35期

最新文章

• Substantial reductions in black carbon from both fossil fuels and biomass burning during China's Clean Air Action AI翻译
  作者：Liu, Junwen; Jiang, Fan; Wang, Qiongqiong; Zhang, Gan; Li, Jun; Chen, Weihua; Ding, Ping; Zhu, Sanyuan; Cheng, Zhineng; Zhang, Xiangyun; Sha, Qinge; Huang, Zhijiong; Yuan, Xin; Zheng, Junyu; Zhang, Yanlin; Yan, Caiqing; Tian, Chongguo; Chen, Yingjun; Yu, Jian Zhen; Gustafsson, Orjan
  作者单位：Jinan University; Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Hong Kong University of Science & Technology; Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Hong Kong University of Science & Technology; Nanjing University of Information Science & Technology; Shandong University; Chinese Academy of Sciences; Yantai Institute of Coastal Zone Research, CAS; Fudan University; Hong Kong University of Science & Technology; Stockholm University; Stockholm University
  摘要：Black carbon (BC) aerosols exacerbate air pollution and climate warming, but their climatic impacts and sources are poorly constrained by bottom-up emission inventories (EIs). China's Clean Air Action (CAA), which was launched in 2013, provides an excellent opportunity for investigating interannual variations in source contributions and validate the accuracy of EIs. Here, we present an 11-y (2008-2018) record of the BC concentration and its source-diagnostic radiocarbon (14C) and stable carbon...
• An exploration of basic human values in 38 million obituaries over 30 years AI翻译
  作者：Markowitz, David M.; Mazzuchi, Thomas; Syropoulos, Stylianos; Law, Kyle Fiore; Young, Liane
  作者单位：Michigan State University; Boston College; Arizona State University; Arizona State University-Tempe
  摘要：How societies remember the dead can reveal what people value in life. We analyzed 38 million obituaries from the United States to examine how personal values are encoded in individual and collective legacies. Using Schwartz's theory of basic human values, we found that tradition and benevolence dominated legacy reflections, while values like power and stimulation appeared less frequently. Major cultural events-the terrorist attacks of September 11th, the 2008 financial crisis, and the COVID-19...
• ARRDC4-mediated glycolysis enhances innate immunity to influenza A virus through fructose-1,6-bisphosphate AI翻译
  作者：Li, Yuhan; Wang, Zhen; Wang, Jie; Jiang, Zhimin; Chen, Mingyue; Ai, Hui; Ma, Chao; Tong, Qi; Liu, Litao; Velkov, Tony; Sun, Honglei; Pu, Juan; Liu, Jinhua; Dai, Chongshan; Sun, Yipeng
  作者单位：China Agricultural University; China Agricultural University; Monash University
  摘要：Glucose metabolism impacts the innate immune response against viral infection. However, the key enzymes or the natural products and mechanisms involved are not well elucidated. Here, we found that arrestin domain containing 4 (ARRDC4), a critical regulator of glucose metabolism, senses influenza A virus (IAV) infection by interacting with viral PA protein. Upregulated ARRDC4 increases the enzymatic activity of phosphofructokinase, muscle type (PFKM) via binding its His298 site to promote the p...
• Symbiosis with and mimicry of corals were facilitated by immune gene loss and body remodeling in the pygmy seahorse AI翻译
  作者：Qu, Meng; Zhang, Yingyi; Woltering, Joost; Liu, Yali; Liu, Zixuan; Wan, Shiming; Jiang, Han; Yu, Haiyan; Chen, Zelin; Wang, Xin; Zhang, Zhixin; Qin, Geng; Schneider, Ralf; Meyer, Axel; Lin, Qiang
  作者单位：Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; University of Konstanz; University of Kiel; Harvard University
  摘要：A remarkable example of symbiosis involves the pygmy seahorse (Hippocampus bargibanti). It lives obligatorily on gorgonian corals, mimicking their polyps with pink coloration and skin protuberances. Unique for seahorses, pygmy seahorses retain juvenile paedomorphic stunted snouts, resembling the coral's polyps. We analyzed the tiny seahorse's genome revealing the genomic bases of several adaptations to their mutualistic life including substantial reductions in conserved noncoding elements that...
• Single- strand DNA is the link between neutrophil extracellular traps and thrombin AI翻译
  作者：Jenne, Craig; Kubes, Paul
  作者单位：University of Calgary; University of Calgary; Queens University - Canada
• STAGE: A compact and versatile TnpB-based genome editing toolkit for Streptomyces AI翻译
  作者：Luo, Jing; Chia, Natalie; Qin, Yuxi; Tan, Pan; Zhang, Lingwen; Yang, Sihan; Yuan, Zihan; Hong, Liang; Lee, Sang Yup; Tong, Yaojun
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Streptomyces are naturally endowed with the capacity to produce a wide array of natural products with biomedical and biotechnological value. They have garnered great interest in synthetic biology applications given the abundance of uncharacterized biosynthetic gene clusters (BGCs). However, progress has been hindered by the limited availability of genetic tools for manipulating these bacteria. Several representative CRISPR-Cas systems have been established in Streptomyces to streamline experim...
• Sociohydrodynamics: Data-driven modeling of social behavior AI翻译
  作者：Seara, Daniel S.; Colen, Jonathan; Fruchart, Michel; Avni, Yael; Martin, David G.; Vitelli, Vincenzo
  作者单位：University of Chicago; University of Chicago; Old Dominion University; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); University of Chicago; University of Chicago
  摘要：Living systems display complex behaviors driven by physical forces as well as decisionof socially generated collective behaviors. However, the construction of such theories is often divorced from the data they should describe. Here, we develop and apply a data-driven pipeline that links micromotives to macrobehavior by augmenting hydrodynamics with individual preferences that guide motion. We illustrate this pipeline on a case study of residential dynamics in the United States, for which censu...
• Quantum metric-induced giant and reversible nonreciprocal transport phenomena in chiral loop-current phases of kagome metals AI翻译
  作者：Tazai, Rina; Yamakawa, Youichi; Morimoto, Takahiro; Kontani, Hiroshi
  作者单位：Kyoto University; Nagoya University; University of Tokyo
  摘要：Emergence of quantum orders with nontrivial quantum geometric properties in metals represent central issues in condensed matter physics. In this context, recently discovered chiral loop-current order in kagome metals has garnered significant attention. Particularly noteworthy is the giant electrical magnetochiral anisotropy (eMChA) observed in CsV3Sb5, which provides compelling evidence for the simultaneous breaking of time-reversal and inversion symmetries. However, the origin of the eMChA an...
• STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling AI翻译
  作者：Horvath, Ferdinand; Jung, Hendrik; Grabmayr, Herwig; Fahrner, Marc; Romanin, Christoph; Hummer, Gerhard
  作者单位：Johannes Kepler University Linz; Max Planck Society; Johannes Kepler University Linz; Goethe University Frankfurt; Institute of Science & Technology - Austria
  摘要：Stromal interaction molecule 1 (STIM1) is a Ca2+-sensing protein in the endoplasmic reticulum (ER) membrane. The depletion of ER Ca2+ stores induces a large conformational transition of the cytosolic STIM1 C-terminus, initiated by the dimerization of the transmembrane (TM) domain. We use the AI-guided transition path sampling algorithm aimmd to extensively sample the dimerization of STIM1-TM helices in an ER-mimicking lipid bilayer. In nearly 0.5 ms of all-atom molecular dynamics simulations w...
• Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice AI翻译
  作者：Keck, Carl H. C.; Schmidt, Elizabeth L.; Roth, Richard H.; Floyd, Brendan M.; Tsai, Andy P.; Garcia, Hassler B.; Cui, Miao; Chen, Xiaoyu; Wang, Chonghe; Park, Andrew; Zhao, Su; Liao, Pinyu A.; Casey, Kerriann M.; Reineking, Wencke; Cai, Sa; Zhang, Ling - Yi; Yang, Qianru; Yuan, Lei; Baghdasaryan, Ani; Lopez, Eduardo R.; Cooper, Lauren; Cui, Han; Esquivel, Daniel; Brinson, Kenneth; Chen, Xiaoke; Wyss-Coray, Tony; Coleman, Todd P.; Brongersma, Mark L.; Bertozzi, Carolyn R.; Wang, Gordon X.; Ding, Jun B.; Hong, Guosong
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely absorbing dye molecules, which created transparency in the red spectrum while blocking shorter- wavelength photons. In this paper, we extend this capability to achieve optical transparency across the entire visible spectrum by employing molecules with strong absorption in the ultraviolet spectrum...