27期

最新文章

• Spin-informed universal graph neural networks for simulating magnetic ordering AI翻译
  作者：Xu, Wenbin; Sanspeur, Rohan Yuri; Kolluru, Adeesh; Deng, Bowen; Harrington, Peter; Farrell, Steven; Reuter, Karsten; Kitchin, John R.
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Carnegie Mellon University; Max Planck Society; Fritz Haber Institute of the Max Planck Society
  摘要：The screening and discovery of magnetic materials are hindered by the computational cost of first-principles density-functional theory (DFT) calculations required to find the ground state magnetic ordering. Although universal machine-learning interatomic potentials (uMLIPs), also known as atomistic foundation models, offer high-fidelity models of many atomistic systems with significant speedup, they currently lack the inputs required for predicting magnetic ordering. In this work, we present a...
• The cultural construction of executive function AI翻译
  作者：Kroupin, Ivan; Davis, Helen Elizabeth; Burdett, Emily; Cuata, Agustina Bani; Hartley, Vahumburuka; Henrich, Joseph
  作者单位：University of London; London School Economics & Political Science; Harvard University; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; University of Nottingham
  摘要：In cognitive science, the term executive function (EF) refers to universal features of ally specific cognitive capacities. After all, typical EF measures require forms of decontextualized/arbitrary processing which decades of cross- cultural work indicate develop primarily in schooled worlds-industrialized societies with universal schooling. Here, we report comparisons of performance on typical EF tasks by children inside, and wholly outside schooled worlds. Namely, children ages 5 to 18 from ...
• Divergent oxygen trends in ice-covered lakes driven by ice-cover decline and ecological memory AI翻译
  作者：Jansen, Joachim; Weyhenmeyer, Gesa A.; Harkonen, Laura H.; Paterson, Andrew M.; del Giorgio, Paul A.; Prairie, Yves T.
  作者单位：University of Helsinki; University of Quebec; University of Quebec Montreal; Uppsala University; Finnish Environment Institute
  摘要：Dissolved oxygen (DO) is an essential resource in ice-covered lakes, regulating water quality and biodiversity, including the survival of economically important fish species. Most of the world's lakes seasonally freeze, often resulting in oxygen depletion as ice cover inhibits water column ventilation and snow cover limits photosynthesis while respiration continues. Widespread shortening of ice-cover duration in a warmer world might improve winter oxygenation, but this hypothesis remains untes...
• Macroevolutionary changes in natural selection on codon usage reflect evolution of the tRNA pool across a budding yeast subphylum AI翻译
  作者：Cope, Alexander L.; Shah, Premal
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Vanderbilt University
  摘要：Across taxonomical domains, synonymous codons of an amino acid are found to be used at unequal frequencies within genomes. This codon usage bias (CUB) is highly variable across species. Genome-wide CUB reflects a balance between adaptive and nonadaptive microevolutionary processes within a species. Variation in microevolutionary processes results in across-species variation in CUB. As CUB is tightly linked to important molecular and biophysical processes, it is critical to understand how chang...
• PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis AI翻译
  作者：Wu, Jin; Gao, Mingming; Wu, Xiaoqin; Liu, Yang; Zhang, Taiping; Liang, Yan; Yang, Haixia; Ma, Chengxin; Ye, Youpi; Chang, Chunmei; Li, Peng; Chen, Feng-Jung; Yang, Hongyuan
  作者单位：Fudan University; University of Texas System; University of Texas Health Science Center Houston; Hebei Medical University; Zhengzhou University; University of New South Wales Sydney
  摘要：Lipid droplets (LDs) are evolutionarily conserved organelles that play important roles in metabolism. Each LD is enclosed by a monolayer of phospholipids, distinct from bilayer membranes. The composition of LD surface phospholipids and their impact on LD growth and function remain to be defined. Phosphoinositides mark cellular organelles and regulate organellar function. Here, we demonstrate that PI(4) P decorates a subset of LDs to recruit and activate CIDE proteins. Enhanced expression of OR...
• Gelated microvesicle-mediated delivery of mesenchymal stem cell mitochondria for the treatment of myocardial infarction AI翻译
  作者：Chu, Qi; He, Dong; Xie, Wenqi; Li, Shichun; Dong, Zixuan; Fu, Xiaoling
  作者单位：South China University of Technology; South China University of Technology; South China University of Technology; South China University of Technology
  摘要：Mitochondrial dysfunction is closely linked to cardiomyocyte injury following myocardial infarction (MI). While mitochondrial transplantation is a promising therapeutic strategy, challenges remain in maintaining mitochondrial structural integrity, enhancing delivery efficiency, and increasing the mitochondrial supply. Herein, we developed a gelated microvesicle-based mitochondria delivery system (Mito@Microgels) for transplanting mesenchymal stem cell mitochondria, addressing the aforementione...
• Action-mode subnetworks for decision-making, action control, and feedback AI翻译
  作者：D'Andrea, Carolina Badke; Laumann, Timothy O.; Newbold, Dillan J.; Lynch, Charles J.; Hadji, Mohammad; Nelson, Steven M.; Nielsen, Ashley N.; Chauvin, Roselyne J.; Krimmel, Samuel R.; Snyder, Abraham Z.; Marek, Scott; Greene, Deanna J.; Raichle, Marcus E.; Dosenbach, Nico U. F.; Gordon, Evan M.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); University of California System; University of California San Diego; New York University; Cornell University; Weill Cornell Medicine; University of Minnesota System; University of Minnesota Twin Cities; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：The action-mode network (AMN) is a canonical functional brain network first identified using resting-state functional connectivity (RSFC). Based on animal and human data, we have proposed that AMN supports the brain's action mode by controlling functions required for successful goal-directed behavior. However, task fMRI averaged across groups has associated AMN regions with a variety of behaviors, contributing to uncertainty about AMN function. Here, we investigated the AMN using an inside-out...
• Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum AI翻译
  作者：Widner, James; Faust, Phyllis L.; Louis, Elan D.; Fujita, Hirofumi
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; Columbia University; NewYork-Presbyterian Hospital; NewYork-Presbyterian Hospital; University of Texas System; University of Texas Southwestern Medical Center
  摘要：The cerebellar cortex is organized into discrete regions populated by molecularly distinct Purkinje cells (PCs), the sole cortical output neurons. While studies in animal models have shown that PC subtypes differ in their vulnerability to disease, our understanding of human PC subtype and vulnerability remains limited. Here, we demonstrate that human cerebellar regions specialized for motor vs. cognitive functions (lobule HV vs. Crus I) contain distinct PC populations characterized by specific...
• Epigenetic cellular memory in Pseudomonas aeruginosa generates phenotypic variation in response to host environments AI翻译
  作者：Vatareck, Elisabeth; Rick, Tim; Gomez, Nicolas Oswaldo; Bandyopadhyay, Arnab; Kramer, Janina; Strunin, Dmytro; Erdmann, Jelena; Hartmann, Oliver; Alpers, Kathrin; Boedeker, Christian; Steffen, Anika; Sieben, Christian; Zhao, Gang; Tomasch, Juergen; Haeussler, Susanne
  作者单位：Helmholtz Association; Helmholtz-Center for Infection Research; Hannover Medical School; Helmholtz Association; Helmholtz-Center for Infection Research; University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; Helmholtz Association; Helmholtz-Center for Infection Research; Helmholtz Association; Helmholtz-Center for Infection Research; Helmholtz Association; Helmholtz-Center for Infection Research; Czech Academy of Sciences; Institute of Microbiology of the Czech Academy of Sciences; Hannover Medical School; AstraZeneca
  摘要：Phenotypic diversification within pathogen populations can enhance survival in stressful environments, broaden niche colonization, and expand the ecological range of infectious diseases due to emerging collective pathogenicity characteristics. We describe a gene regulatory network property in the opportunistic pathogen Pseudomonas aeruginosa that generates diversity of gene expression and pathogenicity behavior at the single-cell level and that is stabilized by epigenetic cellular memory. The ...
• Comparing conventional and alternative mechanisms of discovering and accessing the scientific literature AI翻译
  作者：Walters, William H.
  作者单位：Southern Illinois University System; Southern Illinois University
  摘要：This study compares the bibliographic and full- text coverage of 15 conventional and and the Web of Science Core Collection), five single- subject databases, the integrated Scholar), two web- based scholarly databases (Dimensions and OpenAlex), two academic and Sci- Hub). The analysis is based on known- item searches for 875 target documents chology. Overall, Google Scholar, OpenAlex, and the ILS are the most comprehensive sources of bibliographic records. Google Scholar's coverage rate is hig...