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作者：Keais, Graeme L.; Saad-Roy, Chadi M.; Gonzalez-Sqalli, Emmanuel; Powell, Candice N.; Rieseberg, Loren H.; Gawryluk, Ryan M. R.; van den Driessche, P.; Wei, Kevin H. -C.; Loppin, Benjamin; Perlman, Steve J.
作者单位：University of Victoria; University of British Columbia; University of British Columbia; University of California System; University of California Berkeley; University of California System; University of California Berkeley; CHU Lyon; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Universite Jean Monnet; Institut National de la Sante et de la Recherche Medicale (Inserm); CNRS - National Institute for Biology (INSB); University of Victoria; University of British Columbia
摘要：Meiotic drivers are selfish genetic elements that bias their own transmission during meiosis or gamete formation. Due to the fundamental differences between male and female meiosis in animals and plants, meiotic drivers operate through distinct mechanisms in the two sexes: In females, they exploit the asymmetry of meiosis to ensure their inclusion in the egg, whereas in males, they eliminate competing gametes after symmetric meiosis. Meiotic drive is commonly reported in males, where it strong...
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作者：Rowley-Conwy, Peter
作者单位：Durham University
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作者：Yokoyama, Tatsuhiko; Miyazaki, Ryoji; Suzuki, Takehiro; Dohmae, Naoshi; Nagai, Hiroki; Tsukazaki, Tomoya; Kubori, Tomoko; Akiyama, Yoshinori
作者单位：Gifu University; Nara Institute of Science & Technology; RIKEN; Gifu University; Kyoto University
摘要：TonB-dependent signal transduction is a versatile mechanism observed in gram-negative bacteria that integrates energy-dependent substrate transport with signal relay. In Escherichia coli, the TonB-ExbBD motor complex energizes the TonB-dependent outer membrane transporter FecA, facilitating ferric citrate import. FecA also acts as a sensor, transmitting signals to the cytoplasmic membrane protein FecR, which eventually activates the cytoplasmic sigma factor FecI, driving transcription of the f...
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作者：Rathbone, Harry W.; Houdusse, Anne
作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite PSL; UNICANCER; Institut Curie
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作者：Chandler, Laurel C.; Gardner, Apolonia; Cepko, Constance L.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard Medical School
摘要：Retinitis pigmentosa (RP) is the most common cause of inherited retinal degeneration worldwide. It is characterized by the sequential death of rod and cone photoreceptors, the cells responsible for night and daylight vision, respectively. Although the expression of most RP genes occurs only in rods, there is a secondary degeneration of cones. One possible mechanism of cone death is metabolic dysregulation. Photoreceptors are highly metabolically active, consuming large quantities of glucose an...
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作者：Mo, Xiaoyi; Meng, Keyu; Xu, Bohan; Li, Zehui; Lan, Shanwei; Ren, Zhengda; Xiang, Xin; Zou, Peiqian; Chen, Zesen; Lai, Zhongming; Ao, Xiang; Liu, Zhongyuan; Shang, Wanjing; Dai, Bingyang; Luo, Li; Xu, Jiajia; Wang, Zhizhang; Zhang, Zhongmin
作者单位：Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Hong Kong Polytechnic University; Hong Kong Polytechnic University; Sun Yat Sen University
摘要：Increased differentiation or activity of osteoclasts is the key pathogenic factor of postmenois a novel posttranscriptional mRNA modification related to many diseases. However, its impact on regulating osteoclast activation in PMOP remains uncertain. Here, we initially observed that Nat10- mediated ac4C positively correlates with osteoclast differentiation of monocytes and low bone mass in PMOP. The specific knockout of Nat10 in monocytes and remodelin, a Nat10 inhibitor, alleviates ovariectom...
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作者：Ouyang, Xu; Zeng, Yixuan; Wang, Zi; Bo, Baichuan; Lai, Fangxing; Zhang, Chi; Qiu, Cheng-wei; Song, Qinghai; Yu, Shaohua; Kivshar, Yuri; Xiao, Shumin
作者单位：Harbin Institute of Technology; National University of Singapore; Australian National University; Shanxi University
摘要：The concept of a geometric phase has sparked a revolution in photonics. Conventional space- variant polarization manipulation in optical systems only results in broadband geometric phases. Recently emerged nonlocal metasurfaces show an ability to compress the operating bandwidth through modulations of wavelength- dependent amplitudes. However, their geometric phases are still broadband and not linear, posing severe challenges to realize ultra narrowband metadevices. Here, we propose and demons...
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作者：Anbuhl, Kelsey L.; Castro, Marielisa Diez; Lee, Nikki A.; Lee, Vivian S.; Sanes, Dan H.
作者单位：New York University; Creighton University; New York University; New York University; New York University
摘要：We often exert greater cognitive resources (i.e., listening effort) to understand speech under challenging acoustic conditions. This mechanism can be overwhelmed in those with hearing loss, resulting in cognitive fatigue in adults and potentially impeding language acquisition in children. However, the neural mechanisms that support listening effort are uncertain. Evidence from human studies suggests that the cingulate cortex is engaged under difficult listening conditions and may exert top-dow...
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作者：Chaikin, Claire A.; Thakkar, Abhishek, V; Steffeck, Adam W. T.; Pfrender, Eric M.; Hung, Kaitlyn; Zhu, Pei; Waldeck, Nathan J.; Nozawa, Rino; Song, Weimin; Futtner, Christopher R.; Quattrocelli, Mattia; Bass, Joseph; Ben-Sahra, Issam; Peek, Clara B.
作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati
摘要：Disruptions of circadian rhythms are widespread in modern society and lead to accelerated and worsened symptoms of metabolic syndrome. In healthy mice, the circadian clock factor BMAL1 is required for skeletal muscle function and metabolism. However, the importance of muscle BMAL1 in the development of metabolic diseases, such as diet- induced obesity (DIO), remains unclear. Here, we demonstrate that skeletal muscle-specific BMAL1- deficient mice exhibit worsened glucose tolerance upon high- f...
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作者：Sondermann, Philipp; Diercks, Christian S.; Rong, Cynthia; Schultz, Peter G.
作者单位：Scripps Research Institute; Scripps Research Institute
摘要：There is considerable interest in the targeted degradation of proteins implicated in human disease. The use of sequence-specific proteases for this purpose is severely limited by the difficulty in engineering the numerous enzyme-substrate interactions required to yield highly selective proteases while maintaining catalytic activity. Herein, we report a strategy to evolve a protease for the programmed degradation of alpha- Synuclein, a pre-synaptic protein closely linked to Parkinson's disease....
