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作者：Han, Kyung Ah; Jang, Gyubin; Lee, Hee-Yoon; Kim, Byeongchan; Kanato, Tayo; Vas, Virag; Buday, Laszlo; Liu, Xinran; Choi, Se-Young; Um, Ji Won; Ko, Jaewon
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作者：Huang, Yuqi; Luan, Shenghua; Wu, Baizhou; Li, Yugang; Wu, Junhui; Chen, Wenfeng; Hertwig, Ralph
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作者：Pisoni, Alberto; Fossataro, Carlotta; Sebastiano, Alice Rossi; Romeo, Marcella; Arrigoni, Eleonora; Lauro, Leonor Josefina Romero; Bolognini, Nadia; Garbarini, Francesca
作者单位：University of Milano-Bicocca; University of Milano-Bicocca; University of Turin; IMT School for Advanced Studies Lucca; IRCCS Istituto Auxologico Italiano
摘要：We all likely agree that tactile experience contributes to the emergence of the feeling of ownership over one's own body. Is the opposite true? We answered this question by testing whether and how the sense of body ownership gates our tactile experience. In two experiments, we exploited a well-known multisensory illusion (Rubber Hand Illusion) to induce participants to feel a fake hand as belonging to their body, while their own hand was left in a disembodiment state (illusory-phases). After e...
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作者：Wilken, Alec T.; Snipes, Chelsie C. G.; Ross, Callum F.; Luo, Zhe- Xi
作者单位：University of Chicago
摘要：The middle ear of mammals is a major functional innovation, distinctive in that it is detached from the mandible and has a tympanic membrane supported by a ring- like ectotympanic. These novelties of the middle ear have enabled modern mammals to develop more sensitive hearing than all other tetrapods, especially at higher frequencies. Fossils from recent decades have clarified the evolution of the detached middle ear from the jaw bones of Paleozoic therapsids and Mesozoic cynodonts, and the ev...
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作者：Turke, Miah J.; Raghavan, Krishna M.; Maltseva, Sofiya; Kerr, Daniel H. S.; Adams, Erin J.; Lee, Ka Yee C.
作者单位：University of Chicago; University of Chicago; University of Chicago
摘要：alpha- Synuclein is an intrinsically disordered neuronal protein that forms an amphipathic helix when it peripherally binds to lipid membranes. This membrane interaction is integral to the protein's function but is also associated with its dysfunction. Numerous membrane parameters have been identified to promote alpha- synuclein binding such as high negative charge and low lipid-packing density, which corresponds to greater lipid-packing defects- increased spacing between lipids conferred thro...
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作者：Bousdar, Nora; Perez-Ruiz, Elisabeth; Barragan, Isabel; Benitez, Jose Carlos; Rueda-Dominguez, Antonio; Oliver, Javier
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作者：Ekholm, Tobias; Shende, Vivek
作者单位：Uppsala University; Uppsala University; Royal Swedish Academy of Sciences; Mittag-Leffler Institute; University of Southern Denmark; University of California System; University of California Berkeley
摘要：Given a link in the three-sphere, its Lagrangian conormal can be transplanted to the resolved conifold, which is a certain noncompact Calabi-Yau threefold. Here we show that, as predicted by Ooguri and Vafa using string theoretic arguments, the count of all holomorphic curves in the resolved conifold ending on this Lagrangian is, appropriately understood, the collection of the HOMFLYPT invariants of all colorings of the link. This generalizes our previous work, Skeins on branes, arXiv:1901.080...
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作者：Indiveri, Giacomo
作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
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作者：Polisetty, Satya Dev; Dutta, Shuvadip; Vadnala, Rakesh Netha; Notani, Dimple; Padinhateeri, Ranjith; Sanyal, Kaustuv
作者单位：Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR); Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Department of Science & Technology (India); Bose Institute
摘要：Fungal centromeres are clustered near microtubule organizing centers to help adopt the Rabl chromosomal organization. The role of centromere clustering in driving large-scale changes in structural and functional chromatin assembly remains unclear. Here, using Hi-C and superresolution microscopy, we show that cell cycle-dependent centromere declustering and clustering states in Cryptococcus neoformans drive global changes in the 3D genome architecture. Centromeres and telomeres are scattered ar...
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作者：Roura -Martinez, David; Popa, Natalia; Jaouen, Florence; Rombaut, Cynthia; Lepolard, Catherine; Bachar, Dipankar; Borges, Ana; Cazorla, Maxime; Villet, Maxime; Moreno, Sebastien; Marie, Helene; Gascon, Eduardo
作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Assistance Publique-Hopitaux de Marseille; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Assistance Publique-Hopitaux de Marseille; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur
摘要：microRNAs (miRNAs) are key regulators of multiple biological functions. Although intensively studied, inactivating miRNAs in vivo is particularly challenging, especially in the brain. Here, we designed cell- specific tools aiming at downregulating defined miRNA species in vivo and investigating their function in discrete neuronal networks. Focusing on miR- 124, a miRNA highly expressed in the mammalian brain and transcribed from three independent chromosomal loci, we designed and validated dif...
