27期

最新文章

• Transformative community-engaged science: Strengthening relationships between science and society AI翻译
  作者：Pandya, Rajul E.; Boyd, Amanda D.; Feliu-Mojer, Monica I.; Yanovitzky, Itzhak
  作者单位：Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Washington State University; Washington State University; Rutgers University System; Rutgers University New Brunswick
  摘要：There is a critical need to strengthen science-society relationships-especially with historically marginalized communities-if we are to better and more equitably manage complicated, intertwined, global challenges at the intersection of environment, health, equity, and well-being. Community-engaged science, which focuses on shared leadership and mutual benefit in scientific partnership with communities, has the potential to transform science, communities, and even society. Despite this promise,...
• The earliest domestic pigs in Neolithic China were closely managed AI翻译
  作者：Rowley-Conwy, Peter
  作者单位：Durham University
• A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system AI翻译
  作者：Vasudevan, Harish N.; Arang, Nadia; Nunez, Maria Sacconi; Kennedy, Patrick; Payne, Emily; Mohabeer, Sarah; Chien, Julian; Wright, Aaron; Sale, Matthew J.; Krogan, Nevan J.; Forget, Antoine; Mccormick, Frank
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center
  摘要：The NF1 tumor suppressor gene is recurrently mutated in human cancers and is associated with the neurofibromatosis type 1 (NF-1) cancer predisposition syndrome. NF1 encodes neurofibromin, a Ras guanosine triphosphate (GTPase) activating protein that negatively regulates Ras signaling. NF1 mutation accordingly leads to Ras misactivation and downstream activation of RAF/MEK/ERK signaling, leading to the approval of the MEK inhibitor selumetinib for NF-1 associated peripheral nervous system (PNS)...
• Fertile androgenetic mice generated by targeted epigenetic editing of imprinting control regions AI翻译
  作者：Wei, Yanchang; Yue, Tao; Wang, Yuanyuan; Yang, Yan
  作者单位：Shanghai Jiao Tong University
  摘要：Each new mammalian life begins with the fusion of an oocyte and a sperm to produce a fertilized egg containing two sets of genomes, one from the mother and one from the father. Androgenesis, a way for producing offspring solely from male genetic material, is limited in mammals, presumably due to barriers arising from genomic imprinting, an epigenetic mechanism leading to monoallelic gene expression. Here, we report adult mammalian offspring derived from the genetic material of two sperm cells....
• Detecting environmentally dependent developmental plasticity in fossilized individuals AI翻译
  作者：Brombacher, Anieke; Searle-Barnes, Alex; Mulqueeney, James M.; Standish, Christopher D.; Milton, J. Andy; Katsamenis, Orestis L.; Watson, Richard A.; Trueman, Clive; Sinclair, Ian; Wilson, Paul A.; Foster, Gavin L.; Ezard, Thomas H. G.
  作者单位：NERC National Oceanography Centre; University of Southampton; Yale University; NERC National Oceanography Centre; Natural History Museum London; University of Southampton; University of Southampton; University of Southampton; University of Southampton
  摘要：The fossil record provides the most powerful evidence of large-scale biodiversity change on Earth, but it does so at coarse and often idiosyncratic temporal scales. One critical problem that arises concerns the evolutionary consequences of individual environmental experience. Individuals respond to their environment instantaneously, whereas the resolution of most fossil records aggregates multiple paleoenvironments over time scales beyond individual lifespans. Therefore, the presence of phenot...
• Operando Raman characterization of unique electroinduced molecular tautomerization in zero- gap electrolyzers promotes CO2 reduction AI翻译
  作者：Li, Ling; Ye, Wentao; Liu, Qiliang; Liu, Ruoxi; Lu, Xingyu; Yao, Tianbing; Wang, Linqin; Gu, Bing; Sun, Licheng; Yang, Wenxing
  作者单位：Westlake University; Westlake University; Westlake University; Baima Lake Laboratory; Westlake University; Westlake University; Westlake University; Westlake University; Westlake University
  摘要：Membrane electrode assembly (MEA) represents an advanced type of electrochemical device currently widely used in various electrocatalysis applications [e.g., electrochemical CO2 reduction reaction (CO2RR)], featuring no explicit catholyte flow and a unique solid-liquid-gas triple- phase interface. Herein, we identify a peculiar electroinduced thiol to thione tautomerization of 4- mercaptopyridine (4MPy) molecule on Cu catalyst surfaces at this triple- phase interface driven by cathodic polariz...
• Expanding the diversity of bacterial DNA partitioning: A CTP-independent ParABS system for plasmid partitioning in Streptomyces AI翻译
  作者：Sukhoverkov, Kirill, V; Balaguer-Perez, Francisco; Aicart-Ramos, Clara; Tran, Ngat T.; Maqbool, Abbas; Rejzek, Martin; Chandra, Govind; Moreno-Herrero, Fernando; Le, Tung B. K.
  作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Nacional de Biotecnologia (CNB); UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center
  摘要：The ATP- and CTP- dependent ParA- ParB- parS segrosome is a macromolecular complex that segregates chromosomes/plasmids in most bacterial species. CTP binding and hydrolysis enable ParB to slide along DNA and to bridge and condense DNA, thereby dictating the size and dynamics of the tripartite ParABS complex. Several other evolutionarily distinct systems can also segregate DNA, although the full diversity of bacterial DNA partition systems remains unknown. Here, we identify a CTP- independent ...
• Reply to Ju et al.: Mechanisms of deeper soil organic carbon loss AI翻译
  作者：Zhoua, Zhenghu; Xu, Minggang; Cai, Andong
  作者单位：Northeast Forestry University - China; Northeast Forestry University - China; Chinese Academy of Agricultural Sciences; Institute of Agricultural Resources & Regional Planning, CAAS; Chinese Academy of Agricultural Sciences; Institute of Environment & Sustainable Development in Agriculture, CAAS
• 15-PGDH inhibition preserves blood-brain barrier integrity and cognition AI翻译
  作者：van Egmond, Daisy M.; Lygeroudi, Anita; Kooij, Gijs
  作者单位：Vrije Universiteit Amsterdam
• Tendencies toward triadic closure: Field experimental evidence AI翻译
  作者：Mosleh, Mohsen; Eckles, Dean; Rand, David G.
  作者单位：University of Oxford; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：Empirical social networks are characterized by a high degree of triadic closure (i.e., transitivity, clustering): network neighbors of the same individual are also likely to be directly connected. It is unknown to what degree this results from dispositions to form such ties (i.e., to close open triangles) per se versus other processes such as homophily and more opportunities for exposure. These mechanisms are difficult to disentangle in many settings. On social media, however, they can be deco...