27期

最新文章

• Structural state governs the mechanism of shear- band propagation in metallic glasses AI翻译
  作者：Yu, Jinhua; Zhang, Zhen; Sha, Zhendong; Ding, Jun; Greer, A. Lindsay; Ma, Evan
  作者单位：Xi'an Jiaotong University; Chengdu University of Technology; Xi'an Jiaotong University; University of Cambridge; Tohoku University
  摘要：Shear bands (SBs) play a critical role in determining the mechanical behavior of metallic glasses (MGs). However, the rapid dynamics and highly localized nature of SB propagation present significant challenges for direct observation of their atomistic mechanisms using experimental techniques. In this study, we employ hybrid molecular dynamics/Monte Carlo simulations to investigate the atomic-scale mechanisms of SB propagation in Mg65Cu25Y10 MGs, prepared using cooling rates as slow as 10(4) K ...
• UFMylation: A supervisor of the HIF1α pathway and a potential therapeutic target for anti- PD-1 combination therapy in hypoxic tumors AI翻译
  作者：Zou, Yongkang; Wang, Zhaoxiang; Jiang, Qiang; Kong, Xia; Ma, Xiaohe; Liang, Zhengyan; Wang, Zhiguo; Chen, Beiying; Yuan, Jiao; Wen, Jiayue; Ye, Sheng; Yan, Yubin; Li, Binbin; Xiong, Xing-dong; Liu, Xin-guang; He, Zhiwei; Cai, Yafei; Zhou, Junzhi
  作者单位：Shenzhen Bay Laboratory; Guangdong Medical University; Nanjing Agricultural University; Shandong Academy of Agricultural Sciences; Hangzhou Normal University; Guangzhou Medical University; Guangzhou Laboratory; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS
  摘要：Activation of hypoxia signaling has been identified as an innate resistance signature against anti- PD- 1 therapy, suggesting its potential as a target for combination treatments. Here, we demonstrate that UFMylation modification of HIF1 alpha stabilizes the protein by antagonizing its ubiquitination and proteasomal degradation under hypoxic conditions. Mechanistically, depletion of UFL1 or defective UFMylation increases HIF1 alpha binding to p53, promoting its degradation. Depletion of UFL1 o...
• Advanced synchrotron method reveals early molecular decomposition steps in a high- energy material AI翻译
  作者：Huotari, Simo
  作者单位：University of Helsinki
• The transcription factor Bcl11a is essential for B-1a cell maintenance during aging AI翻译
  作者：Xu, Shasha; Huang, Liangfeng; Liu, Xingjie; Zhang, Linlin; Wang, Jing; Hu, Yifeng; Yang, Yi; Shi, Xiaojie; Liu, Chaohong; Wang, Rong; Miao, Zhichao; Yu, Yong
  作者单位：Tongji University; Tongji University; Tongji University; Tongji University; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Youjiang Medical University for Nationalities; Guangzhou Medical University; Guangzhou Laboratory
  摘要：B- 1a cells, a self- renewing B cell subset essential for innate immunity, produce natural IgM antibodies that defend against pathogens, yet mechanisms sustaining their maintenance during aging remain unclear. We report that aging B- 1a cells exhibit hallmarks of decline, including DNA damage, apoptosis, and reduced proliferation, with striking sex- specific disparities: aged females retain higher B- 1a cell numbers than males, correlating with enhanced glycolysis and chromatin accessibility. ...
• Singularity formation in 3D Euler equations with smooth initial data and boundary AI翻译
  作者：Chen, Jiajie; Hou, Thomas Y.
  作者单位：New York University; California Institute of Technology
  摘要：A long-standing fundamental open problem in mathematical fluid dynamics and nonlinear partial differential equations is to determine whether solutions of the 3D incompressible Euler equations can develop a finite-time singularity from smooth, finite-energy initial data. Leonhard Euler introduced these equations in 1757 [L. Euler, Memoires de lA'cademie des Sci. de Berlin 11, 274-315 (1757).], and they are closely linked to the Navier-Stokes equations and turbulence. While the general singulari...
• Onset of extensive human fire use 50,000 y ago AI翻译
  作者：Jiang, Shoushu; Zhao, Debo; Kaboth-Bahr, Stefanie; Beaufort, Luc; Tu, Hua; Lu, Zhengyao; Cheng, Zhongjing; Zhang, Shanjia; Zhong, Yi; Hao, Xiudong; Pei, Wenqiang; Cui, Guangqiang; Yang, Yifei; Lin, Anni; Huang, Jie; Wan, Shiming
  作者单位：Chinese Academy of Sciences; Institute of Oceanology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Free University of Berlin; Aix-Marseille Universite; Institut de Recherche pour le Developpement (IRD); INRAE; Centre National de la Recherche Scientifique (CNRS); Shantou University; Lund University; Tongji University; Lanzhou University; Southern University of Science & Technology; Nanning Normal University; China West Normal University; Chinese Academy of Sciences; Institute of Oceanology, CAS
  摘要：Fire is a pivotal aspect of human involvement in the carbon cycle. However, the precise timing of the large-scale human fire use remains uncertain. Here, we report a pyrogenic carbon record of East Asian fire history over the past 300,000 y from the East China Sea. This record suggests a rapid increase in fire activity since approximately 50,000 y ago, indicating a decoupling from the monsoon climate, and this pattern is consistent with fire histories in Europe, Southeast Asia, and Papua New G...
• Disentangling temperature and Reynolds number effects in quantum turbulence AI翻译
  作者：Polanco, Juan Ignacio; Roche, Philippe-E.; Danaila, Luminita; Leveque, Emmanuel
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Ecole Centrale de Lyon; Institut National des Sciences Appliquees de Lyon - INSA Lyon; Universite Claude Bernard Lyon 1; Universite Jean Monnet; Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Universite de Rouen Normandie
  摘要：The interplay between viscous and frictional dissipation is key to understanding quantum turbulence dynamics in superfluid 4He. Based on a coarse-grained two-fluid description, an original scale-by-scale energy budget that identifies each scale's contribution to energy dissipation is derived. Using the Hall-Vinen-Bekharevich-Khalatnikov (HVBK) model to further characterize mutual friction, direct numerical simulations at temperatures 1.44 K less than or similar to T less than or similar to 2.1...
• Building confidence in models for complex barrier systems for radionuclides AI翻译
  作者：Sarsenbayev, Dauren; Tournassat, Christophe; Steefel, Carl I.; Wainwright, Haruko M.
  作者单位：Massachusetts Institute of Technology (MIT); United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite de Orleans; Bureau de Recherches Geologiques et Minieres (BRGM); Massachusetts Institute of Technology (MIT)
  摘要：The modeling and simulation of the Cement-clay Interaction-Diffusion field (CI-D) experiment at the Mont Terri site in Switzerland presented here demonstrates that it is possible to capture the multiscale physical and chemical features of natural and engineered barrier systems for radionuclides. The simulations are successfully carried out with the newly developed CrunchODiTi high-performance computing software that accounts for multiple continua, including a continuum representing the electri...
• The highly conserved C-terminal end segment of troponin T binds tropomyosin and actin to function in modulating contractile kinetics AI翻译
  作者：Cao, Tianxin; Feng, Han-Zhong; Jayasundar, Jayant James; Jin, J. -P.
  作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
  摘要：The troponin (Tn) complex plays a central role in regulating striated muscle contraction and relaxation. Troponin T (TnT) and troponin I (TnI) are two of the three subunits of Tn, which have evolved from a TnI-like ancestor gene. Proteolytic removal of the evolutionarily added N-terminal variable region of cardiac TnT, as occurs in acute ventricular contractility-afterload mismatch, brings back a TnI-like molecular conformation and function to reduce ventricular systolic velocity, elongates ej...
• The importance of scientists' intellectual humility for communicating effectively across ideological and identity- based divides AI翻译
  作者：Rios, Kimberly; Roth, Zachary C.; Coleman III, Thomas J.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Maine System; University of Maine Augusta; Coventry University
  摘要：Growing identity-based and partisan gaps in confidence in scientists and scientific institutions call for novel approaches to science communication. In this perspectives piece, we focus on the need for greater intellectual humility (i.e., willingness to revise one's views and admit that one might be wrong) among social scientists, who are met with particularly high levels of skepticism from the public. We begin with an overview of research demonstrating that when scientists' identities or ideo...