2025

最新文章

• Cultural innovation can increase and maintain biodiversity: A case study from medieval Europe AI翻译
  作者：Spitzig, Adam; Rosch, Manfred; Woodbridge, Jessie; Bauch, Martin; Guzowski, Piotr; Erhart, Peter; Fyfe, Ralph; Marinova, Elena; Izdebski, Adam
  作者单位：Stanford University; Harvard University; Ruprecht Karls University Heidelberg; University of Plymouth; University of Bialystok; Nicolaus Copernicus University; Max Planck Society; University of Warsaw; Research Institute for Humanity & Nature (RIHN)
  摘要：Numerous research efforts have used paleoecological data to reconstruct past biodiversity in Europe. In these projects, researchers have identified increases in biodiversity over the Holocene and hinted at a positive correlation with human population. These are important findings but are not easily translated into effective biodiversity conservation and restoration policy. We argue that, in order to better inform policymaking, studies of past biodiversity dynamics should include analyses of co...
• Joubert syndrome 26 protein enforces compartmentalized motility of a ciliary kinesin AI翻译
  作者：Wang, Shimin; Li, Ming; Chen, Guanghan; Chen, Zhe; Lei, Kexin; Okten, Zeynep; Xie, Shanshan; Zhou, Tianhua; Li, Wei; Ou, Guangshuo
  作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Technical University of Munich; Zhejiang University; Zhejiang University; Tsinghua University
  摘要：Cilia are essential cellular antennae that rely on precise motor- driven transport to assemelegans-cooperate to transport cargo along cilia, with kinesin- II operating in the middle segment and OSM- 3 taking over distally. However, how kinesin- II is spatially confined to prevent its invasion into distal regions remains unclear. Here, we identify JBTS- 26 localizes to axonemal doublet microtubules in the ciliary middle segment, distal transport. Loss of JBTS- 26 allows kinesin- II to invade th...
• A chromatin- linked CPL2-PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing AI翻译
  作者：Zhang, Lingrui; Tang, Kai; Long, Tiandan; Zhang, Li-Li; Zhu, Peipei; Fan, Fuhua; Fu, Jianxin; Zhang, Chao; Zhu, Jian-Kang
  作者单位：Purdue University System; Purdue University; Sichuan Agricultural University; Purdue University System; Purdue University; Guizhou University; Zhejiang A&F University; Southern University of Science & Technology; Southern University of Science & Technology
  摘要：While multiple chromatin-based epigenetic pathways are well characterized, their genome-wide coordination and hierarchical interplay remain poorly understood. We previously identified the BAH-PHD-CPL2 complex, where AIPP3 binds H3K27me3 via its BAH domain and, in concert with PHD2 and PHD3 (PHD2/3), recruits CPL2 to repress transcription by dephosphorylating RNA Polymerase II. Here, we show that CPL2 and PHD2/3 form a distinct module (CPL2-PHD2/3) that safeguards CHH DNA methylation and silenc...
• Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche AI翻译
  作者：Lang, Annemarie; Collins, Joseph M.; Nijsure, Madhura P.; Belali, Simin; Khan, Mohd Parvez; Moharrer, Yasaman; Schipani, Ernestina; Yien, Yvette Y.; Fan, Yi; Gelinsky, Michael; Vinogradov, Sergei A.; Koch, Cameron; Boerckel, Joel D.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Technische Universitat Dresden; Carl Gustav Carus University Hospital; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Pennsylvania
  摘要：Oxygen tension dynamically regulates stem cell fate and tissue regeneration, yet how local oxygen availability is controlled within the bone marrow niche remains poorly understood. While bone marrow injury, such as by bone fracture, disrupts marrow vasculature, the consequences for local oxygen tension remain unclear. Here, we show in mice that while the tissue oxygen tension in bone marrow is low (25 mmHg, similar to 4% O-2), intracellular oxygenation is heterogeneous, and erythroid cells are...
• A binary- distributed effector modulates fungal host preference for drosophilids by targeting a lineage- specific immune factor AI翻译
  作者：Luo, Yujuan; Sheng, Xinlu; Wei, Dongxiang; Song, Shuangxiu; Chen, Chen; Wu, Hongyun; Shang, Junmei; Wang, Chengshu
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; ShanghaiTech University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Unlike host-specific parasites, broad-spectrum pathogens often exhibit an enigmatic strain/race-level preference for infecting particular host species over others. Here, we identify a polymorphic effector (termed Bhe1) that exhibits a binary presence-absence distribution pattern among strains of the entomopathogenic fungus Beauveria bassiana. Gene deletion and overexpression in Bhe1-present strains revealed that this gene functions as a virulence factor against Drosophila species but dispensab...
• MC1R determines healing outcomes in acute and chronic cutaneous wounds AI翻译
  作者：Nawilaijaroen, Yonlada; Rocliffe, Holly R.; Austin-Williams, Shani; Krilis, Georgios; Dawson, Charlotte; Harijanto, Pruistinne; Pellicoro, Antonella; Zhou, Kanheng; Ji, Yubo; Bain, Connor A.; Kilpatrick, Alastair M.; Chen, Yuhang; Biswas, Asok; Forbes, Shareen; Crichton, Michael; Huang, Zhihong; Forbes, Stuart J.; Caporali, Andrea; Cash, Jenna L.
  作者单位：University of Edinburgh; University of London; Queen Mary University London; University of Edinburgh; University of Dundee; Heriot Watt University; University of Edinburgh; University of Edinburgh
  摘要：Chronic wounds (CWs) represent a major clinical challenge, characterized by persistent inflammation and failed repair. While proresolving pathways are known to regulate inflammatory responses, their potential dysfunction in CWs remains unexplored. Here, we identify dysregulation of the pro-opiomelanocortin-melanocortin 1 receptor (POMC-MC1R) axis as a common feature across pressure ulcers, venous ulcers, and diabetic ulcers. Using MC1Re/e mice lacking functional MC1R, we demonstrate impaired w...
• A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner (vol 121, e2319641121, 2024) AI翻译
  作者：Rigney, Nicole; Campos-Lira, Elba; Kirchner, Matthew K.; Wei, Wei; Belkasim, Selma; Beaumont, Rachael; Singh, Sumeet; Suarez, Sara Guedez; Hartswick, Delenn; Stern, Javier E.; de Vries, Geert J.; Petrulis, Aras
• Electrokinetic nanoparticle transport in an interconnected porous environment: Decoupling cavity escape and directional bias AI翻译
  作者：Shi, Anni; Mirfendereski, Siamak; Gupta, Ankur; Schwartz, Daniel K.
  作者单位：University of Colorado System; University of Colorado Boulder
  摘要：Electrokinetic transport of nanoparticles in porous media is crucial for separation technologies, but the boundary-field coupling effects in three-dimensional (3D) interconnected porous spaces remain challenging to understand. Using superresolution 3D tracking of nanoparticles in interconnected cavities, we observed an unexpected disconnect between cavity escape time and directional bias as a function of electric field strength. The cavity escape times of individual nanoparticles decreased dra...
• How culturally wise psychological interventions can help reduce poverty AI翻译
  作者：Thomas, Catherine C.; Premand, Patrick; Bossuroy, Thomas; Sambo, Soumaila Abdoulaye; Markus, Hazel Rose; Walton, Gregory M.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Stanford University; The World Bank; The World Bank
  摘要：Poverty is characterized by multidimensional economic, social, and psychological constraints that undermine people's agency to pursue new opportunities and shape their life outcomes. How can interventions best support the agency of low-income individuals and, in so doing, boost poverty-reduction efforts? We theorize and find that agency interventions are effective when designed to be culturally wise, i.e., attuned to the model of agency predominant in a cultural context. Focusing on low-income...
• The synergy of methylphenidate-and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction AI翻译
  作者：Ceceli, Ahmet O.; King, Sarah G.; Drury, K. Rachel; McClain, Natalie; Gray, John; Dassanayake, Priyanthi S.; Newcorn, Jeffrey H.; Schiller, Daniela; Alia-Klein, Nelly; Goldstein, Rita Z.
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：Drug-related memories can hinder abstinence goals in drug addiction. Promoting nondrugmemories via ventromedial prefrontal cortex (vmPFC)-and amygdala-guided extinctionyields mixed success. Postretrieval extinction (RE) destabilizes and updates memoriesduring reconsolidation, improving extinction. Supplementing RE, we tested methylphenidate(MPH), a dopamine agonist that promotes PFC-dependent learning and memory in cocaineuse disorder (CUD). In a proof-of-concept double-blind randomized clinic...