2025

最新文章

• Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan AI翻译
  作者：Pradhan, Arnab; Nev, Olga A.; Leaves, Ian; Nev, Oleg A.; Ma, Qinxi; Milne, Gillian; Patterson, Grace; Netea, Mihai G.; Erwig, Lars P.; Farrer, Rhys A.; Brown, Gordon D.; van den Berg, Hugo A.; Gow, Neil A. R.; Brown, Alistair J. P.
  作者单位：UK Research & Innovation (UKRI); University of Exeter; Medical Research Council UK (MRC); University of Aberdeen; University of Exeter; Radboud University Nijmegen; Radboud University Nijmegen; University of Bonn; Cancer Research UK; University of Warwick
  摘要：Fungal pathogens infect billions and kill millions of people each year. Many of these pathogens have evolved strategies to evade our antifungal immune defenses. Candida albicans, for example, masks the proinflammatory pathogen-associated molecular pattern (PAMP) beta-1,3-glucan, in response to specific host signals such as lactate. In C. albicans, most beta-1,3-glucan lies in the inner cell wall shielded, by the outer mannan layer, from recognition by certain immune cells such as macrophages. ...
• Generative prediction of causal gene sets responsible for complex traits AI翻译
  作者：Kuznets-Speck, Benjamin; Ogonor, Buduka K.; Wytock, Thomas P.; Motter, Adilson E.
  作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University
  摘要：The relationship between genotype and phenotype remains an outstanding question for organism-level traits because these traits are generally complex. The challenge arises from complex traits being determined by a combination of multiple genes (or loci), which leads to an explosion of possible genotype-phenotype mappings. The primary techniques to resolve these mappings are genome/transcriptome-wide association studies, which are limited by their lack of causal inference and statistical power. ...
• Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography AI翻译
  作者：Gonzalez-Magaldi, Monica; Gullapalli, Anuradha; Papoulas, Ophelia; Liu, Chang; Leung, Adelaide Y. -H.; Guo, Luqiang; Brilot, Axel F.; Marcotte, Edward M.; Ke, Zunlong; Leahy, Daniel J.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：We report here transport of full-length epidermal growth factor receptor (EGFR), Insulin Receptor, 7-pass transmembrane receptor Smoothened, and 13-pass Sodium-iodide symporter to extracellular vesicles (EVs) for structural and functional studies. Mass spectrometry confirmed the transported proteins are the most abundant in EV membranes, and the presence of many receptor-interacting proteins in EVs demonstrates their utility for characterizing membrane protein interactomes. Cryo-electron tomog...
• Stability of general cognitive ability from infancy to adulthood: A combined twin and genomic investigation AI翻译
  作者：Gustavson, Daniel E.; Borriello, Giulia A.; Karhadkar, Mohini A.; Rhee, Soo Hyun; Corley, Robin P.; Rhea, Sally-Ann; DiLalla, Lisabeth F.; Wadsworth, Sally J.; Friedman, Naomi P.; Reynolds, Chandra A.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University System of Ohio; Kent State University; Kent State University Kent; Kent State University Salem; Southern Illinois University System; Southern Illinois University
  摘要：Measures of general cognitive ability (GCA) are highly stable from adolescence onward, particularly at the level of genetic influences. In contrast, measurement of GCA in early life (before 3 y old) is less reliable and less is known about the stability of GCA across this period, including its relation to adult GCA. Using data from the Colorado Longitudinal Twin study (N = 1,098), we examined the stability of GCA measures across 5 time-points (years 1 to 2, 3, 7, 16, and 29), including how an ...
• Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening AI翻译
  作者：Juna, Dong-Jae; Schumacher, Marc M.; Joa, Youngah; Faulkner, Rebecca A.; Yang, Yangyang; Tsien, Jet; Qin, Tian; DeBose-Boyd, Russell A.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Dallas Baptist University
  摘要：Schnyder corneal dystrophy (SCD) is a rare autosomal dominant condition characterized by the opacification of the cornea owing to the abnormal deposition of cholesterol. SCD-associated mutations have been identified in the gene encoding UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4 (MK-4). Beyond its enzymatic role, UBIAD1 serves as a key regulator of the endoplasmic reticulum (ER)-...
• UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia AI翻译
  作者：Pacella, Gina N.; Kuprasertkul, Nina; Bao, Lydia; Huang, Sijia; D'souza, Carina; Prouty, Stephen M.; Anderson, Amy; Lopez, Alexandra M. Maldonado; Sinkfield, Morgan; Olingou, Cyria; Seykora, John T.; Capell, Brian C.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine
  摘要：The X-linked histone demethylase, UTX (KDM6A), is a master regulator of gene enhancers, though its role in self-renewing epithelia like the skin is not well understood. Here, we find that UTX is a key regulator of skin differentiation via the regulation of retinoic acid (RA) signaling, an essential metabolic pathway in both skin homeostasis, as well as in the treatment of an array of skin conditions ranging from cancer and acne to aging. Through deletion of Utx in the skin, we demonstrate dire...
• Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability AI翻译
  作者：Wang, Jun; Liao, Long; Yang, Bo; Miao, Beiping; Bernards, Rene; Qin, Wenxin; Sun, Chong; Wang, Cun
  作者单位：Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Helmholtz Association; German Cancer Research Center (DKFZ); Netherlands Cancer Institute
• Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility AI翻译
  作者：Brill, Julia; Clarke, Blaise; Hong, Ingie; Huganir, Richard L.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine
  摘要：SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through its GAP enzymatic activity, SYNGAP1 plays an important structural role through its interaction with postsynaptic density proteins. Here, we reveal that intrinsic excitability deficits and seizure phenotypes in heterozygous Syngap1 knockout (KO) mic...
• The ins and outs of plant specialized metabolite gene organization AI翻译
  作者：Dixon, Richard A.
  作者单位：University of North Texas System; University of North Texas Denton; University of North Texas System; University of North Texas Denton
• Conserved C143 forms a branched intermediate in Hedgehog autoprocessing: A cancer drug discovery target against Hedgehog signaling AI翻译
  作者：Faris, Shannon; Xia, Ke; Wagner, Andrew G.; Xu, Zihan; Smith, Nathan; Giner, Jose-Luis; Callahan, Brian; Xie, Jian; Wang, Chunyu
  作者单位：Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; State University of New York (SUNY) System; University at Albany, SUNY; Binghamton University, SUNY; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) College of Environmental Science & Forestry; University of Nebraska System; University of Nebraska Medical Center
  摘要：Hedgehog (Hh) signaling plays fundamental roles in embryonic development while its abnormal activation in adults is associated with cancer. Hh targeting drugs have gained FDA approval but resistance emerged quickly, underlining the need for novel types of Hh inhibitors. Hh signaling is initiated by the Hh ligand, generated from the autoprocessing of Hh precursor. However, the catalytic role of a highly conserved Hedgehog residue C143 is still poorly understood. Here, we confirmed that C143 is ...