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作者：Weeks, Amy M.
作者单位：University of Wisconsin System; University of Wisconsin Madison
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作者：Ambrogi, Marcela; Hernandez, Laura L.; Strand, Douglas W.; Kumar, Sathish; Romero, Michael F.; Barasch, Jonathan; Ridlon, Monica; Stietz, Kimberly P. Keil; Vezina, Chad M.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Texas System; University of Texas Southwestern Medical Center; Mayo Clinic; Columbia University
摘要：The urethra is considered a passive conduit for urine. Here, we reveal a surprising multicellular signaling pathway guiding the urethra's dynamic response to an invading pathogen. Using a genetic approach in female mice, we deposited uropathogenic Escherichia coli into the distal urethra to establish a model of ascending urinary tract infection that progresses to the bladder within 4 h. We show that urethral neuroendocrine cells (UNECs), and the serotonin they synthesize, protect the bladder f...
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作者：Sun, Shufeng; Liang, Biqing; Koplas, Adam; Tikhonenko, Irina; Nachury, Maxence; Khodjakov, Alexey; Sui, Haixin
作者单位：Wadsworth Center; State University of New York (SUNY) System; State University of New York (SUNY) System; University at Albany, SUNY; University of California System; University of California San Francisco
摘要：Structural homeostasis and proper distributions of signaling molecules in cilia require a constant flow of cargoes carried by intraflagellar transport (IFT) trains in both anterograde and retrograde directions within the thin, long ciliary shafts. In the motile cilium framework, the nine microtubule doublets of the same length serve as the transportation rails, and a preferential association to the two subtubules of the microtubule doublets prevents collisions among the IFT trains that move in...
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作者：Tworak, Aleksander; Smidak, Roman; Menezes, Carolline Rodrigues; Du, Samuel W.; Suh, Susie; Choi, Elliot H.; Imanishi, Sanae S.; Dong, Zhiqian; Lewandowski, Dominik; Fong, Kristen E.; Grigorean, Gabriela; Pinto, Antonio F. M.; Xu, Qianlan; Skowronska-Krawczyk, Dorota; Blackshaw, Seth; Imanishi, Yoshikazu; Palczewski, Krzysztof
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of California System; University of California Davis; Salk Institute; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine
摘要：Membrane frizzled-related protein (MFRP), present in the retinal pigment epithelium (RPE), is an integral membrane protein essential for ocular development and the normal physiology of the retina. Mutations in MFRP are associated with autosomal recessive nonsyndromic nanophthalmos, leading to severe hyperopia and early-onset retinitis pigmentosa. While several preclinical gene-augmentation and gene-editing trials hold promise for future therapies aimed at stopping degeneration and restoring re...
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作者：Xiong, Rui; Hu, Yinyin; Wang, Menghan; Han, Ting; Hu, Yuying; Ma, Chaolin; Li, Baoming
作者单位：Nanchang University; Nanchang University; Hangzhou Normal University
摘要：Maternal separation (MS), a chronic stress event in early life, impairs myelination in the prefrontal cortex (PFC) and leads to PFC cognitive disorders. It remains largely unclear how such deficits are mediated. Here, we show that peripheral CD4+ T cells play an essential role in mediating the destructive effects of MS on medial prefrontal cortical (mPFC) myelination and cognitive functions in mice. Offspring mice with MS experience (MS mice) exhibited an increase in CD4+ T cells and xanthine ...
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作者：Li, Ming; Chen, Zhe; Guo, Zhengyang; Wang, Yang; Chai, Yongping; Li, Wei; Ou, Guangshuo
作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University
摘要：The tubulin tail is a key element for microtubule (MT) functionality, but the functional redundancy of tubulin genes complicates the genetic determination of their physiological functions. Here, we removed the C-terminal tail of five alpha-and four beta-tubulin genes in the C. elegans genome. Sensory cilia typically exhibit an axoneme that longitudinally differentiates into a middle segment with doublet MTs and a distal segment with singlet MTs. However, the excision of the alpha-tubulin tail,...
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作者：Cheryan, Sapna; Muragishi, Gregg A.
作者单位：University of Washington; University of Washington Seattle
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作者：Tang, Qi; Ichikawa, Yuji; Hassani, Mostafa
作者单位：Cornell University; Tohoku University; Cornell University
摘要：Supersonic impact of metallic microparticles onto metallic substrates generates extreme interfacial deformation and high contact pressures, enabling solid-state metallic bonding. Although higher impact velocities are generally believed to improve bond quality and mechanical properties in materials formed by supersonic impact deposition, here we report a peak in bond strength for single microparticle impact bonding, followed by a decline at higher impact velocities. Our in situ micromechanical ...
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作者：Wang, Zhaofeng; Wu, Xianshuo; Zhang, Siyuan; Yang, Shuyuan; Gao, Pichao; Huang, Panhui; Xiao, Yanling; Shen, Xianfeng; Yao, Ximeng; Zeng, Dong; Jie, Jiansheng; Zhou, Yecheng; Yang, Fangxu; Li, Rongjin; Hu, Wenping
作者单位：Tianjin University; Tianjin University; Tianjin University; Nankai University; Collaborative Innovation Center of Chemical Science & Engineering Tianjin; Soochow University - China; Sun Yat Sen University
摘要：Organic semiconductors (OSCs) are pivotal for next-generation flexible electronics but are limited by an intrinsic trade-off between mobility and stability. We introduce adaptive surface doping (ASD), an innovative strategy to overcome this dichotomy in OSCs. ASD's adaptive mechanism accommodates a broad range of dopant concentrations, optimally passivating trap states as needed. This approach significantly lowers the trap energy level from 84 meV to 14 meV above the valence band edge, promoti...
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作者：Mrnjavac, Natalia; Martin, William F.
作者单位：Heinrich Heine University Dusseldorf
