-
作者：Lawton, Ralph
作者单位：Harvard University
摘要：Exposure to infectious disease in early life may have long-term ramifications for health and lifespan. However, reducing pathogen exposure may not be uniformly beneficial. The rise of modern sanitation and reduction of infectious diseases has been implicated in increasing levels of allergy and immune dysregulation: termed, the hygiene hypothesis. This study leverages quasi-experimental variation from combining precampaign hookworm exposure with the Rockefeller Sanitary Commission's deworming c...
-
作者：Nuovo, Gerard J.; Tili, Esmerina; Croce, Carlo M.
作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute
摘要：Human papillomavirus (HPV)-related lesions contain types with benign outcomes and those with a risk of progression to cancer. We addressed the role of immune surveillance in 76 cervical biopsies (normal = 23, HPV+ benign = 16, HPV+ precancer = 37) by studying the infiltration of cytotoxic T cells and the expression of the immune modulators PDL1, ICOSL, and miR-155 and compared the data to 101 cervical squamous cell carcinomas. In the normal cervix, ICOSL expression was restricted to the endoce...
-
作者：Cho, Hanbyul; Zhang, Yuping; Tien, Jean C.; Mannan, Rahul; Luo, Jie; Narayanan, Sathiya Pandi; Mahapatra, Somnath; Hu, Jing; Shelley, Greg; Cruz, Gabriel; Shahine, Miriam; Wang, Lisha; Su, Fengyun; Wang, Rui; Cao, Xuhong; Dhanasekaran, Saravana Mohan; Keller, Evan T.; Pitchiaya, Sethuramasundaram; Chinnaiyan, Arul M.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Shandong University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Howard Hughes Medical Institute; University of Michigan System; University of Michigan
摘要：Inadequate response to androgen deprivation therapy (ADT) frequently arises in prostate cancer, driven by cellular mechanisms that remain poorly understood. Here, we integrated single- cell RNA sequencing, single- cell multiomics, and spatial transcriptomics to define the transcriptional, epigenetic, and spatial basis of cell identity and castration response in the mouse prostate. Leveraging these data along with a meta- analysis of human prostates and prostate cancer (PCa), we identified cell...
-
作者：[Anonymous]
摘要：Global demand for wood products is increasing forest harvest. One understudied consequence of logging is that it accelerates mobilization of dissolved organic matter (DOM) from soils to aquatic ecosystems where it is more easily rereleased to the atmosphere. Here, we tested how logging changed DOM in headwaters of hardwood-dominated catchments in northern Ontario, Canada. We applied a before-after-control-impact experiment across four catchments for 3 y and measured DOM monthly during ice-free...
-
作者：Bubphamanee, Kunmanee; Kipp, Michael A.; Meixnerova, Jana; Stueken, Eva E.; Ivany, Linda C.; Bartholomew, Alexander J.; Algeo, Thomas J.; Brocks, Jochen J.; Dahl, Tais W.; Kinsley, Jordan; Tissot, Francois L. H.; Buick, Roger
作者单位：University of Washington; University of Washington Seattle; National Aeronautics & Space Administration (NASA); California Institute of Technology; Duke University; University of St Andrews; Syracuse University; State University of New York (SUNY) System; SUNY New Paltz; University System of Ohio; University of Cincinnati; China University of Geosciences; Chengdu University of Technology; Australian National University; University of Copenhagen
摘要：The oxygenation history of Earth's surface environments has had a profound influence on the ecology and evolution of metazoan life. It was traditionally thought that the Neoproterozoic Oxygenation Event enabled the origin of animals in marine environments, followed by their persistence in aerobic marine habitats ever since. However, recent studies of redox proxies (e.g., Fe, Mo, Ce, I) have suggested that low dissolved oxygen levels persisted in the deep ocean until the Late Devonian, when the...
-
作者：Lopez- Cubillos, Sofia; Mason, Natalie; Wintle, Brendan; Pacheco, Pablo; Ochoa-Quintero, Jose Manuel; Nascimento, Nathalia; Torres, Bolier; Runting, Rebecca K.
作者单位：University of Melbourne; University of Melbourne; World Wildlife Fund; Universidade Federal de Mato Grosso do Sul; Universidade de Sao Paulo
-
作者：Altshuler, Boris L.; Kravtsov, Vladimir E.; Scardicchio, Antonello; Sierant, Piotr; Vanoni, Carlo
作者单位：Columbia University; Abdus Salam International Centre for Theoretical Physics (ICTP); Istituto Nazionale di Fisica Nucleare (INFN); Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); International School for Advanced Studies (SISSA)
摘要：We discuss the dependence of the critical properties of the Anderson model on the dimension d in the language of /3-function and renormalization group recently introduced in Vanoni et al. [C. Vanoni et al., Proc. Natl. Acad. Sci. U.S.A. 121, e2401955121 (2024)] in the context of Anderson transition on random regular graphs. We show how in the delocalized region, including the transition point, the one-parameter scaling part of the /3-function for the fractal dimension D1 evolves smoothly from ...
-
作者：Langlois, Jill
-
作者：Stephens, Dylon R.; Fung, Ho Yee Joyce; Han, Yan; Liang, Jue; Chen, Zhe; Ready, Joseph; Collins, James J.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
摘要：Schistosomes are parasitic flatworms that infect more than 200 million people globally. However, there is a shortage of molecular tools that enable the discovery of potential drug targets within schistosomes. Thus, praziquantel has remained the frontline treatment for schistosomiasis despite known liabilities. Here, we have conducted a genome- wide study in Schistosoma mansoni using the human druggable genome as a bioinformatic template to identify essential genes within schistosomes bearing s...
-
作者：Jankovic, Matija; Kang, Seungmin; Bhattacharya, Sarnab; Kashanchi, Jordon; Wang, Jieting; Deoli, Kanika; Huang, Tianda; Johnson, Alex; Ambani, Karina; Kim, Sangjun; Wang, Pulin; Coyle, Edward; Lu, Nanshu
