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作者：Stewart, Jared J.; Allen, Brendan S.; Polutchko, Stephanie K.; Ocheltree, Troy W.; Gleason, Sean M.
作者单位：United States Department of Agriculture (USDA); University of Colorado System; University of Colorado Boulder; Colorado State University System; Colorado State University Fort Collins
摘要：Plant hydraulic dysfunction by embolism formation can impair photosynthesis, growth, and reproduction and, in severe cases, lead to death. Embolism reversal, or refilling, is a hypothesized adaptive process in which xylem functionality is rapidly and sustainably restored. This study investigated xylem embolism refilling during recovery from severe drought stress using entirely noninvasive measurements of the same plants. These results were considered in relation to functional traits to address...
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作者：Benn, Georgina; V. Mikheyeva, Irina; Inns, Patrick George; Forster, Joel C.; Ojkic, Nikola; Bortolini, Christian; Ryadnov, Maxim G.; Kleanthous, Colin; Silhavy, Thomas J.; Hoogenboom, Bart W.
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作者：Eilersen, Andreas; Bjornstad, Ottar N.; Li, Ruiyun; Schreiber, Sebastian J.; Pei, Zeyuan; Stenseth, Nils Chr.
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Roskilde University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Oslo; Nanjing Medical University; Nanjing University; Nanjing Normal University; University of California System; University of California Davis; University of Oslo; Tsinghua University
摘要：To understand infectious disease dynamics, we need to understand the inextricably intertwined nature of the ecology and evolution of pathogens and hosts. Epidemiological dynamics of many infectious diseases have highlighted the importance of considering the demographics of the societies in which they spread, particularly with respect to age structure. In addition, the waves of the recent COVID-19 pandemic driven by variant replacements at an unprecedented speed show that it is vital to conside...
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作者：Rau, Eli G.; Stokes, Susan C.
作者单位：Tecnologico de Monterrey; University of Chicago
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作者：Yao, Yao; Pankow, Robert M.; Huang, Wei; Wu, Cui; Gao, Lin; Cho, Yongjoon; Chen, Jianhua; Zhang, Dayong; Sharma, Sakshi; Liu, Xiaoxue; Wang, Yuyang; Peng, Bo; Chung, Sein; Cho, Kilwon; Fabiano, Simone; Ye, Zunzhong; Ping, Jianfeng; Marks, Tobin J.; Facchetti, Antonio
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作者：Molitor, Tyler P.; Hayashi, Genki; Lin, Mei-Yao; Dunn, Carissa J.; Peterson, Nathan G.; Poston, Robert G.; Kurnellas, Michael P.; Traver, David A.; Patel, Seona; Akgungor, Zeynep; Leonardi, Virginia; Lewis, Colizel; Segales, Joshua S.; Bennett, Dylan S.; Truong, Anh P.; Dani, Manjari; Naphade, Swati; Wong, Jamie K.; McDermott, Annie E.; Kovalev, Sarah M.; Ciaccio, Gillian L.; Sadiq, Saud A.; Pei, Zhonghua; Wood, Stephen; Rassoulpour, Arash
摘要：GWAS have identified tyrosine kinase 2 (TYK2) variants in multiple inflammatory disorders, specifically a protective hypomorphic TYK2 allele (P1104A) in multiple sclerosis (MS). Impaired TYK2 signaling within the central nervous system (CNS) may impart the protective effects of TYK2 P1104A allele in MS. We deployed brain- penetrant TYK2 inhibitors (cTYK2i) alongside the peripherally restricted TYK2 inhibitor (pTYK2i; BMS- 986165) to untangle the contributions of central TYK2 inhibition in dive...
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作者：Hu, Zhaolong; Baer, Alexander; Hering, Lars; Oliveira, Ivo de Sena; Poulhazan, Alexandre; Browne, Darren C.; Guo, Xue; Perrin, Quentin Moana; Sobota, Radoslaw M.; Hoon, Shawn; Mayer, Georg; Kannan, Srinivasaraghavan; Verma, Chandra S.; Harrington, Matthew J.; Miserez, Ali
作者单位：Nanyang Technological University; McGill University; Universitat Kassel; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Agency for Science Technology & Research (A*STAR); A*STAR - Bioinformatics Institute (BII); National University of Singapore; Nanyang Technological University
摘要：The slime of velvet worms (Onychophora) is a protein- based bioadhesive that undergoes rapid, yet reversible transition from a fluid into stiff fibers used for prey capture and defense, but the mechanism by which this phase transition functions is largely unknown. Here, integrating transcriptomic and proteomic approaches with AI- guided structure predictions, we discover a group of evolutionarily conserved leucine- rich repeat (LRR) proteins in velvet worm slime that readily adopt a receptor- ...
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作者：Usmani, Mahrukh; Coudray, Nicolas; Riggi, Margot; Raghu, Rishwanth; Ramchandani, Harshita; Bobe, Daija; Kopylov, Mykhailo; Zhong, Ellen D.; Iwasa, Janet H.; Ekiert, Damian C.; Bhabha, Gira
作者单位：Johns Hopkins University; New York University; New York University; Utah System of Higher Education; University of Utah; Princeton University
摘要：Microsporidia are divergent fungal pathogens that employ a unique harpoon-like apparatus called the polar tube (PT) to invade host cells. The long PT is fired out of the microsporidian spore over the course of just a few hundred milliseconds. Once fired, the PT is thought to pierce the plasma membrane of a target cell and act as a conduit for the transfer of the parasite into the host cell, which initiates infection. The PT architecture and its association with neighboring organelles within th...
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作者：Suri, Mokshin; Jazi, Farshid Salimi; Crowley, Jack C.; Park, Youngchan; Fu, Bing; Chen, Peng; Zipfel, Warren R.; Barstow, Buz; Hanrath, Tobias
作者单位：Cornell University; Cornell University; Cornell University; Cornell University; Cornell University; Cornell University; City University of Hong Kong
摘要：Integrating the optoelectronic properties of quantum dots (QDs) with biological enzymatic systems to form microbe-semiconductor biohybrids offers promising prospects for both solar-to-chemical conversion and light-modulated biochemical processes. Developing these nano-bio hybrid systems necessitates a deep understanding of charge-transfer dynamics at the nano-bio interface. Photoexcited carrier transfer from QDs to microbes is driven by complex interactions, with emerging insights into the rel...
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作者：Goret, Marie; Thomas, Morgane; Edelweiss, Evelina; Messaddeq, Nadia; Laporte, Jocelyn
作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要：Charcot-Marie-Tooth (CMT) disease, the most common inherited neuromuscular disorder, manifests as progressive muscle weakness and peripheral nerve defects. Dominant mutations in DNM2, encoding the large GTPase dynamin 2, result in CMT without any suggested therapeutic strategy. Different dominant mutations in DNM2 also cause centronuclear myopathy (CNM), and increasing BIN1 (amphiphysin 2), an endogenous modulator of DNM2, rescued CNM in mice. Here, we found that increasing BIN1 level exacerba...
