35期

最新文章

• Reply to Cummins et al.: GPT reveals cognitive dissonance that is both irrational and alarmingly humanlike AI翻译
  作者：Lehr, Steven A.; Saichandran, Ketan S.; Harmon-Jones, Eddie; Vitali, Nykko; Banaji, Mahzarin R.
  作者单位：Boston University; University of New South Wales Sydney; Harvard University
• Specificities of chemosensory receptors in the human gut microbiota AI翻译
  作者：Xu, Wenhao; Khayrova, Ekaterina Jalomo -; Gumerov, Vadim M.; Ross, Patricia A.; Kobel, Tania S.; Schindler, Daniel; Bange, Gert; Zhulin, Igor B.; Sourjik, Victor
  作者单位：Max Planck Society; Philipps University Marburg; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：The human gut is rich in metabolites and harbors a complex microbial community, yet surprisingly little is known about the spectrum of chemical signals detected by the large variety of sensory receptors present in the gut microbiome. Here, we systematically mapped the ligand specificities of selected extracytoplasmic sensory domains from twenty members of the human gut microbiota, with a primary focus on the abundant and physiologically important class of Clostridia. Twenty- five metabolites f...
• Flavin-deficient erythrocytes offer protection against malaria parasites AI翻译
  作者：Hemasa, Ayman; van Loon, Welmoed; Fu, Jonathan; Spry, Christina; Jager, Julia; van Schalkwyk, Donelly A.; Reverberi, Roberto; Ndoli, Jules; Mockenhaupt, Frank P.; Contini, Carlo; Saliba, Kevin J.
  作者单位：Australian National University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; University of Ferrara; Arcispedale Sant'Anna; University of Ferrara
  摘要：Studies from the 1980s and 1990s conducted in Italy, where malaria was once endemic, hypothesized that individuals with erythrocytes deficient in flavin mononucleotide and flavin adenine dinucleotide (FAD)-collectively known as flavins-are partially protected against malaria. The condition was reported to be familial, consistent with a genetic element. This hypothesis, however, has never been tested. Using an erythrocyte FAD-dependent glutathione reductase activity assay, we identified individ...
• Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants AI翻译
  作者：Wang, Siling; Sun, Hui; Wang, Yizhen; Wang, Zikang; Yuan, Lunzhi; Guo, Huilin; Gao, Jiahua; Lan, Miaolin; Wu, Yangtao; Shang, Huixian; Chen, Xiuting; Chen, Zheng; Hu, Jiayi; Tang, Zimin; Wen, Guiping; Ying, Dong; Liu, Chang; Jiang, Yanan; Su, Jinfu; Lin, Min; Wu, Ting; Li, Shaowei; Zhang, Tianying; Zhang, Jun; Guan, Yi; Yuan, Quan; Xia, Ningshao; Zheng, Qingbing; Zhang, Yali; Zheng, Zizheng
  作者单位：Xiamen University; Xiamen University; Xiamen University; University of Hong Kong; Shantou University; Shantou University; University of Hong Kong; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) bivalent vaccines show potential against variants but lack a full understanding of the immunological mechanisms that drive broadly neutralizing antibodies (bnAbs). This study explored the immunogenicity of a bivalent vaccine in rhesus macaques, containing spike (S) proteins from the prototype (Sprototype) and chimeric S protein (S1628x). The vaccine induced bnAbs against multiple variants, including challenging subvariants like EG.1, ...
• Parallel trade-offs in human cognition and neural networks: The dynamic interplay between in-context and in-weight learning AI翻译
  作者：Russin, Jacob; Pavlick, Ellie; Frank, Michael J.
  作者单位：Brown University; Brown University; Brown University
  摘要：Human learning embodies a striking duality: Sometimes, we can rapidly infer and compose logical rules, benefiting from structured curricula (e.g., in formal education), while other times, we rely on an incremental approach or trial-and-error, learning better from curricula that are randomly interleaved. Influential psychological theories explain this seemingly conflicting behavioral evidence by positing two qualitatively different learning systems-one for rapid, rule-based inferences (e.g., in...
• Impact of women's political empowerment through gender quotas on improved drinking water access in Africa (vol 122 , e2511977122, 2025) AI翻译
  作者：An, Jiafu; Wang, Tenghui; Chen, Bin; Gong, Peng; Lin, Chen; Stenseth, Nils Chr.
  作者单位：University of Hong Kong; Lingnan University; University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; Tsinghua University; University of Oslo; University of Oslo
• Interfacial electroneutrality controls transport of asymmetric salts through charge-patterned mosaic membranes AI翻译
  作者：Gao, Feng; Hoffman, John R.; Xu, Jialing; Ievlev, Anton, V; Whitmer, Jonathan K.; Phillip, William A.
  作者单位：University of Notre Dame; United States Department of Energy (DOE); Oak Ridge National Laboratory; Center for Nanophase Materials Sciences
  摘要：Membranes that selectively enhance target solute permeation while rejecting competing species are essential for precision separations. This study introduces charge-patterned mosaic membranes (CMMs) that selectively transport divalent asymmetric salts by leveraging a net-neutral membrane-solution interface. This mechanism, dictated by the charge ratio of positive and negative domains on the membrane surface and the balance of cations and anions in the salt, is supported by analytical, numerical...
• BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza (vol 122, e2424367122, 2025) AI翻译
  作者：Soni, Sourabh; Yildiz, Soner; Allen, Emma Kaitlynn; Petersen, Hans; Peeples, Mark; El Zahed, Sara; Rosas, Lorena; Anang, Vandana; Antonescu, Laura; Nho, Richard Seonghun; Mora, Ana Lucia; Horowitz, Jeffrey Craig; Rojas, Mauricio; Medina, Rafael Andres; Thomas, Paul Glyndwr; Garcia-Sastre, Adolfo; Tesfaigzi, Yohannes; Mebratu, Yohannes Afework
• Local c- di- GMP signaling, triggered by cross- regulation of cAMP- CRP and c- di- GMP, controls biofilm formation under nutrient limitation AI翻译
  作者：Sun, Di; Liu, Xiaobo; Zhang, Ying; Shi, Rui; Ru, Yunrui; Zhou, Xuge; Chen, Ying; Yang, Jing; Liu, Jiawen; Zhu, Jingrong; Liu, Cong; Liu, Weijie
  作者单位：Jiangsu Normal University; Nanjing University of Science & Technology; Beijing Institute of Technology
  摘要：Bacteria have several nucleotide second messengers, most of which act as global regulators to control a wide range of bacterial physiological processes. Studies usually focus on a single second messenger, and the mechanisms and physiological significance of the cross-regulation between different nucleotide second messengers are often unclear. Here, we show that Shewanella putrefaciens can form biofilms in both nutrient-rich and nutrient-poor media. While both are controlled by c-di-GMP, the re...
• Organoid- based neutralization assays reveal a distinctive profile of SARS- CoV-2 antibodies and recapitulate the real- world efficacy AI翻译
  作者：Wan, Zhixin; Li, Cun; Zhou, Ying; Yu, Yifei; Chiu, Man Chun; Huang, Jingjing; Zhang, Shuxin; Zhu, Xiaoxin; Lan, Qiaoshuai; Deng, Yanlin; Xue, Wei; Jiang, Chengfan; Wu, Jiali; Zhao, Zijun; Cai, Jian-Piao; Huang, Lin; Zhang, Yong; Liu, Xiaojuan; Zhang, Zheng; Chu, Hin; Zhang, Linqi; Chen, Zhiwei; To, Kelvin Kai-Wang; Yuen, Kwok-Yung; Clevers, Hans; Zhou, Jie
  作者单位：University of Hong Kong; Peking University; The Third People's Hospital of Shenzhen; University of Hong Kong; University of Hong Kong; Tsinghua University; Tsinghua University; Tsinghua University; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; Roche Holding
  摘要：The efficacy of VIR-7831, a class 3 anti-SARS-CoV-2 monoclonal antibody (mAb), was demonstrated repeatedly in clinical trials; yet, reduced neutralization against Omicron variants in cell-line-based neutralization assays led to its withdrawal from clinical use. We developed organoid-based neutralization assays to measure mAb potency. We found that most class 3 mAbs, especially those not blocking receptor-binding domain-ACE2 binding, including VIR-7831, were substantially underestimated in cell...