2025

最新文章

• Protective antigen-mediated delivery of an anti-CRISPR protein for precision genome editing AI翻译
  作者：Vera, Axel O.; Truex, Nicholas L.; Sreekanth, Vedagopuram; Pentelute, Bradley L.; Choudhary, Amit; Raines, Ronald T.
  作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); University of South Carolina System; University of South Carolina Columbia
  摘要：Precise control over the dosage of Cas9-based technologies is essential because off-target effects, mosaicism, chromosomal aberrations, immunogenicity, and genotoxicity can arise with prolonged Cas9 activity. Type II anti-CRISPR proteins (Acrs) inhibit and control Cas9 but are generally impermeable to the cell membrane due to their size and anionic charge. Moreover, existing Acr delivery methods are long-lived and operate within hours (e.g., viral and nonviral vectors) or require external devi...
• Familial transmission of neural representations for mental arithmetic across two generations AI翻译
  作者：Constant-Varlet, Charlotte; Nakai, Tomoya; Longo, Lea; Bouchet, Honorine; Prado, Jerome
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean Monnet; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Universite Paris Cite
  摘要：Parental skills are among the most powerful predictors of children's outcomes. While distal genetic and environmental pathways likely contribute to skill transmission within families, much less is known about the proximal neural markers that support the transmission of cognitive functioning from parents to children. It is also unclear whether brain similarity between parents and children predicts similarity in cognitive skills. In this study, we used fMRI to measure brain activity associated w...
• Integrating spatial omics and single- cell mass spectrometry imaging reveals tumor-host metabolic interplay in hepatocellular carcinoma AI翻译
  作者：Chen, Panpan; Geng, Haoyuan; Ma, Bangzhen; Zhang, Yaqi; Zhu, Zihan; Li, Min; Chen, Shiping; Wang, Xiao; Sun, Chenglong
  作者单位：Qilu University of Technology; Qilu University of Technology; Shandong First Medical University & Shandong Academy of Medical Sciences
  摘要：Metabolic crosstalk among diverse cellular populations contributes to shaping a competitive and symbiotic tumor microenvironment (TME) to influence cancer progression and immune responses, highlighting vulnerabilities that can be exploited for cancer therapy. Using a spatial multiomics platform to study the cell- specific metabolic spectrum in hepatocellular carcinoma (HCC), we map the metabolic interactions between different cells in the HCC TME and identify a unique tumor- immune- cancer- as...
• Neuronal processes contain the essential components for the late steps of ribosome biogenesis AI翻译
  作者：Fusco, Claudia M.; Staab, Anja; Bourke, Ashley M.; Tushev, Georgi; Desch, Kristina; Lins, Erico Moreto; Ciirdaeva, Elena; Dieck, Susanne tom; Kaltenschnee, Nina; Heckel, Alexander; Langer, Julian D.; Schuman, Erin M.
  作者单位：Max Planck Society; Goethe University Frankfurt
  摘要：Neurons rely on spatial and temporal control of protein synthesis to respond rapidly and locally to external stimuli, a process facilitated by the dynamic localization and modification of ribosomes. While previous research has shown that neuronal activity can regulate ribosome localization and modify translation rates, little is known about ribosomal assembly within neuronal processes. Here, we investigated the potential for local ribosome maturation in rat neurons using proteomics, RNA sequen...
• Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson's disease AI翻译
  作者：Nair, Sreeja, V; Jaimon, Ebsy; Adhikari, Ayan; Nikoloff, Jonas; Pfeffer, Suzanne R.
  作者单位：Stanford University
  摘要：Parkinson's disease is characterized by loss of dopamine neurons that project to the dorsal striatum, and mutations in LRRK2 and GBA1 are the most common genetic causes of familial Parkinson's disease. Previously, we showed that pathogenic LRRK2 mutations inhibit primary cilia formation in rare interneurons and astrocytes of the mouse and human dorsal striatum. This blocks Hedgehog signaling and reduces synthesis of neuroprotective GDNF and NRTN, which normally support dopamine neurons vulnera...
• ELAPOR1 is a copper- dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis AI翻译
  作者：Shao, Tianyu; Ma, Jiahao; Tan, Xinshui; Shan, Hongcheng; Xu, Dan; Zhang, Kexin; Zheng, Sanduo; Wang, Fengchao
  作者单位：Peking University; National Institute of Biological Sciences, Beijing; Tsinghua University; Chinese Institute for Brain Research, Beijing
  摘要：The acrosome is a crucial organelle essential for sperm function and male fertility. During acrosome biogenesis, numerous proacrosomal vesicles (PAVs) are transported to the concave region of the nuclear membrane and fuse to form the acrosome. However, the mechanisms governing the fusion of PAVs to form the acrosome remain poorly understood. Here, we identify endosome-lysosome associated apoptosis and autophagy regulator 1 (ELAPOR1), a conserved protein, as a key factor in PAVs fusion during a...
• Three things we can do now to reduce the risk of avian influenza spillovers AI翻译
  作者：Yeh, Kenneth B.; Bahnfleth, William P.; Bradforda, Elaine; Cardona, Carol; Coleman, Kristen K.; Hudson, Peter J.; Dadonaite, Bernadeta; Hutchins, Rebecca J.; Maresso, Anthony; Macintyre, C. Raina; Scotch, Matthew
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Minnesota System; University of Minnesota Twin Cities; University System of Maryland; University of Maryland College Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University System of Georgia; Georgia Institute of Technology; Baylor College of Medicine; University of New South Wales Sydney; Kirby Institute; Arizona State University; Arizona State University-Downtown Phoenix
• Intranasal measles virus-and mumps virus-based SARS-CoV-2 vaccine candidates prevent SARS-CoV-2 infection and transmission AI翻译
  作者：Hsu, Cheng Chih; Chamblee, Michelle; Ye, Chengjin; Shamseldin, Mohamed M.; Yoo, Sung J.; Li, Pei; Zhang, Yuexiu; Liu, Yajie; Hall, Jesse M.; Xu, Jiayu; Miao, Hanson; Thongpan, Ilada; Mahesh, K. C.; Liang, Xueya; Yount, Jacob S.; Peeples, Mark E.; Boyaka, Prosper N.; Dubey, Purnima; Martinez-Sobrido, Luis; Liu, Shan-Lu; Li, Jianrong
  作者单位：University System of Ohio; Ohio State University; Texas Biomedical Research Institute; University System of Ohio; Ohio State University; Egyptian Knowledge Bank (EKB); Helwan University; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：The emergence of immune-evasive SARS-CoV-2 Omicron subvariants highlights the need to develop a mucosal SARS-CoV-2 vaccine that can provide broad protection against virus infection and transmission. Here, we developed an intranasal monovalent SARS-CoV-2 vaccine expressing the six-proline-stabilized prefusion spike proteins (preS-6P) of Omicron XBB.1.5 based on the attenuated mumps virus (MuV) Jeryl Lynn (JL1) vaccine strain. We also developed an intranasal trivalent vaccine expressing the preS...
• Impact of women's political empowerment through gender quotas on improved drinking water access in Africa AI翻译
  作者：An, Jiafu; Wang, Tenghui; Chen, Bin; Gong, Peng; Lin, Chen; Stenseth, Nils Chr.
  作者单位：University of Hong Kong; Lingnan University; University of Hong Kong; University of Hong Kong; University of Hong Kong; Tsinghua University; University of Oslo; University of Oslo
  摘要：Access to safely managed drinking water is a fundamental human right, essential for human health and well- being. However, 2.2 billion people around the world still lack this access, with significant geographical disparities. In this study, we leveraged the implementation of gender quota laws-specifically reserved parliamentary seats for women across African countries-to examine its impact on improved water availability. Our findings reveal that the implementation of gender quotas is associate...
• Tensor-based quantum phase difference estimation for large-scale demonstration AI翻译
  作者：Kanno, Shu; Sugisaki, Kenji; Nakamura, Hajime; Yamauchi, Hiroshi; Sakuma, Rei; Kobayashi, Takao; Gao, Qi; Yamamoto, Naoki
  作者单位：Mitsubishi International Corporation (MIC); Mitsubishi Chemical Holdings Corporation; Mitsubishi Chemical; Keio University; Keio University; Keio University; SoftBank Corporation; JSR Corporation; Keio University
  摘要：We develop an energy calculation algorithm leveraging quantum phase difference estimation (QPDE) scheme and a tensor-network-based unitary compression method in the preparation of superposition states and time-evolution gates. Alongside its efficient implementation, this algorithm reduces depolarization noise affections exponentially. We demonstrated energy gap calculations for one-dimensional Hubbard models on IBM superconducting devices using circuits up to 32-system (plus oneancilla) qubits...