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作者：Chavali, Sai Shashank; Carman, Peter J.; Shuman, Henry; Ostap, E. Michael; Sindelar, Charles, V
作者单位：Yale University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Myosin- IC (myo1c) is a class- I myosin that supports transport and remodeling of the plasma membrane and membrane- bound vesicles. Like other members of the myosin family, its biochemical kinetics are altered in response to changes in mechanical loads that resist the power stroke. However, myo1c is unique in that the primary force- sensitive kinetic transition is the isomerization that follows ATP binding, not ADP release as in other slow myosins. Myo1c also powers actin gliding along curved ...
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作者：Garaizar, Adiran; Diaz-Oviedo, David; Zablowsky, Nina; Rissanen, Sami; Koebberling, Johannes; Sun, Jiawei; Steiger, Christoph; Steigemann, Patrick; Mann, Florian A.; Meier, Katharina
作者单位：Bayer AG; Bayer Healthcare Pharmaceuticals; Bayer AG; Bayer CropScience; Bayer AG; Bayer Healthcare Pharmaceuticals
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作者：Abraham, Katharine G.
作者单位：University System of Maryland; University of Maryland College Park
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作者：Jones, Benjamin L. H.; Eklof, Johan S.; Unsworth, Richard K. F.; Coals, Lucy; Christianen, Marjolijn J. A.; Clifton, Julian; Unsworth, Leanne C. Cullen-; Castro, Maricela de la Torre-; Esteban, Nicole; Huxham, Mark; Jiddawi, Narriman S.; Mckenzie, Len J.; Nakaoka, Masahiro; Nordlund, Lina M.; Ooi, Jillian L. S.; Prathep, Anchana
作者单位：State University System of Florida; Florida International University; Stockholm University; Swansea University; Deakin University; Wageningen University & Research; Curtin University; Stockholm University; Edinburgh Napier University; University of Dar es Salaam; James Cook University; Hokkaido University; Uppsala University; Universiti Malaya; Prince of Songkla University
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作者：Rachuri, Swaksha; Nepal, Binod; Shukla, Anurag; Ramanathan, Aarti; Morrisey, Joanne M.; Daly, Thomas; Mather, Michael W.; Bergman, Lawrence W.; Kortagere, Sandhya; Vaidya, Akhil B.
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作者：Ziabari, Omid Saleh; Liu, Fangzhou; Deem, Kevin D.; Liu, Xiaomi; Kholwadwala, Akhil; Brisson, Jennifer A.
作者单位：University of Rochester; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Understanding how morphology evolves requires identifying the types of mutations that contribute to changes in development. We integrated comparative genomics and transcriptomics to reconstruct the evolution and regulation of follistatin paralogs in relation to the evolution of aphid winged and wingless morphs. We find that different pea aphid follistatin duplicates play an essential molecular role in both the male and female wing dimorphisms, linking the genetic and environmental control of m...
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作者：Zittlau, Katharina I.; Zachor-Movshovitz, Daniel; Leushkin, Yegor; Brener, Roy Schimmel; Morgenstern, David; Ben-Nissan, Gili; Sharon, Michal
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science
摘要：The proteasome is a multisubunit degradation machinery that is essential for maintaining protein homeostasis by breaking down unnecessary or damaged proteins into peptides. While most of these peptides are further processed into amino acids, a subset evades complete degradation and plays key roles in biological processes such as antigen presentation, signaling, and apoptosis. However, the variability in peptide lengths and the diverse composition of proteasomes make their comprehensive identif...
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作者：Ikeda, Toma; Nojima, Tatsuya; Yamamoto, Souma; Yamada, Ryusei; Niwa, Tatsuya; Konno, Hiroki; Taguchi, Hideki
作者单位：Institute of Science Tokyo; Tokyo Institute of Technology; Institute of Science Tokyo; Tokyo Institute of Technology; Kanazawa University; Kanazawa University; Kanazawa University
摘要：According to classical Anfinsen's dogma, a protein folds into a single unique confor-mation with minimal Gibbs energy under physiological conditions. However, certain proteins may fold into two or more conformations from single amino acid sequences. Here, we designed a protein that adopts interconvertible alternative functional confor-mations, termed seesaw protein (SSP). An SSP was engineered by fusing GFP lacking the C- terminal beta- strand and dihydrofolate reductase (DHFR) lacking the N- ...
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作者：Proffitt, Tomos; Medeiros, Paula de Sousa; Martins, Waldney Pereira; Luncz, Lydia, V
作者单位：Max Planck Society; Universidade do Algarve; Universidade Estadual de Montes Claros; Universidade Estadual de Montes Claros
摘要：The evolution of stone tool technology marks a significant milestone in hominin devel-opment, enabling early humans to manipulate their environments. The oldest known evidence, dating to 3.3 Ma, indicates a combination of percussive and flake production activities. Studying the archaeological signature of percussive stone tool use in living primate provides a potential analog to the origin of stone flake technology in the hom-inin lineage. Here, we present a yellow- breasted capuchin (Sapajus ...
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作者：Hentzschel, Franziska; Binder, Annika M.; Dorner, Lilian P.; Herzel, Lea; Nuglisch, Fenja; Sema, Meslo; Roever, Katharina; He, Buyuan; Aguirre-Botero, Manuela C.; Cyrklaff, Marek; Funaya, Charlotta; Frischknecht, Friedrich
作者单位：Ruprecht Karls University Heidelberg; German Center for Infection Research; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Ruprecht Karls University Heidelberg
摘要：Microtubule inner proteins (MIPs) are microtubule- associated proteins that bind to tubulin from the luminal side. MIPs can be found in axonemes to stabilize flagellar beat or within cytoplasmic microtubules. Plasmodium spp. are the causative agents of malaria that feature different parasite forms across a complex life cycle with both unique and divergent microtubule-based arrays. Here, we investigate four MIPs in a rodent malaria parasite for their role in transmission to and from the mosquit...
