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作者：Li, Min; Zhang, Qi; Kong, Xi; Zhao, Sheng; Pan, Bin-Bin; Sun, Ziting; Yu, Pei; Wang, Zhecheng; Wang, Mengqi; Ji, Wentao; Kong, Fei; Cheng, Guanglei; Wu, Si; Wang, Ya; Chen, Sanyou; Su, Xun-Cheng; Shi, Fazhan
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Zhejiang University; Nanjing University; Nankai University; Nankai University; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：The investigation of biomolecular interactions at the single-molecule level has emerged as a pivotal research area in life science, particularly through optical, mechanical, and electrochemical approaches. Spins existing widely in biological systems offer a unique degree of freedom for detecting such interactions. However, most previous studies have been largely confined to ensemble-level detection in the spin degree. Here, we developed a molecular interaction analysis method approaching singl...
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作者：Lu, Muyang; Yanco, Scott W.; Carlson, Ben S.; Winner, Kevin; Cohen, Jeremy M.; Soto, Diego; Sharma, Shubhi; Rogers, Will; Jetz, Walter
作者单位：Sichuan University; Yale University; Yale University; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; Yale University; Rutgers University System; Rutgers University New Brunswick; University of California System; University of California Berkeley
摘要：The niche is a key concept that unifies ecology and evolutionary biology. However, empirical and theoretical treatments of the niche are mostly performed at the species level, neglecting individuals as important units of ecological and evolutionary processes. So far, a formal mathematical link between individual-level niches and higher organismal-level niches has been lacking, hampering the unification of ecological theories and more accurate forecasts of biodiversity change. To fill in this g...
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作者：Marin-Rodero, Miguel; Jayewickreme, Teshika; Benoist, Christophe; Mathis, Diane
作者单位：Harvard University; Harvard Medical School
摘要：The Foxp3+CD4+ regulatory T cells (Tregs) generated around birth are phenotypically and functionally distinct from those engendered during adulthood. That perinatally produced Tregs persist for a protracted period in peripheral lymphoid organs has been well documented, as has their superior ability to protect the organism from many autoimmune diseases. However, their contribution to pools of nonlymphoid-tissue Tregs and their homeostatic functions therein have been little studied. We show that...
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作者：Merow, Cory; Maitner, Brian S.; Meyer, Andreas Schwarz; Pigot, Alex L.; Serra-Diaz, Josep M.; Urban, Mark C.
作者单位：University of Connecticut; University of Connecticut; University of Connecticut; State University System of Florida; University of South Florida; University of Cape Town; University of London; University College London; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Institut Botanic de Barcelona (ICUB)
摘要：As climate change accelerates, effectively monitoring and managing the growing impacts on biodiversity is an urgent priority. Here, we identify the exposure of species to unprecedented heat to evaluate the potential impact of 2024-the hottest year on record- across >33,000 vertebrate species worldwide. One in six (5,368) species were exposed to unprecedented temperatures across >25% of their range-68% more species than in 2023. Most (81%) species exposed in 2023 were also exposed in 2024, pote...
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作者：Kalakonda, Sudhakar; Nallar, Shreeram C.; Jaber, Sausan; Keay, Susan K.; Rorke, Ellen; Munivenkatappa, Raghava; Lindner, Daniel J.; Fiskum, Gary M.; Kalvakolanu, Dhananjaya V.
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作者：Sun, Yuan; Chen, Han Y. H.; Chen, Xin; Hisano, Masumi; Chen, Xinli; Reich, Peter B.
作者单位：Yancheng Teachers University; Lakehead University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University System of Maryland; University of Maryland Center for Environmental Science; Hiroshima University; Zhejiang A&F University; University of Minnesota System; University of Minnesota Twin Cities; Western Sydney University
摘要：Soil microbial diversity is crucial to sustaining ecosystem productivity and improving carbon sequestration. Global temperature continues to rise, but how climate warming affects microbial diversity and its capacity to sequester soil organic carbon (SOC) remains uncertain. Here, by conducting a global meta-analysis with 251 paired observations from 102 studies, we showed that, on average, warming reduced bacterial and fungal diversity (measured by richness and Shannon index) by 16.0 and 19.7%,...
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作者：Sutcliffe, Catherine; Nandy, Nabarun; Revici, Raluca; Johnson, Heather; Habib, Shukry J.; Ashe, Hilary L.; Wilcockson, Scott G.
作者单位：University of Manchester; Francis Crick Institute
摘要：Progenitor cell dedifferentiation is important for stem cell maintenance during tissue repair and age- related stem cell decline. Here, we use the Drosophila ovary as a model to study the role of cytonemes in bone morphogenic protein (BMP) signaling-directed provide evidence that differentiating germ cell cysts extend longer cytonemes that are more polarized toward the niche during dedifferentiation to reactivate BMP signaling. The presence of additional somatic cells in the niche is associate...
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作者：Tran, Norman; Frenette, Aaron; Holyoak, Todd
作者单位：University of Waterloo
摘要：Immunoglobulin A proteases (IgAPs) are a diverse group of enzymes secreted from bacteria that inhabit human mucosal tissues. These enzymes have convergently evolved to cleave human immunoglobulin A as a means of modulating and evading host immunity. Only two of three known IgAP families have been biochemically characterized beyond their initial discovery. Here, we show using solution-scattering, steady-state kinetic, and crystallographic approaches that the protease from Thomasclavelia ramosa,...
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作者：Altshuler, Boris L.; Kravtsov, Vladimir E.; Scardicchio, Antonello; Sierant, Piotr; Vanoni, Carlo
作者单位：Columbia University; Abdus Salam International Centre for Theoretical Physics (ICTP); Istituto Nazionale di Fisica Nucleare (INFN); Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); International School for Advanced Studies (SISSA)
摘要：We discuss the dependence of the critical properties of the Anderson model on the dimension d in the language of /3-function and renormalization group recently introduced in Vanoni et al. [C. Vanoni et al., Proc. Natl. Acad. Sci. U.S.A. 121, e2401955121 (2024)] in the context of Anderson transition on random regular graphs. We show how in the delocalized region, including the transition point, the one-parameter scaling part of the /3-function for the fractal dimension D1 evolves smoothly from ...
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作者：Langlois, Jill
