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作者：Sun, Jingyao; Yu, Kailiang; Rietkerk, Max; Chen, Ning; Zhang, Hongxia; Song, Guang; Li, Xinrong
作者单位：Chinese Academy of Sciences; Northwest Institute of Eco-Environment & Resources, CAS; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Nanjing Institute of Geology & Paleontology, CAS; Princeton University; Utrecht University; Lanzhou University; Lanzhou University; Xi'an University of Architecture & Technology; Northwest A&F University - China
摘要：Biota could be ecosystem engineers in generating an intrinsic heterogeneous landscape through scale- dependent feedbacks. Thereby, they can form resource- enriched patchiness or islands of fertility, comprising self- organizing spatial patterns. Research so far has largely focused on the self- organized spatial patterns of plant communities in drylands. It, however, remains unclear whether and how biocrusts having distinct morphology and life history from plant communities could self- organize...
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作者：Bolik-Coulon, Nicolas; Rossler, Philip; Nosella, Michael L.; Kim, Tae Hun; Kay, Lewis E.
作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Colorado System; University of Colorado Boulder; University System of Ohio; Case Western Reserve University
摘要：Cellular DNA is wrapped about an octamer composed of four histone proteins forming intrinsically disordered tails of the histones serve as scaffolds for binding an array of proteins that regulate the fidelity of the genome and gene expression. A variety of posttranslational modifications (PTMs) on the tails have been characterized, including some that alter their overall charge; however, per- residue changes in tail electrostatic potentials for different PTMs have not been reported. Here, usin...
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作者：Duncan, Richard P.; Scheele, Ben C.; Clulow, Simon
作者单位：University of Canberra; Australian National University
摘要：Emerging infectious diseases increasingly threaten many wildlife populations, yet the impacts of pathogens vary considerably both within and among host species. The environmental tolerance mismatch hypothesis (ETMH) suggests that this variability stems in part from differences in the relative performance of hosts and pathogens under varying environmental conditions. According to the ETMH, pathogen impacts should be more severe in environments where pathogen performance is high and host perform...
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作者：Lareau, Caleb A.; Maschmeyer, Patrick; Yin, Yajie; Gutierrez, Jacob C.; Dhindsa, Ryan S.; Burrer, Anne - Sophie Gribling -; Zielinski, Sebastian; Hsieh, Yu - Hsin; Nitsch, Lena; Dimitrova, Veronika; Nalbant, Benan; Buquicchio, Frank A.; Abay, Tsion; Stickels, Robert R.; Ulirsch, Jacob C.; Yan, Patrick; Wang, Fangyi; Miao, Zhuang; Sandor, Katalin; Daniel, Bence; Liu, Vincent; Mendez, Paul L.; Knaus, Petra; Meyer, Manpreet; Greenleaf, William J.; Kundaje, Anshul; Smyth, Redmond P.; Munschauer, Mathias; Ludwig, Leif S.; Satpathy, Ansuman T.
作者单位：Memorial Sloan Kettering Cancer Center; Stanford Medicine; Stanford University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Helmholtz Association; Helmholtz-Center for Infection Research; Free University of Berlin; Harvard University; Harvard Medical School; Stanford University; Stanford Medicine; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Stanford University; Ruprecht Karls University Heidelberg
摘要：While somatic variants are well-characterized drivers of tumor evolution, their influence on cellular fitness in nonmalignant contexts remains understudied. We identified a mosaic synonymous variant (m.7076A > G) in the mitochondrial DNA (mtDNA)-encoded cytochrome c-oxidase subunit 1 (MT-CO1, p.Gly391=), present at homoplasmy in 47% of immune cells from a healthy donor. Single-cell multiomics revealed strong, lineage-specific selection against the m.7076G allele in CD8+ effector memory T cells...
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作者：Li, Zhi-Peng; Sun, Xin; Yao, Haifeng; Shangguan, Hua-Yuan; Hu, Hang-Wei; Tang, Zhiyao; Li, Gang; Zhang, Weixin; Delgado-Baquerizo, Manuel; Scheu, Stefan; Zhu, Yong-Guan
作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Melbourne; Peking University; Peking University; Henan University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); University of Gottingen; University of Gottingen
摘要：Land- use changes are reshaping the distribution of aboveground species worldwide. However, the impact of land- use changes on the distribution of soil organisms remains poorly understood. In particular, we lack a mechanistic understanding of the environmental factors reshaping the distribution of soil microbiota in response to global biological homogenization. Here, we used metabarcoding to investigate the biogeography of protists and their relationships with prey and hosts in three human- do...
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作者：Tian, Miaomiao; Hao, Fengqi; Wang, Xinyu; Zheng, Xu; Wang, Huiyue; Li, Jing; Li, Zilin; Xia, Mingjie; Li, Changfeng; Zhao, Zhexuan; Han, Jinling; Li, Dan; Nakabeppu, Yusaku; Boldogh, Istvan; Wei, Min; Ba, Xueqing
作者单位：Northeast Normal University - China; Northeast Normal University - China; Northeast Normal University - China; Jilin University; Jilin University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Kyushu University; University of Texas System; University of Texas Medical Branch Galveston
摘要：8-oxo-7,8-dihydroguanine (8-oxoG), the most frequent form of oxidative-DNA-base lesion caused by ROS, is recognized and repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) through base excision repair (BER) pathway. Beyond its role in DNA repair, OGG1 has been shown to promote transcriptional activation of proinflammatory mediators and contribute to both acute and chronic lung inflammation. However, pioneering studies have shown an anti-inflammation role for OGG1 in inflammatory bowel disease (I...
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作者：Frederick, Jane; Virk, Ranya K. A.; Ye, I. Chae; Almassalha, Luay M.; Wodarcyk, Greta M.; VanDerway, David; Gong, Ruyi; Dunton, Cody L.; Kuo, Tiffany; Medina, Karla I.; Loxas, Margarita; Ahrendsen, Jared T.; Gursel, Demirkan B.; Gonzalez, Paola Carrillo; Nap, Rikkert J.; John, Saira; Agrawal, Vasundhara; Anthony, Nicholas M.; Carinato, John; Li, Wing Shun; Kakkaramadam, Rivaan; Jain, Surbhi; Shahabi, Shohreh; Ameer, Guillermo A.; Szleifer, Igal G.; Backman, Vadim
作者单位：Northwestern University; Northwestern University; Northwestern University; University of California System; University of California San Francisco; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University
摘要：Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications and restructuring of topologically associating domains. However, the underlying principles by which chromatin architecture facilitates such adaptability across different cancers remain poorly understood. To investigate the role of chromatin in this process, we...
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作者：Niwa, Taiki; Uno, Yoshinobu; Ohishi, Yuta; Kadota, Mitsutaka; Aburatani, Naotaka; Kiyatake, Itsuki; Katooka, Daiki; Yorozu, Michikazu; Tsuzuki, Nobutaka; Toyoda, Atsushi; Takagi, Wataru; Nakamura, Masaru; Kuraku, Shigehiro
作者单位：Graduate University for Advanced Studies - Japan; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; RIKEN; Tokushima University; Kobe University; University of Tokyo; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; RIKEN; University of Michigan System; University of Michigan
摘要：Sex determination has been investigated across vertebrate lineages to reveal the stepwise evolution of sex chromosomes and the diversity of responsible molecular mechanisms. However, these studies rarely include cartilaginous fishes, which diverged from the other vertebrates 450 Mya, hindering the comprehensive view of vertebrate sex determination. Here, we produced chromosome-scale genome assemblies of egg-laying shark species and comparatively investigated genome sequences and transcriptome ...
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作者：Viegas, Jennifer
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作者：An, Jiafu; Wang, Tenghui; Chen, Bin; Gong, Peng; Lin, Chen; Stenseth, Nils Chr.
作者单位：University of Hong Kong; Lingnan University; University of Hong Kong; University of Hong Kong; University of Hong Kong; Tsinghua University; University of Oslo; University of Oslo
摘要：Access to safely managed drinking water is a fundamental human right, essential for human health and well- being. However, 2.2 billion people around the world still lack this access, with significant geographical disparities. In this study, we leveraged the implementation of gender quota laws-specifically reserved parliamentary seats for women across African countries-to examine its impact on improved water availability. Our findings reveal that the implementation of gender quotas is associate...
