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作者：Miao, Runze; Howard, Alan D.; Dietrich, William E.
作者单位：University of California System; University of California Berkeley; University of Virginia
摘要：The discovery of paleo-meanders on Mars and debates about the occurrence of meandering on prevegetation early Earth have stimulated field studies of channel morphology and deposit stratigraphy in arid environments. They show that mud can provide the cohesive strength to retard outer bank erosion, enabling inner bank lateral accretion (including mud deposition) to keep pace and thus sustain meandering. The process by which mud is deposited in the lateral accretion deposits, however, is poorly k...
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作者：Ruby, Carolyn; Novick, Richard P.
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作者：Kao, Kevin S.; Pihlstrom, Nicole L.; Niejadlik, Emily G.; Cantaert, Tineke; Ahmed, Rafi; Ravetch, Jeffrey, V; Bournazos, Stylianos
作者单位：Rockefeller University; Pasteur Network; Institut Pasteur Cambodia; Emory University; Emory University; Emory University
摘要：A critical component of the function of IgG antibodies is their capacity to engage specialized cellular receptors, Fc gamma receptors (Fc gamma Rs), expressed on effector leukocytes. Highlighting the importance of Fc gamma R-mediated signaling in the regulation of the fate, activation, and differentiation status of leukocytes, Fc gamma Rs are ubiquitously expressed by nearly all leukocyte populations. Here, we report that while at steady state, T cells are negative for all classes of Fc gamma ...
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作者：Hu, Longhua; Perez, Amilcar J.; Nesterova, Tanya; Lyu, Zhixin; Yahashiri, Atsushi; Weiss, David S.; Xiao, Jie; Liu, Jian
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; University of Iowa; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
摘要：FtsZ, the tubulin-like GTPase, is the central organizer of the bacterial divisome, a macromolecular complex that synthesizes new septal cell wall (made of septal peptidoglycan, sPG) to allow cell wall constriction and cytokinesis. In Escherichia coli, it was shown that 1) FtsZ recruits all essential divisome proteins to the septum, including the core sPG synthase complex, FtsWIQLB, and its activator, FtsN; 2) FtsWIQLB must complex with FtsN to be activated to synthesize sPG under the wildtype ...
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作者：Jeon, Juwan; Li, Qi-Jian; Lee, Jeong-Hyun
作者单位：Korea University; Korea University; Institute for Basic Science - Korea (IBS); Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chungnam National University
摘要：The fossil record often creates an illusion of sudden evolutionary bursts, which may reflect preservation biases rather than actual biological events. The Great Ordovician Biodiversification Event (GOBE) appears to mark the abrupt rise of diverse reef-building metazoans during the late Darriwilian (similar to 460 Ma), seemingly contradicting gradual evolutionary models. Here, we demonstrate this apparent burst is largely an artifact of a global sea-level fall (similar to 475 to 460 Ma) that pr...
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作者：Ju, Xiaotang; Zhang, Chong; Tian, Xue
作者单位：Hainan University
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作者：Chauhan, Komal; Datta, Dipanwita; Kapoor, Yogita; Passricha, Nishat; Dutt, Ravi; Arora, Naresh; Das, Mrinmoy; Rao, Kavya; Singh, Lakshyaveer; Gautam, Arunima; Sharma, Raman Deep; Sarkar, Binayak; Yadav, Mohit; Malakar, Basanti; Kalam, Haroon; Saini, Prince; Mehra, Lalita; Das, Prasenjit; Ahuja, Vineet; Singhal, Amit; Nandicoori, Vinay; Kumar, Dhiraj
作者单位：Department of Biotechnology (DBT) India; International Center for Genetic Engineering & Biotechnology (ICGEB); International Center for Genetic Engineering & Biotechnology (ICGEB), New Delhi; Council of Scientific & Industrial Research (CSIR) - India; CSIR - Centre for Cellular & Molecular Biology (CCMB); Academy of Scientific & Innovative Research (AcSIR); Department of Biotechnology (DBT) India; National Institute of Immunology (NII); Indian Institute of Science Education & Research (IISER) - Mohali; All India Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of Medical Sciences (AIIMS) New Delhi; Agency for Science Technology & Research (A*STAR); A*STAR Infectious Diseases Labs (A*STAR IDL); Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN)
摘要：Transcriptional adaptation drives the host responses to Mycobacterium tuberculosis (Mtb) the mechanism for which remains unknown. Here, we report a mechanism whereby a secreted Mtb protein interferes with the biogenesis of key spliceosomal components. A ing with the host RNA splicing factors (SFs). Through custom- designed in- cell assays, between Mtb phagosomes and U5 snRNA and SNRPF, key components of the snRNPs. Genetic deletion of Rv1435c/hsr1 reverses the specific exon- skipping events ca...
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作者：Akiyama, Sota; Ople, Rohini S.; Kremsmair, Alexander; Ramos-Gonzalez, Nokomis; Nedungadan, Thomas; Kennedy, Brandon J.; Appourchaux, Kevin; Eans, Shainnel O.; Tsai, Bowen A.; Kraml, Christina; Huang, Xi-Ping; McLaughlin, Jay P.; Majumdar, Susruta; Sarpong, Richmond
作者单位：University of California System; University of California Berkeley; Washington University (WUSTL); Washington University (WUSTL); University of Health Sciences & Pharmacy in St. Louis; Princeton University; State University System of Florida; University of Florida; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：Morphine is a mu- opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and addiction. Here, we show that a single heavy atom replacement in the morphine core structure (O to CH2 exchange in the E-ring) prepared through a 15-step total synthesis displays a different pharmacological profile. The total synthesis features an intramolecular inverse electron-demand Diels-Alder cycloaddition and a stereoselective Giese radical ...
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作者：Tian, Fucheng; Sato, Katsuhiko; Zheng, Yong; Lu, Feixue; Gong, Jian Ping
作者单位：Hokkaido University; University of Toyama; Xi'an Jiaotong University; Hokkaido University
摘要：Soft-hard composite strategy is a highly general yet powerful approach to overcome the inherent trade-off between strength and toughness in material design. However, the underlying toughening mechanisms, veiled by nonlinearities and complex network interactions, remains unclear. Here, we employ a three-dimensional soft-hard composite (SH-com) framework by arranging randomly distributed linear-elastic soft and hard elements to explore the toughening mechanisms of soft-hard composites, while shi...
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作者：Welker, Christopher; Wheatley, Thalia; Meyer, Meghan
作者单位：Dartmouth College; The Santa Fe Institute; Columbia University
