2025

最新文章

• Functional organization of the primary motor cortex in psychosis and the potential role of intereffector regions in psychomotor slowing AI翻译
  作者：Walther, Sebastian; Wuthrich, Florian; Pavlidou, Anastasia; Nadesalingam, Niluja; Heckers, Stephan; Nuoffer, Melanie G.; Chapellier, Victoria; Stegmayer, Katharina; Maderthaner, Lydia, V; Kyrou, Alexandra; Von Kanel, Sofie; Lefebvre, Stephanie
  作者单位：University of Bern; University Hospital of Bern; University of Wurzburg; Vanderbilt University; University of Bern; University of Bern; University Hospital of Bern; University of Zurich; University Zurich Hospital
  摘要：Altered psychomotor behavior in psychosis is poorly understood. Novel insights into the physiology of the motor cortex prompted a revision of the motor homunculus. Next to core motor effector areas, the primary motor cortex (M1) contains intereffector regions with more integrative connectivity patterns, suggestive of serving psychomotor behavior. Here, we test whether patterns of connectivity differ between patients with and without psychomotor slowing and which cortical areas are associated w...
• Skillful heat-related mortality forecasting during recent deadly European summers AI翻译
  作者：Holmberg, Emma; Quijal-Zamorano, Marcos; Ballester, Joan; Messori, Gabriele
  作者单位：Uppsala University; Centre of Natural Hazards & Disaster Science (CNDS); Uppsala University; Uppsala University; ISGlobal; Pompeu Fabra University; University of Bern; University of Bern; Stockholm University; Stockholm University
  摘要：Europe is a heatwave hotspot: numerous temperature records have been broken in recent summers, and roughly 60,000 and 50,000 heat-related deaths occurred in the summers of 2022 and 2023, respectively. With recent summers, like that of 2022, projected to become the new norm, there is a pressing need to further develop heat-health warning systems to help society adapt to a warming climate. Here, we forecast heat-related mortality by applying a statistical epidemiological framework to temperature...
• Structure of a transient protein- folding intermediate by pressure- jump NMR spectroscopy AI翻译
  作者：Masoumzadeh, Elahe; Courtney, Joseph M.; Charlier, Cyril; Ying, Jinfa; Anfinrud, Philip; Bax, Adriaan
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); University of Connecticut; Communaute d'universites et etablissements de Toulouse (Comue)
  摘要：Protein folding, as commonly portrayed, involves exploration of a rough, high- dimensional landscape, ending with a final descent into a low- energy folded state. During that journey, the protein may visit shallow basins corresponding to metastable structures, potentially of biological importance. Structural characterization of transiently populated metastable states is challenging due to their low population, which limits traditional NMR, and also makes crystallization for X- ray diffraction ...
• Supply-demand strategies for near-term climate benefits from hydrogen in the United States AI翻译
  作者：Xu, Youyi; Peng, Wei; Yao, Yuan
  作者单位：Yale University; Princeton University; Princeton University; Yale University
  摘要：Hydrogen (H-2) is a promising energy carrier for decarbonization. However, the greenhouse gas (GHG) mitigation potential of the H-2 supply and its adoption across various demand sectors in the US remains unclear. Here, we couple prospective life cycle assessment with a process-based integrated assessment model to evaluate the GHG mitigation of H-2 from supply and demand perspectives. Our results show the critical role of H-2 production mix in determining supply-side GHG mitigation potential. W...
• Augmenting rice ANNEXIN expression to counter planthopper NlAnnexin-like5 as an antivirulence strategy against a major crop pest AI翻译
  作者：Zhang, Xiao-Ya; Li, Shaoqin; Opachaloemphan, Comzit; Zhang, Chuan-Xi; He, Sheng Yang; Jiang, Yanjuan
  作者单位：Zhejiang University; Michigan State University; Yunnan University; Chinese Academy of Sciences; Xishuangbanna Tropical Botanical Garden, CAS; Duke University; Ningbo University; Howard Hughes Medical Institute; Duke University
  摘要：The brown planthopper (BPH) is the most devastating insect pest in rice, posing a serious threat to global rice production. One attractive control strategy would be based on the understanding of the virulence mechanisms of BPH at the molecular level and then designing targeted methods to neutralize such mechanisms. Salivary proteins of BPH are important players in mediating rice-BPH interactions. Here, we describe a pivotal role of a watery saliva protein, Nilaparvata lugens Annexin-like5 (NlA...
• Fiber recruitment drives a phase transition of cell polarization at a critical cell spacing in matrix-mediated tissue remodeling AI翻译
  作者：Peng, Xiangjun; Huang, Yuxuan; Kong, Wenyu; Du, Yanan; Elson, Elliot L.; Feng, Xi-Qiao; Genin, Guy M.
  作者单位：Tsinghua University; National Science Foundation (NSF); Washington University (WUSTL); Tsinghua University
  摘要：Biological tissues exhibit sharp phase transitions where cells collectively transition from disordered to ordered states at critical densities. We demonstrate through bio-chemomechanical modeling that this emergent behavior arises from a nonmonotonic depenbetween cells is optimized at intermediate stiffness values where cells can both generate sufficient forces and create strain-stiffened tension bands in the ECM. This balance establishes a critical cell spacing threshold for cell-cell communi...
• Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S- nitrosation AI翻译
  作者：Younis, Waqas; Burboa, Pia C.; Sadeghian, Tanaz; Kuzdowicz, Veronica; Cui, Chuanlong; Shu, Ping; Qin, Yong; Xie, Lai-Hua; Lillo, Mauricio A.; Beuve, Annie
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences
  摘要：We previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1), which produces cGMP, also has the ability to transfer S-nitrosothiols (SNO) to other proteins in a reaction involving oxidized Thioredoxin 1 (oTrx1). This transnitrosation cascade was established in vitro and involved Cys 610 (C610) of GC1 as the major SNO-donor. To assay the relevance of GC1 transnitrosation under physiological conditions and in oxidative pathologies, we studied a knock-in mouse in which C610 wa...
• Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons AI翻译
  作者：Rodriguez, Juan D.; Reeves, Monica N.; Chavez, Sindy R.; Wang, Hsiao- Lin V.; Chavez, Jaely Z.; Rastogi, Rhea; Sun, Liyang I.; Roberson, Mackenzie S.; Preston, Elicia A.; Massenburg, Zaynab; Cruz, Kiani N.; Chadha, Madhav S.; Hill, Emily J.; Soares, Miguel L.; Corces, Victor G.; Carpenter, Brandon S.; Schmeichel, Karen L.; Murray, John I.; Katz, David J.
  作者单位：Emory University; Emory University; University System of Georgia; Kennesaw State University; University of Pennsylvania; Pennsylvania Medicine
  摘要：How mutations in histone modifying enzymes lead to neurodevelopmental defects is unknown. To address this question, we took advantage of the invariant embryonic lineage and adult nervous system in Caenorhabditis elegans to investigate a double mutant between spr-5/Lsd1/Kdm1a (H3K4me1/2 demethylase) and met-2/Setdb1/Kmt1e (H3K9 methyltransferase). We demonstrate that spr-5; met-2 double mutant worms have a severe chemotaxis defect caused by the ectopic expression of germline genes in somatic ti...
• Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility (vol 111, E89, 2013) AI翻译
  作者：Wang, Zhongyuan; Wu, Yanping; Wang, Haifeng; Zhang, Yangqing; Mei, Lin; Fang, Xuexun; Zhang, Xudong; Zhang, Fang; Chen, Hongbo; Liu, Ying; Jiang, Yuyang; Sun, Shengnan; Zheng, Yi; Li, Na; Huang, Laiqiang
• Engineering a serum response factor superactivator of smooth muscle gene expression with a condensate-forming domain AI翻译
  作者：Gan, Peiheng; Zhou, Xinyi; Shah, Akansha M.; Bezprozvannaya, Svetlana; Chen, Kenian; Ding, Qianqian; Li, Hui; Xu, Lin; Liu, Ning; Olson, Eric N.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Differentiation of smooth muscle cells (SMCs) is driven by the activation of a set of genes controlled by serum response factor (SRF), a ubiquitous transcription factor with limited intrinsic transcriptional activity. Myocardin (MYOCD) is a strong transcriptional coactivator that orchestrates smooth muscle differentiation through its association with SRF. MYOCD forms nuclear condensates via its intrinsically disordered transcription activation domain (TAD), whereas SRF is diffusely distributed...