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作者：Wang, Shuangshuang; Ye, Hanghang; Yang, Congfan; Zhang, Yan; Pu, Jiawen; Ren, Yuhan; Xie, Kun; Wang, Lingxiao; Zeng, Dechao; He, Haoqiang; Ji, Haoyan; Herrera-Estrella, Luis Rafael; Xu, Guohua; Chen, Aiqun
作者单位：Nanjing Agricultural University; Texas Tech University System; Texas Tech University; Instituto Politecnico Nacional - Mexico; CINVESTAV - Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional; Nanjing Agricultural University
摘要：Nitrogen (N) is the most important essential nutrient required by plants. Most land plants have evolved two N uptake pathways, a direct root pathway and a symbiotic pathway, via association with arbuscular mycorrhizal (AM) fungi. However, the interaction between the two pathways is ambiguous. Here, we report that OsNAR2.1-OsNRT2s, the nitrate (NO3-) transporter complexes with crucial roles in direct NO3 - uptake, are also recruited for symbiotic NO3- uptake. OsNAR2.1 and OsNRT2.1/2.2 are coreg...
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作者：Gerace, Skylar D.; Yu, Jun; Moore, J. Keith; Martiny, Adam C.
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine
摘要：Climate warming is increasing ocean stratification, which in turn should decrease the nutrient flux to the upper ocean. This may slow marine primary productivity, causing cascading effects throughout food webs. However, observing changes in upper ocean nutrients is challenging because surface concentrations are often below detection limits. We show that the nutricline depth, where nutrient concentrations reach well- detected levels, is tied to productivity and upper ocean nutrient availability...
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作者：Lamers, Jasper; Zhang, Yanxia; van Zelm, Eva; Leong, Cheuk Ka; Meyer, A. Jessica; de Zeeuw, Thijs; Verstappen, Francel; Veen, Mark; Deolu-Ajayi, Ayodeji O.; Gommers, Charlotte M. M.; Testerink, Christa
作者单位：Wageningen University & Research; Wageningen University & Research; South China Agricultural University; Utrecht University; Wageningen University & Research
摘要：Soil salinity presents a dual challenge for plants, involving both osmotic and ionic stress. In response, plants deploy distinct yet interconnected mechanisms to cope with these facets of salinity stress. In this investigation, we observed a substantial overlap in the salt (NaCl)- induced transcriptional responses of Arabidopsis roots with those triggered by osmotic stress or the plant stress hormone abscisic acid (ABA), as anticipated. Notably, a specific cluster of genes responded uniquely t...
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作者：Winans, James B.; Zeng, Lanying; Nadell, Carey D.
作者单位：Dartmouth College; Dartmouth College; Texas A&M University System; Texas A&M University College Station
摘要：Bacteria form groups composed of cells and a secreted polymeric matrix that controls their spatial organization. These groups-termed biofilms-can act as refuges from environmental disturbances and from biotic threats, including phages. Despite the ubiquity of temperate phages and bacterial biofilms, live propagation of temperate phages within biofilms has not been characterized on cellular spatial scales. Here, we leverage several approaches to track temperate phages and distinguish between ly...
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作者：Bagnoli, Enrico; Lin, Yu- En; Burel, Sophie; Jaimon, Ebsy; Antico, Odetta; Themistokleous, Christos; Nikoloff, Jonas M.; Squires, Samuel; Morella, Ilaria; Watzlawik, Jens O.; Fiesel, Fabienne C.; Springer, Wolfdieter; Tonelli, Francesca; Lis, Pawel; Brooks, Simon P.; Dunnett, Stephen B.; Brambilla, Riccardo; Alessi, Dario R.; Pfeffer, Suzanne R.; Muqit, Miratul M. K.
作者单位：University of Dundee; Stanford Medicine; Stanford University; University of Pavia; Cardiff University; Mayo Clinic; Mayo Clinic; Cardiff University
摘要：Mutations in Leucine- rich repeat kinase 2 (LRRK2) and PTEN- induced kinase 1 (PINK1) are associated with familial Parkinson's disease (PD). LRRK2 phosphorylates Rab guanosine triphosphatase (GTPases) within the Switch II domain while PINK1 directly phosphorylates Parkin and ubiquitin (Ub) and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we have crossed LRRK2 [R1441C] mutant knock- in mice with PINK1 knock- out (KO) mice and report that loss of PINK1 does not impact en...
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作者：Chae, Rebecca L.; Siddiqui, Rafay; Xu, Yan
作者单位：Santa Clara University; Virginia Polytechnic Institute & State University
摘要：The urgent calls for action on climate change underscore the importance of increasing sustainable behavior among individuals who have traditionally veered away from it, such as those on the political right. Utilizing data from four geopolitical regions across 24 countries, we explore whether vulnerability to natural disasters, brought on by either experiencing or anticipating a natural disaster, is a crucial factor. We find that as vulnerability to natural disasters increases, sustainable cons...
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作者：Jin, Guang-Bo; Rong, Shao-Qin; Yin, Dong-Rui; Deng, Zhou-Hao; Ding, Xiao; Sheng, Meng-Yao; Gao, Hai; Kohli, Rahul M.; Xu, Guo-Liang; Zhou, Dan
作者单位：Fudan University; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Fudan University
摘要：Ten- eleven translocation (TET) enzymes oxidize 5- methylcytosine (mC) in DNA, contributing to the regulation of gene transcription. Diverse mutations of TET2 are frequently found in various blood cancers, yet the full scope of their functional consequences has been unexplored. Here, we report that a subset of TET2 mutations identified in leukemia patients alter the substrate specificity of TET2 from acting on mC to thymine. This neomorphic activity results from substitutions at key residues i...
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作者：Xu, Yue; Gong, Fanglin; Golubovic, Alex; Strilchuk, Amy; Chen, Jingan; Zhou, Muye; Dong, Songtao; Seto, Breanna; Li, Bowen
作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre
摘要：The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthe-sized through complex, multistep chemical processes that are both time- consuming and require significant engineering. Furthermore, the development of new ionizable lipids is hindered by a limited understanding of the structure- activity relationships essential for effective mRNA delivery. In this work, we have developed...
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作者：Boomsma, Jacobus J.
作者单位：University of Copenhagen
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作者：Kaye, Thomas G.; Bak, Judyta; Marcelo, Henry William; Pittman, Michael
作者单位：Jagiellonian University; Chinese University of Hong Kong; University of London; University College London
摘要：Tattoos were a prevalent art form in pre- Hispanic South America exemplified by mummified human remains with preserved skin decoration that reflects the personal and cultural representations of their times. Tattoos are known to fade and bleed over time and this is compounded in mummies by the decay of the body, inhibiting the ability to examine the original art. Laser- stimulated fluorescence (LSF) produces images based on fluorescence emitted from within the target. Here, we present the first...
