27期

最新文章

• Molecular basis for substrate recognition and transport of mammalian taurine transporters AI翻译
  作者：Wang, Mingxing; He, Jin; Cai, Qianwen; Zhang, Shen-ao; She, Ji
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：The taurine transporter (TAUT) mediates cellular taurine uptake, playing a critical role in human health and longevity. In this study, we present cryogenic electron microscopy structures of both mouse and human TAUT in various conformational states. The taurine-bound, occluded forms of mouse and human TAUT reveal the substrate binding pocket and the ion binding sites. The amino group of taurine interacts with Glu406 at the binding site, constituting a key structural feature determining substra...
• Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition AI翻译
  作者：Daly, James L.; Chen, Kai - en; Butkovic, Rebeka; Guo, Qian; Healy, Michael D.; Pennink, Eva; Gamble-Strutt, Georgia; Higham, Zara; Moody, Edmund R. R.; Lewis, Philip A.; Heesom, Kate J.; Williams, Tom A.; McMillan, Kirsty J.; Collins, Brett M.; Cullen, Peter J.; Hurley, James
  作者单位：University of Bristol; University of West England; Guy's & St Thomas' NHS Foundation Trust; University of London; King's College London; University of Queensland; University of Bristol; University of Bristol; University of Liverpool
  摘要：The endosomal-lysosomal network is a hub of organelles that orchestrate the dynamic sorting of hundreds of integral membrane proteins to maintain cellular homeostasis. VPS29 is a central conductor of this network through its assembly into Retromer, Retriever, and Commander endosomal sorting complexes, and its role in regulating RAB GTPase activity. Two VPS29 isoforms have been described, VPS29A and VPS29B, that differ solely in their amino-terminal sequences. Here, we identify a third VPS29 is...
• Onset of cavitation and vapor bubble development over hydrophilic and hydrophobic surfaces AI翻译
  作者：Lin, Chensen; Maxey, Martin R.; Li, Zhen; Zhang, Kaixuan; Karniadakis, George Em
  作者单位：Fudan University; Brown University; Clemson University; Nankai University
  摘要：Cavitation, the formation of vapor bubbles as the liquid pressure is reduced below the saturated vapor pressure, often requires a substantial negative relative pressure in a pure liquid. Classical nucleation theory (CNT) provides an estimate for the rate of cavitation but there is often a disconnect between the predictions at the molecular scale compared to observations at the macroscale. We report on mesoscale simulations of cavitation based on many-body dissipative particle dynamics (mDPD), ...
• Prehistoric archives reveal evidence of predator loss and release in Caribbean reef fish communities AI翻译
  作者：O'Dea, Aaron; Dillon, Erin M.; Brandl, Simon J.; Cramer, Katie L.; Cybulski, Jonathan D.; de Gracia, Brigida; Garcia-Mendez, Kimberly; Griswold, Katherine; Lin, Chien-Hsiang; Leray, Matthieu; Lueders-Dumont, Jessica A.; Sellers, Andrew J.; Wake, Thomas A.
  作者单位：Smithsonian Institution; Smithsonian Tropical Research Institute; Secretaria Nacional de Ciencia, Tecnologia e Innovacin (SENACYT); University of Texas System; University of Texas Austin; Arizona State University; Arizona State University-Tempe; University of Rhode Island; Academia Sinica - Taiwan; Boston College; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Understanding how humans have altered coral reef food webs remains challenging due to the absence of prehistoric baselines. Here, we use fish remains preserved in fossil and archaeological deposits from Panam & aacute; and the Dominican Republic to explore how Caribbean reef fish mortality patterns have changed over millennia. By quantifying accumulation rates of shark dermal denticles (scales) and bony fish otoliths (ear stones) in reef sediments, we assess relative fish abundance, while otol...
• A molecular tango between chromatin and metabolites orchestrates a feedback switch for alcohol consumption AI翻译
  作者：Schmidt, Heidi M.; Tarling, Elizabeth J.; Vallim, Thomas Q. de Aguiar
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
• Rising surface salinity and declining sea ice: A new Southern Ocean state revealed satellites AI翻译
  作者：Silvano, Alessandro; Narayanan, Aditya; Catany, Rafael; Olmedo, Estrella; Gonzalez-Gambau, Veronica; Turiel, Antonio; Sabia, Roberto; Mazloff, Matthew R.; Spira, Theo; Haumann, F. Alexander; Garabato, Alberto C. Naveira
  作者单位：NERC National Oceanography Centre; University of Southampton; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Mediterraneo de Investigaciones Marinas y Ambientales (CMIMA); CSIC - Instituto de Ciencias del Mar (ICM); European Space Agency; European Space Research Institute; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Gothenburg; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Munich
  摘要：For decades, the surface of the polar Southern Ocean (south of 50 degrees S) has been freshening-an expected response to a warming climate. This freshening enhanced upper-ocean stratification, reducing the upward transport of subsurface heat and possibly contributing to sea ice expansion. It also limited the formation of open-ocean polynyas. Using satellite observations, we reveal a marked increase in surface salinity across the circumpolar Southern Ocean since 2015. This shift has weakened up...
• Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice AI翻译
  作者：Vittani, Marta; Herlo, Rasmus; Wang, Xiaowen; Christensen, Michala Daniela Bach; Vo, Camilla Trang; Mishima, Tsuneko; Kusk, Peter; Konno, Ayumu; Hirai, Hirokazu; Tsuboi, Takashi; Kitaguchi, Tetsuya; Kjaerby, Celia; Asiminas, Antonis; Yokoyama, Tatsushi; Sakamoto, Masayuki; Nedergaard, Maiken; Hirase, Hajime
  作者单位：University of Copenhagen; Columbia University; University of Southern Denmark; Gunma University; Gunma University; University of Tokyo; Kyoto University; University of Rochester
  摘要：Local neural activation drives regional increase of cerebral blood flow (CBF), in a phenomenon known as functional hyperemia. Astrocytes, which enwrap cerebral blood vessels and respond to neuronal activity through their G protein-coupled receptors (GPCRs), play a vital role in brain energy metabolism. Although astrocytic calcium (Ca2+) signaling has been widely studied in relation to neurovascular coupling, the role of cyclic adenosine monophosphate (cAMP), another key second messenger of GPC...
• Sulfur-mediated transformation from osmium nanocrystals to single atoms for efficient alkaline hydrogen evolution reaction AI翻译
  作者：Xue, Wendan; Zhou, Qixing; Wang, Pengfei; Zuo, Sijin; Li, Fengxiang; Jiang, Jiwei; Mo, Fan; Yin, Chuan; Liu, Gaolei; Ban, Zhan; Wei, Yuanyuan; An, Wen; Huang, Xiulin; Wang, Hui; Zhan, Sihui
  作者单位：Nankai University; China Pharmaceutical University
  摘要：Osmium (Os)- based catalysts, recognized for their unique chemical and electronic properties along with cost- effectiveness, hold great potential for the hydrogen evolution reaction (HER). However, their practical application has long been limited because pure Os exhibits excessively strong adsorption of intermediates and suffers from stability issues. Herein, we report the development of a highly stable catalyst achieved by implanting the sulfur (S) atom into the matrix, facilitating the tran...
• Jurassic constraints on the chaotic Mars-Earth eccentricity cycle linked to the volcanically induced Jenkyns event AI翻译
  作者：Fang, Yanan; Olsen, Paul E.; Sha, Jingeng; Whiteside, Jessica H.; Guan, Chengguo; Ikeda, Masayuki; Li, Sha; Zheng, Daran; Zhang, Haichun; Wang, Bo
  作者单位：Chinese Academy of Sciences; Columbia University; Columbia University; California State University System; San Diego State University; University of Tokyo
  摘要：Solar system gravitational interactions are embedded in Earth's record of climate, providing a way to bypass the 60 Myr limit imposed by chaos. Presently with a 2.4 Myr period, the Mars-Earth beat cycle of orbital perihelion frequencies is particularly sensitive to chaotic diffusion, potentially varying by more than a million years. Early Mesozoic (252 to 145 Ma) strata provide some constraints on this cycle, with evidence of a swing through most of the solution space from 1.8 Myr at 210 Ma to...
• Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast (vol 122, e2422126122, 2025) AI翻译
  作者：Hoshikawa, Yojiro; Shirota, Natsuho; Tsugawa, Hiroshi; Kimura, Satoshi; Matsuyama, Akihisa; Yashiroda, Yoko; Kakeya, Hideaki; Arita, Makoto; Iizumi, Reiko; Yoshida, Minoru; Nishimura, Shinichi
  作者单位：University of Tokyo; Hiroshima University; Hiroshima University; RIKEN; RIKEN; Yokohama City University; Tokyo University of Agriculture & Technology; University of Tokyo; RIKEN; Kyoto University; Keio University; Keio University; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Tokyo; University of Tokyo; RIKEN