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作者：Jaijyan, Dabbu Kumar; Selariu, Anca; Cosme, Ruth Cruz -; Tong, Mingming; Yang, Shaomin; Stefa, Alketa; Kekich, David; Sadoshima, Junichi; Herbig, Utz; Tang, Qiyi; Church, George; Parrish, Elizabeth L.; Zhu, Hua
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作者：Lehmann, Johannes; Barrios, Edmundo; Devault, Mariana; Li, Lucinda; Nelson, Rebecca; Six, Johan; Trimmer, John
作者单位：Cornell University; Cornell University; Cornell University; Food & Agriculture Organization of the United Nations (FAO); Cornell University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Syracuse University
摘要：The circular bionutrient economy is defined here as the circular economy of nutrients in managed organic residues. Here, we posit that biochar technology can stimulate the circular bionutrient economy by meeting the following three requirements: 1) nutrients are captured in a dry form, increasing market value and lowering transportation cost; 2) individual nutrients can be captured separately and combined as needed for particular plants and soils; 3) all pathogens and most pollutants can be re...
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作者：Lewanski, Alexander L.; Linderoth, Tyler; Thompson, Greg; Tringali, Angela; Angell, Emily; Bowman, Reed; Fitzpatrick, Sarah W.
作者单位：Michigan State University; Michigan State University; Michigan State University
摘要：Anthropogenic destruction and fragmentation of habitat restrict many species to small, isolated populations, which often experience high extirpation risk. Restoring connectivity through translocations is one approach for mitigating the demographic and genetic perils faced by small populations. However, translocation interventions often lack substantial postrelease monitoring, and thus important information including the performance of translocated individuals, the long- term impacts on the rec...
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作者：Massatti, Rob; Faske, Trevor M.; Barnes, Ivana M.; Leger, Elizabeth A.; Parchman, Thomas L.; Richardson, Bryce A.; Knowles, L. Lacey
作者单位：United States Department of the Interior; United States Geological Survey; University of Michigan System; University of Michigan; Nevada System of Higher Education (NSHE); University of Nevada Reno; United States Department of Agriculture (USDA); United States Forest Service
摘要：Many widespread plant taxa of western North America have diversified into phenotypically and genetically divergent lineages due to complex biogeographic histories across heterogeneous landscapes. Mosaic hybrid zones can form when geographically co-occurring, yet environmentally distinct, lineages cross-pollinate and form hybrids that occupy unique environmental niches absent of a geographic cline. This expands the total environmental space across which parental and hybrid individuals grow, res...
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作者：Naidoo, Robin; Aylward, Cody; Elliott, Wendy; Keeley, Annika; Kinnaird, Margaret; Knight, Michael; Papp, Cristian- Remus; Thapa, Kanchan; Antelo, Rafael
作者单位：World Wildlife Fund; University of British Columbia; Nelson Mandela University; Babes Bolyai University from Cluj
摘要：Implementing ecological connectivity conservation in large landscapes requires cutting- edge science combined with consideration of ecological, socioeconomic, and cultural factors that collectively shape the outcomes of conservation efforts. We outline a theory of change (ToC) for connectivity conservation to improve the ecological condition of landscapes and biodiversity and the ecosystem services upon which humans depend. We review connectivity conservation efforts on four continents in larg...
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作者：Hsu, Cheng Chih; Chamblee, Michelle; Ye, Chengjin; Shamseldin, Mohamed M.; Yoo, Sung J.; Li, Pei; Zhang, Yuexiu; Liu, Yajie; Hall, Jesse M.; Xu, Jiayu; Miao, Hanson; Thongpan, Ilada; Mahesh, K. C.; Liang, Xueya; Yount, Jacob S.; Peeples, Mark E.; Boyaka, Prosper N.; Dubey, Purnima; Martinez-Sobrido, Luis; Liu, Shan-Lu; Li, Jianrong
作者单位：University System of Ohio; Ohio State University; Texas Biomedical Research Institute; University System of Ohio; Ohio State University; Egyptian Knowledge Bank (EKB); Capital University - Egypt; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
摘要：The emergence of immune-evasive SARS-CoV-2 Omicron subvariants highlights the need to develop a mucosal SARS-CoV-2 vaccine that can provide broad protection against virus infection and transmission. Here, we developed an intranasal monovalent SARS-CoV-2 vaccine expressing the six-proline-stabilized prefusion spike proteins (preS-6P) of Omicron XBB.1.5 based on the attenuated mumps virus (MuV) Jeryl Lynn (JL1) vaccine strain. We also developed an intranasal trivalent vaccine expressing the preS...
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作者：Feng, Xiang; Schut, Gerrit J.; Putumbaka, Saisuki; Li, Huilin; Adams, Michael W. W.
作者单位：Van Andel Institute; University System of Georgia; University of Georgia; California Institute of Technology
摘要：Members of the tungsten-containing oxidoreductase (WOR) family, which contain a tungstopyranopterin (Tuco) cofactor, are typically either monomeric (WorL) or heterodimeric (WorLS). These enzymes oxidize aldehydes to the corresponding acids while reducing the redox protein ferredoxin. They have been structurally characterized mainly using WORs from hyperthermophilic archaea. The WORs of some bacteria contain three additional subunits of the BfuABC family and these chimeric WorABCSL enzymes cata...
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作者：Gao, Forson; Ye, Fuzhou; Jovanovic, Milija; Buck, Martin; Zhang, Xiaodong
作者单位：Imperial College London; Imperial College London; University of Belgrade; Francis Crick Institute
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作者：Halford, Julia; Senatore, Amanda J.; Berryman, Sage; Semidey, Destinee; Munoz, Antonio; Doan, Ryan A.; Coombs, Adam M.; Noimany, Brandon; Emberley, Katie; Emery, Ben; Monk, Kelly R.; Murthy, Swetha E.
作者单位：Oregon Health & Science University; Oregon Health & Science University
摘要：Infantile hypomyelinating leukodystrophy 19 (HLD19) is a rare genetic disorder where patients exhibit reduced myelin in central nervous system (CNS) white matter tracts and present with varied neurological symptoms. The causative gene TMEM63A encodes a mechanosensitive ion channel whose role in myelination is largely unexplored. Our study shows that TMEM63A is a major regulator of oligodendrocyte (OL)-dependent myelination in the CNS. In mouse and zebrafish, Tmem63a inactivation led to early d...
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作者：Potapov, Peter; Tyukavina, Alexandra; Turubanova, Svetlana; Hansen, Matthew C.; Giglio, Louis; Hernandez-Serna, Andres; Lima, Andre; Harris, Nancy; Stolle, Fred
作者单位：University System of Maryland; University of Maryland College Park
摘要：Global forests provide key ecosystem services, from climate regulation to biodiversity habitat, but are under increasing pressure from the combined impacts of climate and land use change. Here, we show that forest disturbance due to fire is growing globally, with the most dramatic increases in intact forest landscapes, highlighting an existential threat to remaining high biomass, high biodiversity forests. The global annual area of forest disturbance due to fire for 2023 and 2024 was highest s...
