2025

最新文章

• Genomic map of the functionally extinct northern white rhinoceros (Ceratotherium simum cottoni) AI翻译
  作者：Wang, Gaojianyong; Korody, Marisa L.; Braendl, Bjoern; Hernandez-Toro, Camilo Jose; Rohrandt, Christian; Hong, Karl; Pang, Andy Wing Chun; Lee, Joyce; Migliorelli, Giovanna; Stanke, Mario; Ford, Sarah M.; Pollmann, Iris; Houck, Marlys L.; Lewin, Harris A.; Lear, Teri L.; Ryder, Oliver A.; Meissner, Alexander; Loring, Jeanne F.; Mueller, Franz-Josef
  作者单位：Max Planck Society; University of Kiel; University of Kiel; Schleswig Holstein University Hospital; University of Kiel; Universitat Greifswald; Universitat Greifswald; University of California System; University of California Santa Cruz; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of Kentucky; Scripps Research Institute
  摘要：The northern white rhinoceros (NWR; Ceratotherium simum cottoni) is functionally extinct, with only two nonreproductive females alive. Efforts to rescue the NWR from its inevitable demise have inspired the exploration of unconventional conservation methods, including the development of induced pluripotent stem cells (iPSCs) for the in vitro generation of artificial gametes. The integrity of iPSC genomes is critical for in vitro gametogenesis to be used for assisted reproductive technologies us...
• Genetic associations with socioeconomic status are limited in explaining the socioeconomic health gradient AI翻译
  作者：Fueller, David; Sasko, Benjamin; Ritter, Oliver
  作者单位：St. Marien Hospital; Ruhr University Bochum
• Prioritizing urban heat adaptation infrastructure based on multiple outcomes: Comfort, health, and energy AI翻译
  作者：Jiang, Timothy; Krayenhoff, E. Scott; Martilli, Alberto; Nazarian, Negin; Stone Jr, Brian; Voogt, James A.
  作者单位：University of Guelph; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University System of Georgia; Georgia Institute of Technology; Western University (University of Western Ontario)
  摘要：Globally, cities face increasing extreme heat, impacting comfort, health, and energy consumption. Infrastructure- based heat adaptation strategies can improve these outcomes, but each strategy has a unique mix of benefits and drawbacks. Here, we apply an urbanized meteorological model (WRF) with the newly integrated multilayer BEP- Tree street tree model to dynamically downscale Earth System Model projections and a 3- D microclimate model (TUF- Pedestrian) to simulate the street- scale radiati...
• Real- world implementation of a noninvasive, AI-augmented, anemia-screening smartphone app and personalization for hemoglobin level self-monitoring AI翻译
  作者：Mannino, Robert G.; Sullivan, Julie; Frediani, Jennifer K.; George, Paul; Whitson, Jeremy; Tumlin, James; Lyon, L. Andrew; Tyburski, Erika A.; Lam, Wilbur A.
  作者单位：Emory University; Children's Healthcare of Atlanta (CHOA); Emory University; Chapman University System; Chapman University; Chapman University System; Chapman University; University System of Georgia; Georgia Institute of Technology; Emory University
  摘要：Anemia, characterized by low blood hemoglobin (Hgb) levels, afflicts >2 billion individuals worldwide. Here, we report real-world data generated by a smartphone app that noninvasively screens for anemia using only fingernail selfies. App data for anemia screening were obtained from >1.4 million uses across the United States enabling geographic mapping of Hgb levels. Of those, 9,061 users also self-reported complete blood count Hgb levels for comparison, resulting in accuracy and performance th...
• Time-varying global energy budget since 1880 from a reconstruction of ocean warming AI翻译
  作者：Wu, Quran; Gregory, Jonathan M.; Zanna, Laure; Khatiwala, Samar; Cazenave, Anny
  作者单位：University of Reading; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; Met Office - UK; Hadley Centre; New York University; New York University; Waseda University
  摘要：The global energy budget is fundamental for understanding climate change. It states that the top-of-atmosphere imbalance between radiative forcing (which drives climate change) and radiative response (which resists the forcing) equals energy storage in Earth's heat reservoirs (i.e. the ocean, atmosphere, land, and cryosphere). About 90% of Earth's energy imbalance is stored as heat content in the ocean interior, which is poorly sampled before 1960. Here, we reconstruct Earth's energy imbalance...
• Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain AI翻译
  作者：Compton, Austin; Sharma, Atashi; Hempel, Melanie; Aryan, Azadeh; Biedler, James K.; Potters, Mark B.; Chandrasegaran, Karthikeyan; Vinauger, Clement; Tu, Zhijian
  作者单位：Oxford Nanopore Technologies; Jackson Laboratory; Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University; University of California System; University of California Riverside
  摘要：Diverse genetic strategies are being pursued to control mosquito-borne infectious diseases. These strategies often rely on the release of nonbiting males to either reduce the target mosquito population or render them resistant to pathogens. Male-only releases are important as any contaminating females can bite and potentially transmit pathogens. Despite significant efforts, it remains a major bottleneck to reliably and efficiently separate males from females, especially when nontransgenic male...
• Differentiated planetesimals record differing sources of sulfur in inner and outer solar system materials AI翻译
  作者：Heiny, Elizabeth A.; Stolper, Edward M.; Eiler, John M.
  作者单位：California Institute of Technology
  摘要：The isotope anomalies of noncarbonaceous (NC) and carbonaceous (CC) extraterrestrial materials provide a framework for tracing the distribution and accretion of matter in the early solar system. Here, we extend this framework to sulfur (S)-one of six life-essential volatile elements [T-C similar to 664 K]-via the mass-independent S-isotope compositions of differentiated meteorites. We observe that on average, NC and CC iron meteorites are characterized by distinct Delta S-33 (Delta S-33(NC) = ...
• A universal strategy for multicolor organic circularly polarized afterglow materials with high dissymmetry factors AI翻译
  作者：Yin, Chenjia; Sun, Siyu; Yan, Zi-Ang; Hu, Honglong; Jiang, Ping; Xu, Zhuoran; Tian, He; Ma, Xiang
  作者单位：East China University of Science & Technology; East China University of Science & Technology; East China University of Science & Technology
  摘要：Materials with pure organic circularly polarized afterglow (CPA) have attracted significant attention due to their spatiotemporal-resolved optical properties, yet achieving simultaneous high dissymmetry factor (glum) and multicolor ultralong emission remains a challenge. Here, we establish a universal energy transfer-photon coupling strategy to realize CPA spanning from blue to red with record-high glum (up to 1.90) and ultralong lifetimes (>6 s). Systematic characterization of nonchiral donor...
• Single- cell elderly blood-CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus AI翻译
  作者：Duy, Phan Q.; Kiziltug, Emre; Greenberg, Ana B. W.; Mehta, Neel H.; Hao, Le T.; Fortes, Carla; Mullany, Susan; Fan, Baojian; Manichaikul, Ani; Teich, Andrew F.; Chan, Diane; Alper, Seth L.; Hyman, Bradley T.; Arnold, Steven E.; Mckhann, Guy M.; Frosch, Matthew P.; Kahle, Kristopher T.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Virginia; Columbia University; Columbia University; Columbia University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Columbia University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：We have generated a single-cell RNA sequencing atlas of peripheral blood and ventricular CSF in idiopathic normal pressure hydrocephalus (iNPH) patients totaling 140,207 single-cell transcriptomes. We found proinflammatory alterations in peripheral blood and CSF monocytes in iNPH patients with lower baseline cognitive function. We also identified CSF cell populations likely representing periventricular sloughing of degenerating neuroglial cells. Our findings suggest possible immune dysregulati...
• Rab32 regulates Golgi structure and cell migration through Protein Kinase A-mediated phosphorylation of Optineurin AI翻译
  作者：Johnson, Katherine M.; Marley, Maxwell G.; Drizyte -Miller, Kristina; Chen, Jing; Cao, Hong; Mostafa, Nourhan; Schott, Micah B.; Mcniven, Mark A.; Razidlo, Gina L.
  作者单位：Mayo Clinic; Mayo Clinic; Mayo Clinic; University of Nebraska System; University of Nebraska Medical Center
  摘要：Rab32 is a small GTPase and molecular switch implicated in vesicular trafficking. Rab32 is also an A-Kinase Anchoring Protein (AKAP), which anchors cAMP-dependent Protein Kinase (PKA) to specific subcellular locations and specifies PKA phosphorylation of nearby substrates. Surprisingly, we found that a form of Rab32 deficient in PKA binding (Rab32 L188P) relocalized away from the Golgi apparatus and induced a marked disruption in Golgi organization, assembly, and dynamics. Although Rab32 L188P...