35期

最新文章

• Radiocarbon dating of Jerusalem's Siloam Dam links climate data and major waterworks AI翻译
  作者：Regev, Johanna; Szanton, Nahshon; Vukosavovic, Filip; Berko, Itamar; Shalev, Yiftah; Uziel, Joe; Mintz, Eugenia; Regev, Lior; Boaretto, Elisabetta
  作者单位：Weizmann Institute of Science
  摘要：Using well-established microarchaeological sampling methods, we reached a precise radiocarbon date of 800 BC for the Siloam Pool's monumental water dam in Jerusalem. This date is a critical link connecting several imposing waterworks constructed at that time. Climate data pointing to droughts and flash floods during the last decades of the 9th century BC provide a logical framework for the reasons behind such endeavors. These included the fortification of the city's primary water source, the G...
• Evolutionarily conserved grammar rules viral factories of amoeba-infecting members of the hyperdiverse Nucleocytoviricota phylum AI翻译
  作者：Rigou, Sofia; Schmitt, Alain; Moreno, Anaisa B.; Lartigue, Audrey; Danner, Lucile; Mayer, Lotte; Giry, Claire; Trabelsi, Feres; Belmudes, Lucid; Olivero-Deibe, Natalia; Le Guenno, Hugo; Coute, Yohann; Berois, Mabel; Legendre, Matthieu; Jeudy, Sandra; Abergel, Chantal; Bisio, Hugo
  作者单位：Aix-Marseille Universite; University of Vienna; CEA; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Pasteur Network; Institut Pasteur de Montevideo; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Universidad de la Republica, Uruguay
  摘要：Despite sharing fewer than 10 core genes, the hyperdiverse Nucleocytoviricota phylum (ranging from poxviruses to giant viruses) universally assembles viral factories (VFs) resembling biomolecular condensates. Regardless, it is unclear how these viruses achieve such a level of functional conservation without clear conserved genetic information. We demonstrate that the VFs produced by amoeba- infecting viruses have liquid- like properties and identify a conserved molecular grammar governing vira...
• DNA2 protein destruction dictates DNA hyperexcision, cGAS- STING activation, and innate immune response in CDK12- deregulated cancers (vol 122,e2413732122,2025) AI翻译
  作者：Sun, Rui; Jiang, Peng; Wang, Zhijun; Yan, Binyuan; Zhu, Shouhai; Huang, Zhenlin; Zhang, Jianong; Ding, Donglin; Li, Xiang; Wang, Liguo; Lou, Zhenkun; Jin, Baiye; Pang, Jun; Huang, Haojie; Xia, Dan
  作者单位：Mayo Clinic
• The US-Israel Blavatnik Scientific Forum on alleviating global water scarcity by desalination and water reuse AI翻译
  作者：Walker, Sharon L.; Dagan, Gedeon; Adin, Avner; Alvarez, Pedro J. J.; Elimelech, Menachem; Radian, Adi
  作者单位：Drexel University; Tel Aviv University; Hebrew University of Jerusalem; Rice University; Rice University; Technion Israel Institute of Technology
• CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis AI翻译
  作者：Yang, Guang; Du, Ximing; Norris, Dougall; Zadoorian, Armella; Zheng, Yuyuan; Gao, Mingming; Brown, Andrew J.; Grey, Shane T.; Zhou, Chun; Yang, Hongyuan
  作者单位：University of New South Wales Sydney; Zhejiang University; Zhejiang University; University of Texas System; University of Texas Health Science Center Houston; George Institute for Global Health; University of New South Wales Sydney
  摘要：The glycerol-3-phosphate (G-3-P) pathway is central to the synthesis of triacylglycerols (TAGs) and glycerophospholipids, essential for membrane biogenesis and lipid storage. The first and rate-limiting step in this pathway is catalyzed by glycerol-3-phosphate acyltransferases (GPATs), with microsomal GPAT3 and GPAT4 being evolutionarily conserved and predominant in most tissues. While previous studies have implicated Calcineurin B homologous protein 1 (CHP1) as a cofactor for GPAT4, the broad...
• Tunable effective diffusion of CO2 in aqueous foam AI翻译
  作者：Aprili, Cecile; Coupier, Gwennou; Lorenceau, Elise; Dollet, Benjamin
  作者单位：Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
  摘要：Aqueous foams are solid materials composed of gases and liquids, exhibiting a large gas/liquid surface area and enabling dynamic exchanges between their fluid components. The structure of binary-gas foams, whose bubbles consist of a mixture of two gases having different affinities with the liquid, thus offers real potential for the dynamic separation of these gases at low cost. In single-gas foams, the structure evolves under the effect of gas flow induced by Laplace pressure differences, aris...
• Echoes in AI: Quantifying lack of plot diversity in LLM outputs AI翻译
  作者：Xu, Weijia; Jojic, Nebojsa; Rao, Sudha; Brockett, Chris; Dolan, Bill
  作者单位：Microsoft
  摘要：With rapid advances in large language models (LLMs), there has been an increasing application of LLMs in creative content ideation and generation. A critical question emerges: can current LLMs provide ideas that are diverse enough to truly bolster collective creativity? We examine two state-of-the-art LLMs, GPT-4 and LLaMA-3, on story generation and discover that LLM-generated stories often consist of plot elements that are echoed across a number of generations. To quantify this phenomenon, we...
• Community detection for directed networks revisited using bimodularity AI翻译
  作者：Cionca, Alexandre; Chan, Chun Hei Michael; Van De Ville, Dimitrivan
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Geneva
  摘要：Community structure is a key feature omnipresent in real-world network data. Plethora of methods have been proposed to reveal subsets of densely interconnected nodes using criteria such as the modularity index. These approaches have been successful for undirected graphs but directed edge information has not yet been dealt with in a satisfactory way. Here, we revisit the concept of directed communities as a mapping between sending and receiving communities. This translates into a definition tha...
• Cognitive dissonance in large language models is neither cognitive nor dissonant AI翻译
  作者：Cummins, Jamie; Elson, Malte; Hussey, Ian
  作者单位：University of Bern; University of Oxford
• Mass support for conserving 30% of the Earth by 2030 Experimental evidence from five continents AI翻译
  作者：Michaelsen, Patrik; Sundstrom, Aksel; Jagers, Sverker C.
  作者单位：University of Gothenburg; Linkoping University
  摘要：Rapid global expansion of protected areas is critical for safeguarding biodiversity but depends on political action for successful implementation. Following widespread ratification of the Kunming-Montreal Global Biodiversity Framework, an unprecedented increase in area-based conservation is required to reach its target of conserving 30% of land, waters, and seas by 2030. These expansions prompt difficult trade-offs between conservation, social, and economic interests. A key factor in securing ...