26期

最新文章

• Institutions of public judgment established by social contract AI翻译
  作者：Kessinger, Taylor A.; Plotkin, Joshua B.
  作者单位：University of Pennsylvania; University of Pennsylvania
  摘要：Indirect reciprocity is a compelling explanation for stable cooperation in a large society: Those who cooperate appropriately earn a good standing, so that others are more likely to cooperate with them. However, this mechanism requires a population to agree on who has good standing and who has bad standing. Consensus can be provided by a central institution that monitors and broadcasts reputations. But how might such an institution be maintained, and how can a population ensure that it is effe...
• Genome- scale knockout simulation and clustering analysis of drug- resistant breast cancer cells reveal drug sensitization targets AI翻译
  作者：Lim, Jina; Jung, Hae Deok; Park, Soo Young; Jeon, Moonhyeon; Kim, Da Sol; Cho, Ryeongeun; Han, Dohyun; Ryu, Han Suk; Kim, Yoosik; Kim, Hyun Uk
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University (SNU); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Anticancer chemotherapy is an essential part of cancer treatment, but the emergence of resistance remains a major hurdle. Metabolic reprogramming is a notable phenotype associated with the acquisition of drug resistance. Here, we develop a computational framework that predicts metabolic gene targets capable of reverting the metabolic state of drug-resistant cells to that of drug-sensitive parental cells, thereby sensitizing the resistant cells. The computational framework performs single-gene ...
• Immune cell profiling reveals diverse niches of immune residents of the enteric nervous system and potential neuroimmune interactions AI翻译
  作者：Wang, Haozhe; Zaini, Aidil; Cardwell, Bailey; Rowe, Matthew C.; Butler, Alana; Wong, Connie H. Y.; Poole, Daniel P.; Marsland, Benjamin; Bornstein, Joel C.; Harris, Nicola L.
  作者单位：Monash University; Monash University; Monash University; Monash Medical Centre; University of Melbourne
  摘要：Gastrointestinal (GI) neuroimmune interactions are crucial sensors and regulators of tissue homeostasis. Most enteric neurons reside within the myenteric plexus of the enteric nervous system in the muscular region, forming a structure called the muscularis externa. Despite established interactions between muscularis macrophages and neurons, the presence and function of other immune cell types remains poorly characterized. Here, we mapped the muscularis immune cell landscape, revealing that div...
• Outdated reproductive norms, the naturalistic fallacy, and misunderstandings of welfare in recent call for zoo breed- and- feed programs AI翻译
  作者：Ferraro, Kristy M.; Ferraro, Anthony L.; Monk, Julia D.; Forbes, Elizabeth S.
  作者单位：Memorial University Newfoundland
• SARS-CoV-2 nucleocapsid protein directly prevents cGAS-DNA recognition through competitive binding AI翻译
  作者：Gutmann, Theresia; Kuster, David; Hyman, Anthony A.
  作者单位：Max Planck Society
  摘要：A hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the delayed interferon response. Interferons are typically produced upon host recognition of pathogen-or damage-associated molecular patterns, such as nucleic acids. While the mechanisms by which SARS-CoV-2 evades host recognition of its RNA are well studied, how it evades immune responses to cytosolic DNA-leaked from mitochondria or nuclei during infection-remains poorly understood. Here, we demonstrate th...
• Light controls gene functions through alternative splicing in fungi AI翻译
  作者：Li, Yifan; Lu, Huanhong; Guo, Degang; Li, Xiaoyan; Qi, Fei; Zhang, Jian; Fischer, Reinhard; Shen, Qirong; Yu, Zhenzhong
  作者单位：Nanjing Agricultural University; Xiamen University; Helmholtz Association; Karlsruhe Institute of Technology
  摘要：Light controls important biological processes in fungi by regulating transcriptional gene activation. Here, we found that beyond the regulation of mRNA transcript abundance, light regulates alternative splicing (AS) in the filamentous fungi Aspergillus nidulans, Trichoderma guizhouense, and Neurospora crassa. Blue light-regulated AS was involved in ergothioneine biosynthesis and conidiation in T.guizhouense, which required the blue light receptor BLR1. Blue light activated the MAPK HOG (Sak) p...
• Supporting Information for Bardy et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro (vol 112 , E2725-E2734 , 2015 ) AI翻译
  作者：Bardy, Cedric; van den Hurk, Mark; Eames, Tameji; Marchand, Cynthia; Hernandez, Ruben, V; Kellogg, Mariko; Gorris, Mark; Galet, Ben; Palomares, Vanessa; Brown, Joshua; Bang, Anne G.; Mertens, Jeorme; Bohnke, Lena; Boyer, Leah; Simon, Suzanne; Gage, Fred H.
• Generative AI without guardrails can harm learning: Evidence from high school mathematics AI翻译
  作者：Bastani, Hamsa; Bastani, Osbert; Sungu, Alp; Ge, Haosen; Kabakci, Ozge; Mariman, Rei
  作者单位：University of Pennsylvania; University of Pennsylvania
  摘要：Generative AI is poised to revolutionize how humans work, and has already demonstrated promise in significantly improving human productivity. A key question is how generative AI affects learning-namely, how humans acquire new skills as they perform tasks. Learning is critical to long-term productivity, especially since generative AI is fallible and users must check its outputs. We study this question via a field experiment where we provide nearly a thousand high school math students with acces...
• PLAA/UFD-3 regulates P- bodies through its intrinsic disordered domain AI翻译
  作者：Das, Alakananda; Qiu, Yanping; Wolf, Trevor J.; Brissett, Ella; Cho, Jaehyoung; Park, Heenam; Chen, Eugene C.; Chou, Tsui - Fen; Sternberg, Paul W.
  作者单位：California Institute of Technology; Claremont Colleges; Claremont McKenna College; Claremont Graduate University
  摘要：Regulation of proteome homeostasis is crucial for the survival and adaptation to changing environments for all species. In eukaryotes, this process is finely tuned through regulation at the level of transcription, translation, protein modification, and protein degradation. The phospholipase A2 activating protein (PLAA) is present in all eukaryotes and believed to be a key player in ubiquitin-dependent protein sorting and degradation via its interactions with ubiquitin and/or the AAA+ ATPase, v...
• Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain AI翻译
  作者：Lancon, Kevin; Tian, Jiakang; Bach, Haleigh; Drapeau, Pierre; Poulin, Jean- Francois; Seguela, Philippe
  作者单位：McGill University; McGill University; Universite de Montreal
  摘要：Chronic pain arises from maladaptive changes in both peripheral and central nervous systems, including the anterior cingulate cortex (ACC), a key region implicated in descending pain modulation. Chronic pain increases the excitability of pyramidal neurons in the ACC. Although a reduction in inhibitory inputs onto pyramidal neurons has been observed in neuropathic conditions, the identity of the specific interneurons responsible remains unclear. We show that chronic pain selectively impairs par...