37期

最新文章

• From simplicity to complexity: A path to innovation in science and art AI翻译
  作者：Goldstein, Joseph L.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center
• Extracellular salt bridge networks around S4 implicated in HCN channel gating and heart disease AI翻译
  作者：Ryu, Kaei; Kasuya, Go; Nakajo, Koichi
  作者单位：Jichi Medical University
  摘要：The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a voltage-gated cation channel that plays a crucial role in regulating cellular excitability, especially cardiac pacemaker cells and neurons. Its dysregulation is linked to heart diseases such bradycardia and neurological disorders such as epilepsy, Parkinson's disease, and neuropathic pain. Structural and functional studies have revealed that the S4 voltage sensor the HCN channel moves downward during hyperpolarization. ...
• Giant mobility of surface- trapped ionic charges following liquid tribocharging AI翻译
  作者：Benrahla, Zouhir; Saide, Tristan; Burnaz, Louis; Verneuil, Emilie; Gravelle, Simon; Comtet, Jean
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
  摘要：The sliding motion of aqueous droplets on hydrophobic surfaces leads to charge separation at the trailing edge, with implications from triple- line friction to hydrovoltaic energy generation. Charges deposited on the solid surface have been attributed to ions or electrons ripped off from the liquid drop. However, the dynamics and exact physicochemical nature of these surface- trapped charges remains poorly explored. Here, we take advantage of a scanning- based electrostatic mapping technique, ...
• Posttranscriptional control of the B cell receptor by HuR is essential for innate B cell maintenance and function AI翻译
  作者：Capitan-Sobrino, Dunja; Mouysset, Mailys; Maloudi, Orlane; Aubert, Yann; Osma-Garcia, Ines C.; Nguyen, Trang- My M.; Dunga, Greta; Martin, Maia Nestor -; Mieulet, Virginie; Diaz-Munoz, Manuel D.
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU de Toulouse
  摘要：Innate B-1 cells constitute a self-maintained layer of defense for early detection of bacteria, clearance of apoptotic cell debris, and removal of autoantigens driving auto-immunity. B-1 cells are originated from fetal tissues, but, as opposed to B-2 cells, the molecular mechanisms behind their development and homeostatic maintenance remain largely unknown. Here, we demonstrate that posttranscriptional regulation by the RNA binding protein HuR is essential for the homeostatic self-replenishmen...
• Subtype- specific structural features of the hearing loss- associated human P2X2 receptor AI翻译
  作者：Westermann, Franka G.; Oken, Adam C.; Granith, Philip K. E.; Marimuthu, Parthiban; Mueller, Christa E.; Mansoor, Steven E.
  作者单位：University of Bonn; University of Bonn; University of Bonn; Oregon Health & Science University; Abo Akademi University; Abo Akademi University; Oregon Health & Science University
  摘要：The P2X2 receptor (P2X2R) is a slowly desensitizing adenosine triphosphate (ATP)-gated ion channel that is highly expressed in the cochlea. When mutated, the P2X2R exacerbates age-and noise-related hearing loss, but selective modulators of the receptor are lacking, and the molecular basis of activation and desensitization remains poorly understood. Here, we determine high-resolution cryoelectron microscopy structures of the full-length wild-type human P2X2R in an apo closed state and two disti...
• Cystic fibrosis: Correction of a fatal disease AI翻译
  作者：Friedman, Jeffrey M.
  作者单位：Howard Hughes Medical Institute; Rockefeller University
  摘要：The 2025 Lasker similar to DeBakey Clinical Medical Research Award has been given to Michael Welsh, Jesus (Tito) Gonzalez, and Paul Negulescu for their key roles in developing a novel treatment for cystic fibrosis (CF)-a three-drug combination that saves the lives of people with this lethal genetic disease [D. Keating etal., N. Engl. J. Med. 379, 1612-1620 (2018)]. The disease is caused by mutations that disrupt the function of a gene known as CF Transmembrane Conductance Regulator which encod...
• Convergent evolution of NFP- facilitated root nodule symbiosis AI翻译
  作者：Finegan, Christina; Kates, Heather R.; Guralnick, Robert P.; Soltis, Pamela S.; Resende Jr, Marcio F. R.; Ane, Jean-Michel; Kirst, Matias; Folk, Ryan A.; Soltis, Douglas E.
  作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Mississippi State University; State University System of Florida; University of Florida
  摘要：The origin and phylogenetic distribution of symbiotic associations between nodulating angiosperms and nitrogen- fixing bacteria have long intrigued biologists. Recent comparative evolutionary analyses have yielded alternative hypotheses: a multistep pathway of independent gains and losses of root nodule symbiosis vs. a single gain followed by numerous losses. A detailed reconstruction of the history of genes involved in signaling between nitrogen- fixing bacteria and potential hosts, particula...
• Driving the grid forward: How electric vehicle adoption shapes power system infrastructure and emissions AI翻译
  作者：Hanig, Lily; Harper, Corey D.; Nock, Destenie; Michalek, Jeremy J.
  作者单位：Carnegie Mellon University; Carnegie Mellon University; Carnegie Mellon University; Carnegie Mellon University
  摘要：We model the effect of plug-in electric vehicle (EV) adoption on U.S. power system generator capacity investment, operations, and emissions through 2050 by estimating power systems outcomes under a range of EV adoption trajectory scenarios. Our EV adoption scenarios are informed by 1) an Energy Information Administration scenario with no policy intervention, 2) EV growth expected under the Inflation Reduction Act (IRA), 3) a Biden Administration 50% EV sales target by 2030, 4) the Environmenta...
• Cooling outweighs warming across phenological transitions in the Northern Hemisphere AI翻译
  作者：Li, Yizhuo; Meng, Lin; Richardson, Andrew D.; Lee, Xuhui; Menzel, Annette; Mao, Jiafu; Diehl, Jen L.; Wang, Anzhi
  作者单位：Chinese Academy of Sciences; Shenyang Institute of Applied Ecology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Vanderbilt University; Northern Arizona University; Yale University; Technical University of Munich; Technical University of Munich; United States Department of Energy (DOE); Oak Ridge National Laboratory
  摘要：Vegetation phenology, i.e., seasonal biological events such as leaf-out and leaf-fall, regulates local climate through biophysical processes like evapotranspiration (ET) and albedo. However, the net surface temperature impact of these processes-whether ET cooling or albedo-induced warming predominates-and how the dominance changes across phenological transitions and regions remains poorly understood. Here, we investigated the effects of vegetation foliage on daytime land surface temperature (L...
• The RecBC complex protects single-stranded DNA gaps during lesion bypass AI翻译
  作者：Philippin, Gaelle; Dupaigne, Pauline; Chrabaszcz, Elodie; Iturralde, Maialen; Modesti, Mauro; Le Cam, Eric; Pages, Vincent; Laureti, Luisa
  作者单位：Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); UNICANCER; Institut Paoli-Calmette (IPC); Universite Paris Saclay; UNICANCER; Gustave Roussy; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; UNICANCER; Institut Paoli-Calmette (IPC)
  摘要：Following encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication, this ssDNA gap is filled in by one of the two lesion tolerance pathways: the error-prone Translesion Synthesis (TLS) or the error-free Homology Directed Gap Repair (HDGR). In the present work, we evidence a role for the RecBC complex distinct from its canonical function in homologous recombinati...