-
作者：Yang, Rui; Si, Qiaoling; Sheng, Qiang; Yang, Mingyang; Du, Mu; Zhang, Hu; Shi, Xiao-Lei; Tang, Guihua; Chen, Zhi-Gang
作者单位：Xi'an Jiaotong University; Shandong University; Xi'an Jiaotong University; Queensland University of Technology (QUT); Queensland University of Technology (QUT)
摘要：Nanoporous structures play a critical role in a wide range of applications, including catalysis, thermoelectrics, energy storage, gas adsorption, and thermal insulation. However, their thermal instability remains a persistent challenge. Inspired by the extraordinary resilience of tardigrades, an atomic armor strategy is introduced to enhance the stability of nanoporous structures. Applied to mesoporous silica at parts-per-million levels, the atomic armor provides thermal resistance exceeding t...
-
作者：Kumar, Vrinda Ravi; Buddh, Shyamsunder; Singhal, Shivansh; Prakash, Arun; Agashe, Deepa
作者单位：Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; Michigan State University
摘要：Evolutionary rescue helps populations survive environmental change, but the phenotypic and demographic factors associated with rescue dynamics and its long-term effects remain unclear. We experimentally evolved 10 wild-collected populations of flour beetles from across India in a suboptimal corn resource for 70 generations (>5 y), collecting >10,000 population census points book-ended by measurements of fitness-related traits for 30 experimental lines. Despite clear ancestral trait differences...
-
作者：Afzal, Junaid; Suhail, Yasir; Du, Wenqiang; Liu, Yamin; Ramasamy, Ramalakshmi; Liu, Zukai; Goyal, Ruchi; Novin, Ashkan; Suhail, Sameera; Maziarz, Jamie; Wali, Khadija; Robson, Paul; Wagner, Gunter P.; Kshitiz
作者单位：University of California System; University of California San Francisco; University of Connecticut; Jackson Laboratory; Yale University; Yale University
摘要：Coopetition is a term from game theory that describes a mix of cooperative and competitive behavior. The maternal-fetal interface (MFI) among eutherian mammals presents close interaction of two distinct individuals. These interactions have resulted in a remarkable diversity in MFI structure, often interpreted as the outcome of maternal-fetal conflict. Nevertheless, the fetus and the mother share evolutionary interests since 50% of fetal genes are maternal. In hemochorial species, characterized...
-
作者：Ando, Jun; Murai, Kazue; Michiyuki, Tomoe; Takahashi, Ikuko; Iida, Tatsuya; Kogo, Yasushi; Toyoda, Masashi; Saito, Yuko; Murayama, Shigeo; Kurihara, Masanori; Watanabe, Rikiya
作者单位：RIKEN
摘要：Digital bioanalysis enables highly sensitive detection of biomolecules at the single-molecule level, making it a widely used technique in biomedical research. However, conventional approaches typically rely on fluorescence detection of single-enzyme reactions, which limits molecular selectivity and the ability to analyze multiple targets simultaneously. To address these limitations, we developed a digital bioanalysis platform based on surface-enhanced Raman scattering spectroscopy and microcha...
-
作者：Mittal, Anshumali; Martin, Matthew F.; Provins, Laurent; Hall, Adrian; Ledecq, Marie; Wolff, Christian; Gillard, Michel; Horanyi, Peter S.; Coleman, Jonathan A.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; UCB Pharma SA
摘要：Brivaracetam (BRV) and levetiracetam (LEV) are antiseizure medications (ASMs); UCB-J is a PET tracer targeting synaptic vesicle protein 2A (SV2A); UCB7361 is closely related to padsevonil, an experimental anticonvulsant; while UCB1244283 acts as an allosteric modulator for BRV and LEV binding but not for these other ligands. The SV2A-BRV-UCB1244283 structure reveals how UCB1244283 allosterically enhances BRV binding by occupying an allosteric site near the primary binding site, preventing BRV ...
-
作者：Faber, Justin; Alampounti, Alexandros C.; Georgiades, Marcos; Albert, Joerg T.; Bozovic, Dolores
作者单位：University of California System; University of California Los Angeles; University of London; University College London; Carl von Ossietzky Universitat Oldenburg; University of California System; University of California Los Angeles
摘要：Distortion products are tones produced through nonlinear effects of a system simultaneously detecting two or more frequencies. These combination tones are ubiquitous to vertebrate auditory systems and are generally regarded as byproducts of nonlinear signal amplification. It has previously been shown that several species of infectious-disease-carrying mosquitoes utilize these distortion products for detecting and locating potential mates. Furthermore, the mechanical tuning curve of the male mo...
-
作者：Pang, Xiaoyun; Zhang, Yan; Park, Kunyou; Liao, Zhenyu; Li, Jian; Xu, Jiashu; Hong, Minh-Triet; Yin, Guoliang; Zhang, Tongming; Wang, Yaoyu; Egelman, Edward H.; Fan, Jun; Hsu, Victor W.; Park, Seung-Yeol; Sun, Fei
-
作者：Galperin, Michael Y.
作者单位：National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR)
-
作者：Jiang, Haowen; Tiche, Sarah Jane; He, Clifford Jiajun; Liu, Junyan; Bian, Fuyun; Jedoui, Mohamed; Forgo, Balint; Islam, Md Tauhidul; Zhao, Meng; Emengo, Pamela; He, Bo; Li, Yang; Li, Albert M.; Truong, Anh T.; Ho, Jestine; Simmermaker, Cathyrin; Yang, Yanan; Zhou, Meng-Ning; Hu, Zhen; Svensson, Katrin J.; Cuthbertson, Daniel J.; Hazard, Florette K.; Xing, Lei; Shimada, Hiroyuki; Chiu, Bill; Ye, Jiangbin
作者单位：Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; University of California System; University of California Davis; Stanford University; Agilent Technologies
摘要：Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and ...
-
作者：Robes, Jose Miguel D.; Liebergesell, Tashi C. E.; Beals, Delaney G.; Yu, Xinhui; Brazelton, William J.; Puri, Aaron W.
作者单位：United States Department of Energy (DOE); Oak Ridge National Laboratory; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
摘要：Methane is a potent greenhouse gas and a target for near-term climate change mitigation. In many natural ecosystems, methane is sequestered by microbial communities, yet little is known about how constituents of methane-oxidizing communities interact with each other and their environment. This lack of mechanistic understanding is a common issue for many important microbial communities, but it is difficult to draw links between available sequencing information and the metabolites that govern co...
