26期

最新文章

• JunB-HBZ nuclear translocation by TGF-β is a key driver in HTLV-1-mediated leukemogenesis AI翻译
  作者：Zhang, Wenyi; Shichijo, Takafumi; Chen, Xueda; Watanabe, Miho; Nosaka, Kisato; Matsuoka, Masao; Yasunaga, Jun-ichirou
  作者单位：Kumamoto University
  摘要：The HTLV-1 bZIP factor (HBZ) gene, which is the only viral gene conserved and consistently expressed in all adult T-cell leukemia-lymphoma (ATL) cases, is critical for ATL oncogenesis. Although HBZ protein is found in both the nucleus and the cytoplasm, the dynamics of HBZ protein localization and its contribution to oncogenesis have not been fully elucidated. In this study, we analyzed the subcellular expression pattern of HBZ in primary HTLV-1-infected T cells from asymptomatic carriers and ...
• Cenozoic geoclimatic changes drove the evolutionary dynamics of floristic endemism on the Qinghai-Tibet Plateau AI翻译
  作者：Cao, Guan-Long; Li, Xiao-Qian; Zhang, Jun; Peng, Huan-Wen; Li, Hong-Lei; Erst, Andrey S.; Jabbour, Florian; Ortiz, Rosa del C.; Soltis, Pamela S.; Soltis, Douglas E.; Wang, Wei
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Botany, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chongqing University of Arts & Sciences; Russian Academy of Sciences; Central Siberian Botanical Garden; Siberian Branch of the Russian Academy of Sciences; Universite PSL; Sorbonne Universite; Ecole Pratique des Hautes Etudes (EPHE); Missouri Botanical Gardens; State University System of Florida; University of Florida; State University System of Florida; University of Florida
  摘要：The Qinghai-Tibet Plateau (QTP) harbors extraordinarily high levels of biodiversity and endemism. The region is warming at a rate twice the global average, yet the evolutionary dynamics of its unique biota are poorly understood. Here, we used the endemic land plant genera of the QTP to investigate how its floristic endemism was shaped over time by Cenozoic geoclimatic changes. We first clarified that the QTP hosts 82 endemic land plant genera; we found that the origins of these endemic genera ...
• S-adenosylmethionine metabolism buffering is regulated by a decrease in glycine N-methyltransferase via the nuclear ubiquitin-proteasome system AI翻译
  作者：Kashio, Soshiro; Miura, Masayuki
  作者单位：University of Tokyo; Tohoku University; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Basic Biology (NIBB)
  摘要：Metabolic homeostasis is essential for survival; however, many studies have focused on the fluctuations of these factors. Furthermore, while metabolic homeostasis depends on the balance between the production and consumption of metabolites, there have been limited investigations into the mechanisms regulating their consumption. S-adenosylmethionine (SAM) metabolism has diverse functions, including methylation, polyamine biosynthesis, and transsulfuration, making its regulation and control cruc...
• Genetic contributions to brain criticality and its relationship with human cognitive functions AI翻译
  作者：Xin, Yumeng; Cui, Yue; Yu, Shan; Liu, Ning
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Recently, extensive evidence has demonstrated that the brain operates close to a critical state, characterized by dynamic patterns known as neuronal avalanches. The critical state, reflecting the delicate balance between neural excitation and inhibition, offers numerous advantages in information processing. However, the role of genetics in shaping brain criticality is not fully understood. Whether there is any shared genetic factor influencing the critical state and cognitive functions remains...
• Comparative performance of viral landscape phylogeography approaches AI翻译
  作者：Dellicour, Simon; Gambaro, Fabiana; Jacquot, Maude; Lequime, Sebastian; Baele, Guy; Gilbert, Marius; Pybus, Oliver G.; Suchard, Marc A.; Lemey, Philippe
  作者单位：Universite Libre de Bruxelles; KU Leuven; Universite Libre de Bruxelles; Vrije Universiteit Brussel; Ifremer; University of Groningen; University of Oxford; University of London; University of London Royal Veterinary College; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：The rapid evolution of RNA viruses implies that their evolutionary and ecological processes occur on the same time scale. Genome sequences of these pathogens therefore can contain information about the processes that govern their transmission and dispersal. Landscape phylogeographic approaches use phylogeographic reconstructions to investigate the impact of environmental factors and variables on the spatial spread of viruses. Here, we extend and improve existing approaches and develop three no...
• NBS1 facilitates preribosomal RNA biogenesis (vol 122, e2422029122, 2025) AI翻译
  作者：Luo, Man; Yu, Xiaochun
• Diploidization in a wild rice allopolyploid is both episodic and gradual AI翻译
  作者：Wang, Xin; Li, Ning; Wang, Qian; Lei, Tian-Yu; Zhou, Ju; Zhang, Fu-Min; Liao, Xue-Zhu; Qiang, Cheng-Gen; Yu, Wen-Hao; Han, Jing-Dan; Ye, Ya-Rong; Jing, Chun-Yan; Wang, Mei-Xia; Gao, Qiang; Chen, Jin-Feng; Jiao, Yuan-Nian; Wu, Zhi-Qiang; Guo, Ya-Long; Wing, Rod A.; Doyle, Jeff J.; Ge, Song; Zou, Xin-Hui
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Botany, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Guangdong Laboratory for Lingnan Modern Agriculture; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Chinese Academy of Sciences; Institute of Zoology, CAS; University of Arizona; Cornell University; Cornell University
  摘要：Polyploid organisms evolve from their initial doubled genomic condition through a number of processes collectively termed diploidization, whose tempo and mode remain poorly understood mainly due to the difficulty of discriminating de novo evolution subsequent to polyploidy from variation inherited from progenitors. Here, we generated chromosome-scale genome assemblies for the wild rice allopolyploid Oryza minuta and its two diploid progenitors, Oryza punctata and Oryza officinalis, and employe...
• An ABA-POP toggle switch orchestrates xylem differentiation and cell wall patterning AI翻译
  作者：Alberti, Valentina Elettra; Bloch, Daria; Gengel, Erik; Puli, Mallikarjuna Rao; Poraty-Gavra, Limor; Yalovsky, Shaul
  作者单位：Tel Aviv University; Tel Aviv University; Tel Aviv University; Rabin Medical Center
  摘要：The mutual antagonistic signaling of abscisic acid (ABA) and ROP GTPases highlights an intersection between stress responses and pattern formation. Previously, we have shown that signaling of ABA in the endodermis leads to protoxylem (PX) differentiation. In this study, we demonstrate that ROPs suppress PX differentiation in the roots of both Arabidopsis and tomato. Fourier transform and Shannon's entropy show that endodermal ABA signaling controls the periodicity and overall order of PX secon...
• On the mechanism of photodriven hydrogenations of N2 and other substrates by Hantzsch ester: Buffer is key to reactive H- atom donors AI翻译
  作者：Johansen, Christian M.; Benazzi, Elisabetta; Peters, Jonas C.
  作者单位：California Institute of Technology
  摘要：The Hantzsch ester (HEH2) has found considerable utility as a photoreductant in synthesis, with photodriven transfer hydrogenation reactions typically limited to activated substrates. We recently established that the addition of an organic buffer of collidinium triflate [(ColH)OTf] and collidine (Col) allows photodriven transfer hydrogenation from HEH2 to N2 forming NH3 (nitrogen reduction; N2R) in the presence of a Mo catalyst. Given the requirements for Mo-catalyzed thermally driven N2R, thi...
• Setdb1 ablation in macrophages attenuates fibrosis in heart allografts AI翻译
  作者：Ma, Zhibo; Zhou, Xi; Jia, Wenlong; Tan, Xiaosheng; Huang, Xia; Wang, Jingzeng; Sun, Lingjuan; Li, Qingwen; Zhao, Xiangli; Yuan, Naonao; Liu, Ping; Liu, Jing; Chen, Zhishui; Lan, Peixiang; Nathan, Carl F.
  作者单位：Huazhong University of Science & Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Huazhong University of Science & Technology; Huazhong University of Science & Technology
  摘要：Tissue fibrosis is commonly associated with organ malfunction and is strongly associated with the development of chronic rejection, cardiovascular diseases, and other chronic diseases. Fibrosis also contributes to immune exclusion in tumor tissues. Targeting fibrosis might be a strategy for prolonging allograft survival while suppressing cancer development. Here, single- cell transcriptomes of human and mouse heart allografts showed that macrophages accumulated in grafts with fibrosis were rep...