-
作者：Hart, William S.; Hurrell, James W.; Kaye, Alexander R.; Chand, Meera; Keeling, Matt J.; Thompson, Robin N.
作者单位：University of Oxford; Colorado State University System; Colorado State University Fort Collins; University of Warwick; University of Warwick; UK Health Security Agency (UKHSA)
摘要：In locations that do not currently experience vector-borne disease (VBD) outbreaks but may be at risk under climate change, modeling future climate suitability for transmission is important for outbreak preparedness. Uncertainty in the future climate arises from three sources-differences in emissions scenarios, structural uncertainty across climate models, and internal climate variability (ICV)-but ICV is rarely considered in climate-VBD studies. Here, we demonstrate that ICV is a key source o...
-
作者：Wijsman, Tristan; Mohd-Radzman, Nadia A.; Liu, Jieyu; Oldroyd, Giles E. D.; Kohlen, Wouter; Kulikova, Olga; Heidstra, Renze; Scheres, Ben; Franssen, Henk J.
作者单位：Wageningen University & Research; University of Cambridge; University of Cambridge
摘要：The hallmark of the legume lncRNA EARLY NODULIN40 (ENOD40), involved in rhizobium- induced nodulation, is the presence of a highly conserved stretch of 24 nucleotides, designated box2, preceded by a small open- reading- frame (sORF) coding for a peptide of 12 to 13 amino acids. Although there is a well- established link between ENOD40 and nodulation, it is not fully clear by which mechanism ENOD40 functions in this process. Here, we show that a region harboring box2 can complement nodule forma...
-
作者：Obradovich, Nick; Lawrance, Emma L.; Minor, Kelton
作者单位：Laureate Institute for Brain Research, Inc.; Massachusetts Institute of Technology (MIT); University of Tulsa; Imperial College London; Imperial College London; Columbia University; University of Copenhagen
-
作者：Amdeberhan, Tewodros; Griffin, Michael J.; Ono, Ken
作者单位：Tulane University; Vanderbilt University; University of Virginia
摘要：We revisit and elucidate the A-genus, Hirzebruch's L-genus, and Witten's W-genus, cobordism invariants of special classes of manifolds. After slight modification, involving Hecke's trick, we find that the A-genus and L-genus arise directly from Jacobi's theta function. For every k >= 0, we obtain exact formulas for the quasimodular expressions of A(k) and L-k as traces of partition Eisenstein series A(K)(tau ) = Tr-k(Phi(A):tau) and L-k(tau) = Tr-k (Phi(L):tau) which are easily converted to th...
-
作者：Barr, Keaton; He, Kevin L.; Krumbein, Andreas J.; Chanfreau, Guillaume F.
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：Splicing of terminal introns is coupled to 3 '-end processing by cleavage and polyadenylation (CPA) in mammalian genes. Whether this functional coupling is universally conserved across eukaryotes is unclear. Here, we show using long read RNA sequencing in Saccharomyces cerevisiae that splicing inactivation does not result in widespread CPA impairment, and that inactivation of CPA has limited impact on splicing efficiency. The negative impact of CPA inactivation on splicing is mainly due to tra...
-
作者：Lyu, Leke; Gill, Mandev; Stott, Guppy; Subedi, Sachin; Dailey, Cody; Veytsel, Gabriella; Alabady, Magdy; Fujimoto, Kayo; Penn, Ryker; Brown, Pamela; Sealy, Roger; Bahl, Justin
作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of Texas System; University of Texas Health Science Center Houston
摘要：A quantitative understanding of local transmission dynamics is essential for designing effective prevention strategies. In this study, we developed a computational workflow to identify viral introductions and trace locally circulating clusters. We analyzed over 26,000 SARS-CoV-2 genomes and their associated metadata, collected between January and October 2021, to explore introduction and local dispersal patterns in Greater Houston, a major metropolitan area known for its demographic diversity....
