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作者：Pokorzynski, Nick D.; Jones, Katarina A.; Campagna, Shawn R.; Groisman, Eduardo A.
作者单位：Yale University; University of Tennessee System; University of Tennessee Knoxville
摘要：Glucose is the preferred carbon source of most studied microorganisms. However, we now report that glucose loses preferred status when the intracellular pathogen Salmonella enterica serovar Typhimurium experiences cytoplasmic magnesium (Mg2+) starvation. We establish that this infection-relevant stress drastically reduces synthesis of cyclic adenosine monophosphate (cAMP), the allosteric activator of the cAMP receptor protein (CRP), master regulator of carbon utilization. The resulting reducti...
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作者：Rodero, Cristobal; Niederer, Steven A.
作者单位：Imperial College London; Alan Turing Institute
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作者：Hall, Johanna L.; Yang, Shiun -, Jr.; Limmer, David T.; Fleming, Graham R.; Rossky, Peter J.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Massachusetts Institute of Technology (MIT)
摘要：Photosystem II (PSII) can achieve near-unity quantum efficiency of light harvesting in ideal conditions and can dissipate excess light energy as heat to prevent the formation of reactive oxygen species (ROS) under light stress. Understanding how this pigment-protein complex accomplishes these opposing goals is a topic of great interest that has so far been explored primarily through the lens of the system energetics. Despite PSII's known flat energy landscape, a thorough consideration of the e...
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作者：Lin, Leiming; Li, Zheng; Ren, Jun; Meng, Ying; Luan, Fubo
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; North University of China
摘要：The co-occurrence of arsenic and uranium in groundwater has been found in many countries, posing a significant challenge to human health. Here, we have demonstrated the efficient simultaneous removal of arsenic and uranyl-carbonate complexes from groundwater using {001}-TiO2. Surprisingly, the presence of U(VI) greatly enhanced the adsorption of As(V) on {001}-TiO2, while As(V) had a negligible impact on U(VI) adsorption. Through in situ ATR-FTIR spectroscopy, we uncovered a mechanism involvin...
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作者：Wu, Mengjie; Wu, Xinda; Lopez, Alfonso; Blanchfield, Paul J.; Ren, Hongqiang; Zhong, Huan
作者单位：Nanjing University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC)
摘要：Climate change is intricately influencing the accumulation of neurotoxic methylmercury (MeHg) in human food webs, potentially leading to uneven exposure risks across regions. Here, we reveal that climate change will elevate MeHg risks in China, with implications for regional inequalities in Asia through a climate- mercury- food- health nexus. Using a compiled fish mercury dataset from 13,000 samples and machine learning, we find that freshwater wild fish-an essential component of the Asian die...
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作者：Chen, Gang; Han, Qingxia; Li, Wan-Xiang; Hai, Rong; Ding, Shou-Wei
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作者：Yan, Yan; Zhu, Jiaping; Qiu, Qi; Li, Jigang; Cao, Xiaofeng; Deng, Xian
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; China Agricultural University
摘要：The plant photoreceptor phytochrome B (phyB) mediates the responses of plants to red (R) light. Trimethylation of histone H3 at Lys27 (H3K27me3) plays a crucial role in governing gene expression and controlling the response of plants to environmental changes. However, how dynamic H3K27me3 mediates plant response to R light is poorly understood. Here, we report that RELATIVE OF EARLY FLOWERING 6 (REF6), an H3K27me3 demethylase, promotes hypocotyl elongation under R light in Arabidopsis. Upon ex...
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作者：Lecker, Maya; Hallock, Scott; Danielson, Axel; Van Aertrickc, Maximilien; Kindt, Merel; Aviezer, Hillel
作者单位：Hebrew University of Jerusalem; University of Amsterdam
摘要：Central emotion theories assume that during threatening and dangerous events the human face signals a prototypical, distinct, and universally recognized expression of fear which can be accurately decoded by conspecific perceivers. Due to the importance of fear expressions, an unusually large body of research has been dedicated to exploring their evolutionary origins, neurobiological mechanisms, and clinical significance. However, these studies typically utilize highly recognizable posed actor ...
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作者：Bednarek, Angela T.; Miyamoto, Ben
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作者：Clark, David G.; Beiran, Manuel
作者单位：Columbia University; Columbia University
摘要：Neural circuits comprise multiple interconnected regions, each with complex dynamics. The interplay between local and global activity is thought to underlie computational flexibility, yet the structure of multiregion neural activity and its origins in synaptic connectivity remain poorly understood. We investigate recurrent neural networks with multiple regions, each containing neurons with random and structured connections. Inspired by experimental evidence of communication subspaces, we use l...
