends of mRNAs encoding photosynthesis proteins AI翻译
  作者：Hemm, Luisa; Lichtenberg, Elisabeth; Tholen, Stefan; Reimann, Viktoria; Kakazu, Kenta; Machida, Sotaro; Mahbub, Moontaha; Schilling, Oliver; Wilde, Annegret; Watanabe, Satoru; Mullineaux, Conrad W.; Hess, Wolfgang R.
  作者单位：University of Freiburg; University of Freiburg; University of Freiburg; Tokyo University of Agriculture; University of London; Queen Mary University London
  摘要：RNA recognition motif (RRM) domain proteins are crucial RNA- binding proteins across all domains of life. In cyanobacteria, single RRM domain proteins are involved in mRNA targeting to the thylakoid membrane and acclimation to certain stress conditions, but many details of their physiological functions and molecular targets have remained unknown. The model cyanobacterium Synechocystis sp. PCC 6803 has a family of three genes encoding the RRM domain-containing proteins Rbp1, Rbp2, and Rbp3. Her...
• Inhibiting Nav1.8 for pain: Lessons from patients and from neurons AI翻译
  作者：Waxman, Stephen G.; V. Vasylyev, Dmytro
  作者单位：Yale University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System
• The role of estrogen receptor β in maintaining basal cells and modulating the immune environment in the prostate AI翻译
  作者：Wu, Wan-fu; Song, Xiao-yu; Warner, Margaret; Imamov, Otabeck; Antonson, Per; Gustafsson, Jan-Ake
  作者单位：University of Houston System; University of Houston; Karolinska Institutet
  摘要：Estrogen receptor R (ERR) plays an important role in both the mouse and human prostate. The endogenous ligand for ERR is the dihydrotestosterone metabolite, 5R-androstane-3R, 17R-diol (3R-Adiol). Thus, treatment with 5-alpha reductase inhibitor (5-ARI) should produce a phenotype similar to that seen in ERR-/- mice. By comparing RNA-Seq of the ventral prostates (VP) of ERR knockout mice (ERRcrispr-/-) and wild-type (WT) mice, we confirmed that ERR modulates androgen receptor (AR) signaling indi...
• Reply to Ferraro et al.: Breed-and-feed reflects inevitable trade-offs between individual longevity and population sustainability AI翻译
  作者：Clauss, Marcus; Roller, Marco; Bertelsen, Mads F.; von Rohr, Claudia Rudolf; Mueller, Dennis W. H.; Schiffmann, Christian; Kummrow, Maya; Encke, Dag; Ferreira, Sam; Duvall, Ethan S.; Mare, Celeste; Abraham, Andrew J.
  作者单位：University of Zurich; University of Copenhagen; North West University - South Africa; Cornell University; Aarhus University; Northern Arizona University
• Calcineurin targets that mediate Cryptococcus thermotolerance AI翻译
  作者：Mitchell, Aaron P.
  作者单位：University System of Georgia; University of Georgia
• Multiomics integration prioritizes potential drug targets for multiple sclerosis AI翻译
  作者：Jiang, Yuan; Liu, Qianwen; Stridh, Pernilla; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Diaz-Gallo, Lina - Marcela; Jiang, Xia
  作者单位：Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Sichuan University; Sichuan University
  摘要：Multiple sclerosis (MS) is an immune-mediated disease with no current cure. Drug discovery and repurposing are essential to enhance treatment efficacy and safety. We utilized summary statistics for protein quantitative trait loci (pQTL) of 2,004 plasma and 1,443 brain proteins, a genome-wide association study of MS susceptibilitywith 14,802 cases and 26,703 controls, both bulk and cell-type specific transcriptome data, and external pQTL data in blood and brain. Our integrative analysis include...
• Population structure limits the use of genomic data for predicting phenotypes and managing genetic resources in forest trees AI翻译
  作者：Slavov, Gancho T.; Macaya-Sanz, David; DiFazio, Stephen P.; Howe, Glenn T.
  作者单位：Aberystwyth University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Institute of Biological, Environmental, Rural & Sciences (IBERS); UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Rothamsted Research; West Virginia University; Consejo Superior de Investigaciones Cientificas (CSIC); Oregon State University
  摘要：There is overwhelming evidence that forest trees are locally adapted to climate. Thus, genecological models based on population phenotypes have been used to measure local adaptation, infer genetic maladaptation to climate, and guide assisted migration. However, instead of phenotypes, there is increasing interest in using genomic data for gene resource management. We used whole-genome resequencing and common-garden experiments to understand the genetic architecture of adaptive traits in black c...
• Make forensic case reports required legal and scientific documents AI翻译
  作者：Higley, Leon; Carter, David O.; Elowsky, Christian; Haskell, Christine; Haskell, Neal; Obanfunwa, John; Reinhard, Karl; Roe, Amanda; Schoenly, Ken; Simmons, Tal; Wells, Jeffrey
  作者单位：University of Nebraska System; University of Nebraska Lincoln; Chaminade University Honolulu; University of Nebraska System; University of Nebraska Lincoln; California State University System; California State University Stanislaus; Virginia Commonwealth University; State University System of Florida; Florida International University; State University System of Florida; Florida International University
• Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer AI翻译
  作者：Sushentsev, Nikita; Hamm, Gregory; Manavaki, Roido; McLean, Mary A.; Birchall, Jonathan; Soloviev, Dmitry; Lewis, David Y.; Aloj, Luigi; Flint, Lucy; Zakirov, Aleksandr; Mills, Ian G.; Gnanapragasam, Vincent J.; Warren, Anne Y.; Barry, Simon T.; Goodwin, Richard J. A.; Gallagher, Ferdia A.; Barrett, Tristan
  作者单位：University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; AstraZeneca; University of Glasgow; University of Cambridge; University of Oxford; Queens University Belfast; Aarhus University; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; AstraZeneca
  摘要：Cribriform prostate cancer (crPCa) is associated with poor clinical outcomes, yet its accurate detection remains challenging due to the poor sensitivity of standard- of- care diagnostic tools. Here, we use untargeted spatial metabolomics to identify fatty acid biosynthesis as a key metabolic pathway enriched in crPCa epithelium. We also show that imaging tumor copy differentiates cribriform from noncribriform intermediate- risk prostate cancers in two prospective patient cohorts. These finding...
• Fine structural design of 3βHSD1 inhibitors for prostate cancer AI翻译
  作者：He, Dongyin; Zhang, Luyao; Yu, Leiye; Zhang, Yuhang; Chen, Jingjing; Wang, Leibo; Hu, Haoran; Liu, Hongyu; Zheng, Hong; Xia, Jixin; Chen, Jiahui; Li, Chenhui; Li, Xin; Tang, Huiru; Liu, Jia; Ren, Ruobing; Hu, Youhong; Li, Zhenfei
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; Shanghai Jiao Tong University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; The Chinese University of Hong Kong, Shenzhen; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Shandong Laboratory of Yantai Drug Discovery; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Prostate cancer is a global health challenge, particularly for patients resistant to the second-generation anti-androgen receptor pathway inhibitors. The steroidogenic enzyme 3 beta-hydroxysteroid dehydrogenase type 1 (3 beta HSD1) has emerged as a promising therapeutic target and the corresponding inhibitors, biochanin-A (BCA) and its derivatives, suppress tumor growth in preclinical models and patients. However, the poor oral bioavailability of BCA hinders its clinical application. Here, we ...