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作者：Langlois-Lemay, Laurence; D'Amours, Damien
作者单位：University of Ottawa
摘要：The ability of cells to overcome cell cycle arrest and adapt to the presence of unrepairable DNA damage is under the control of Polo-like kinases (PLKs) in eukaryotes. How DNA damage checkpoints are silenced or bypassed during the adaptation response is unknown, but the process requires enrichment of the Cdc5 PLK to microtubule organizing centers (MTOCs), such as the yeast centrosomes or spindle pole bodies (SPBs). Here, we found that SPBs play an active role as supramolecular organizing cente...
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作者：Aksoy, Cevat Giray; Barrero, Jose Maria; Bloom, Nicholas; Davis, Steven J.; Dolls, Mathias; Zarate, Pablo
作者单位：European Bank of Reconstructon & Development; University of London; King's College London; University of London; King's College London; Instituto Tecnologico Autonomo de Mexico; Stanford University; Stanford University; Leibniz Association; Ifo Institut; Princeton University
摘要：Work from home (WFH) surged worldwide during the COVID-19 pandemic, then partially receded as the pandemic subsided. Using our Global Survey of Working Arrangements covering dozens of countries, we find that average WFH rates among college-educated employees stabilized after 2022. The average number of WFH days per week is steady at roughly 1 d per week globally from 2023 through early 2025. Cross-country variation persists: WFH is about twice as common in advanced English-speaking economies a...
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作者：Dargis, Rokas; Pajak, Joshua; Ariyawansa, Pavan; Morais, Marc C.; Jardine, PaulJ.; Arya, Gaurav
作者单位：Duke University; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Indiana University System; Indiana University Bloomington; University of Minnesota System; University of Minnesota Twin Cities
摘要：Certain viruses such as tailed bacteriophages and herpes simplex virus package double-stranded DNA into empty procapsids via powerful, ring-shaped molecular motors. High-resolution structures and force measurements on the DNA packaging motor of bacteriophage X29 revealed that its five ATPase subunits coordinate ATP hydrolysis with each other to maintain the proper cyclic sequence of DNA translocation steps about the ring. Here, we explore how the X29 motor regulates translocation by timing key...
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作者：Gulati, Vaishali; Bhowmick, Shaileyee; Byrnes, Tim; Radhakrishnan, Chandrashekar; Dorai, Kavita
作者单位：Indian Institute of Science Education & Research (IISER) - Mohali; New York University; NYU Shanghai; East China Normal University; New York University; New York University; NYU Shanghai
摘要：Quantum discord is a measure of nonclassical correlations in quantum systems. While the bipartite version of quantum discord is experimentally well-studied, the multipartite version has never been convincingly measured. In this study, we experimentally investigate tripartite quantum discord using an NMR quantum information processor. Building on a theoretical framework for conditional projective measurements and quantum conditional mutual information, we quantify the tripartite quantum discord...
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作者：Jendrichovskya, Peter; Khosravib, Sahar; Rupasinghed, Anuththara; Maximova, Katherine; Guoa, Pinyue; Babadib, Behtash; Kanold, Patrick O.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; Princeton University; Johns Hopkins University; Johns Hopkins University
摘要：Analyzing the functional connectivity of the brain is an enormous challenge, as deciphering functional connectivity requires knowledge of functional responses and connections. One promising strategy is analyzing the spatial pattern of activity correlations across cell populations. In the primary auditory cortex (A1), cells respond to different sound features. On the large scale, there exists a tonotopic map, which is fractured at the small scale, raising the question of whether functional conn...
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作者：Lee, Jake H.; Kiper, Michael; Thompson, David R.; Brodrick, Philip G.
作者单位：National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology
摘要：Current and upcoming generations of visible-shortwave infrared (VSWIR) imaging spectrometers promise unprecedented capacity to quantify Earth system processes across the globe. However, reliable cloud screening remains a fundamental challenge for these instruments, where traditional spatial and temporal approaches are limited by cloud variability and limited temporal coverage. The Spectroscopic Transformer (SpecTf) addresses these challenges with a spectroscopy-specific deep-learning architect...
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作者：Leota, Josh; Czeisler, Mark E.; Le, Flora; Presby, David M.; Capodilupo, Emily R.; Scott, Hannah; Wiley, Joshua F.; Drummond, Sean P. A.; Rajaratnam, Shantha M. W.; Facer-Childs, Elise R.
作者单位：Monash University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Swiss Institute of Bioinformatics; University of Lausanne; Flinders University South Australia
摘要：Sleep and physical activity (PA) are pillars of health. However, the temporal dynamics between these two behaviors remain poorly understood. This research aims to examine the independent and interactive between-and within-person associations of sleep duration and sleep onset timing on next-day PA duration in two large, longitudinal samples of adults under free-living conditions. In the primary study, participants (N = 19,963; 5,995,080 person-nights) wore a validated biometric device (WHOOP) f...
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作者：Sahakyan, Harutyun; Babajanyan, Sanasar G.; Wolf, Yuri I.; Koonin, Eugene V.
作者单位：National Institutes of Health (NIH) - USA; Division of Intramural Research (DIR); NIH National Library of Medicine (NLM)
摘要：The origin and evolution of protein folds are among the most challenging, long-standing problems in biology. We developed Protein Fold Evolution Simulator (PFES), a computational approach that simulates evolution of globular folds from random amino acid sequences with atomistic details. PFES introduces random mutations in a population of protein sequences, evaluates the effect of mutations on protein structure, and selects a new set of proteins for further evolution. Iteration of this process ...
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作者：Asabuki, Toshitake; Gillon, Colleen J.; Clopath, Claudia
作者单位：Imperial College London; RIKEN
摘要：The predictive coding hypothesis proposes that top-down predictions are compared with incoming bottom-up sensory information, with prediction errors signaling the discrepancies between these inputs. While this hypothesis explains the presence of prediction errors, recent experimental studies suggest that prediction error signals can emerge within a local circuit, that is, from bottom-up sensory input alone. In this paper, we test whether local circuits alone can generate predictive signals by ...
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作者：Kannan, Sudharsan; Kasberg, William; Ernandez, Liliana R.; Audhya, Anjon; Robertson, Gail A.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Mechanisms underlying heterotypic subunit assembly of ion channels and other oligomeric complexes are poorly understood. In the human heart, heteromeric assembly of two isoforms encoded by the human ether-& agrave;- go-go related gene (hERG) is essential for the normal function of cardiac IKr in ventricular repolarization, with loss of hERG1b contributing to arrhythmias associated with long QT-syndrome (LQTS). While hERG1a homomers traffic efficiently to the plasma membrane, hERG1b homomers ar...
