35期

最新文章

• Using large language models to categorize strategic situations and decipher motivations behind human behaviors AI翻译
  作者：Xie, Yutong; Mei, Qiaozhu; Yuan, Walter; Jackson, Matthew O.
  作者单位：University of Michigan System; University of Michigan; Stanford University; The Santa Fe Institute
  摘要：By varying prompts to a large language model, we can elicit the full range of human behaviors in a variety of different scenarios in classic economic games. By analyzing which prompts elicit which behaviors, we can categorize and compare different strategic situations, which can also help provide insight into what different economic scenarios might induce people to think about. We discuss how this provides a step toward a nonstandard method of inferring (deciphering) the motivations behind the...
• Multistep catalytic abiotic CO2 conversion to sugars through C1 intermediates AI翻译
  作者：Solanda, Nathan; Luoa, Jie; Maulanab, Arifin Luthfi; Feijooa, Julian; Joc, Hye-Jin; Oddoa, Alexander M.; Shanb, Yu; Wanga, Tianle; Leea, Geonhui; Choib, Jihoon; Huynha, Wei-Shan; Guzmana, Maria Fonseca; Jayasinghea, Lihini; Zhub, Cheng; Yanga, Yao; Yanga, Peidong
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Zhejiang University; Seoul National University (SNU); Northwestern University; Cornell University
  摘要：Carbon dioxide (CO2) to multicarbon (Cn) upgrading for commodity chemicals, fuel production, or artificial food synthesis using renewable energy input is a golden target for researchers in sustainable carbon emission reduction. Here, we explore and analyze a flexible modular roadmap for the task, utilizing sequential electro-, photo-, and organocatalysis to develop a strategy for CO2 conversion using the key and elusive formaldehyde precursor of interest for sugar generation. We study the elec...
• Setdb1 ablation in macrophages attenuates fibrosis in heart allografts (Vol 122, e2424534122, 2025) AI翻译
  作者：Ma, Zhibo; Zhou, Xi; Jia, Wenlong; Tan, Xiaosheng; Huang, Xia; Wang, Jingzeng; Sun, Lingjuan; Li, Qingwen; Zhao, Xiangli; Yuan, Naonao; Liu, Ping; Liu, Jing; Chen, Zhishui; Lan, Peixiang
• An information-theoretic foreshadowing of mathematicians' sudden insights AI翻译
  作者：Tabatabaeian, Shadab; O'bi, Artemisia; Landy, David; Marghetis, Tyler
  作者单位：University of California System; University of California Merced; Indiana University System; Indiana University Bloomington; Netflix, Inc.
  摘要：The eureka insights that drive progress in science and mathematics remain shrouded in mystery. Sudden, unexpected, appearing like flashes of lightning, these insights have the hallmarks of critical transitions in complex systems. Here, zooming in on mathematicians working on proofs in their own departments, we show that sudden insights are anticipated by a system-agnostic, information-theoretic early warning signal. Using dense behavioral recordings of mathematicians' moment-to-moment activity...
• Patient stratification reveals the molecular basis of disease co-occurrences AI翻译
  作者：Urda-Garciaa, Beatriz; Sanchez-Valle, Jon; Lepore, Rosalba; Valencia, Alfonso
  作者单位：Universitat Politecnica de Catalunya; Barcelona Supercomputer Center (BSC-CNS); Pompeu Fabra University; University of Basel; University of Basel; ICREA
  摘要：Epidemiological evidence shows that some diseases tend to co-occur; more exactly, certain groups of patients with a given disease are at a higher risk of developing a specific secondary condition. Here, we develop an approach to generate a disease network that uses the accumulating RNA-seq data on human diseases to significantly match an unprecedented proportion of known comorbidities, providing plausible biological models for such co-occurrences and effectively mirroring the underlying struct...
• Ingroup solidarity drives social media engagement after political crises AI翻译
  作者：Marks, Malia; Kyrychenko, Yara; Gardebo, Johan; Roozenbeek, Jon
  作者单位：University of Cambridge; University of Cambridge
  摘要：Social media are often said to exacerbate polarization by platforming hostility between groups. However, positive social emotions like ingroup solidarity may also drive social media engagement, particularly after major threats such as military invasions or terror attacks. In this preregistered study, we examine the socioemotional drivers of engagement following group threats in the context of the US 2024 presidential campaign trail, where both major political parties faced crises in July of 20...
• Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice (vol 110. pg E4213, 2013) AI翻译
  作者：Kalakonda, Sudhakar; Nallar, Shreeram C.; Jaber, Sausan; Keay, Susan K.; Rorke, Ellen; Munivenkatappa, Raghava; Lindner, Daniel J.; Fiskum, Gary M.; Kalvakolanu, Dhananjaya V.
• Rising global temperatures reduce soil microbial diversity over the long term AI翻译
  作者：Sun, Yuan; Chen, Han Y. H.; Chen, Xin; Hisano, Masumi; Chen, Xinli; Reich, Peter B.
  作者单位：Yancheng Teachers University; Lakehead University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University System of Maryland; University of Maryland Center for Environmental Science; Hiroshima University; Zhejiang A&F University; University of Minnesota System; University of Minnesota Twin Cities; Western Sydney University
  摘要：Soil microbial diversity is crucial to sustaining ecosystem productivity and improving carbon sequestration. Global temperature continues to rise, but how climate warming affects microbial diversity and its capacity to sequester soil organic carbon (SOC) remains uncertain. Here, by conducting a global meta-analysis with 251 paired observations from 102 studies, we showed that, on average, warming reduced bacterial and fungal diversity (measured by richness and Shannon index) by 16.0 and 19.7%,...
• Ovarian germline stem cell dedifferentiation is cytoneme dependent AI翻译
  作者：Sutcliffe, Catherine; Nandy, Nabarun; Revici, Raluca; Johnson, Heather; Habib, Shukry J.; Ashe, Hilary L.; Wilcockson, Scott G.
  作者单位：University of Manchester; Francis Crick Institute
  摘要：Progenitor cell dedifferentiation is important for stem cell maintenance during tissue repair and age- related stem cell decline. Here, we use the Drosophila ovary as a model to study the role of cytonemes in bone morphogenic protein (BMP) signaling-directed provide evidence that differentiating germ cell cysts extend longer cytonemes that are more polarized toward the niche during dedifferentiation to reactivate BMP signaling. The presence of additional somatic cells in the niche is associate...
• Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases AI翻译
  作者：Tran, Norman; Frenette, Aaron; Holyoak, Todd
  作者单位：University of Waterloo
  摘要：Immunoglobulin A proteases (IgAPs) are a diverse group of enzymes secreted from bacteria that inhabit human mucosal tissues. These enzymes have convergently evolved to cleave human immunoglobulin A as a means of modulating and evading host immunity. Only two of three known IgAP families have been biochemically characterized beyond their initial discovery. Here, we show using solution-scattering, steady-state kinetic, and crystallographic approaches that the protease from Thomasclavelia ramosa,...