2025

最新文章

• A tale of two planets: Disparate evolutionary models for Mars inferred from radiogenic isotope compositions of Martian meteorites AI翻译
  作者：Borg, Lars E.; Kruijer, Thomas S.
  作者单位：United States Department of Energy (DOE); Lawrence Livermore National Laboratory
  摘要：The radiogenic isotopic compositions of basaltic Martian meteorites (shergottites) and clinopyroxene/olivine cumulate meteorites (nakhlite/chassignites) are used to define the global evolution of Mars. However, the two main groups of meteorites demonstrate that their sources underwent divergent styles of magmatic evolution. The shergottites portray a planet that differentiated similar to 4.52 billion years ago via solidification of a magma ocean, producing incompatible element-depleted and -en...
• Mutational analysis of an antimalarial drug target, PfATP4 AI翻译
  作者：Rachuri, Swaksha; Nepal, Binod; Shukla, Anurag; Ramanathan, Aarti; Morrisey, Joanne M.; Daly, Thomas; Mather, Michael W.; Bergman, Lawrence W.; Kortagere, Sandhya; Vaidya, Akhil B.
  作者单位：Drexel University
  摘要：Among new antimalarials discovered over the past decade are multiple chemical scaffolds that target Plasmodium falciparum P-type ATPase (PfATP4). This essential protein is a Na+ pump responsible for the maintenance of Na+ homeostasis. PfATP4 belongs to the type two-dimensional (2D) subfamily of P-type ATPases, for which no structures have been determined. To gain better insight into the structure/function relationship of this validated drug target, we generated a homology model of PfATP4 based...
• Evolution takes multiple paths to evolvability when facing environmental change AI翻译
  作者：Kumawat, Bhaskar; Lalejini, Alexander; Acosta, Monica M.; Zaman, Luis
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Grand Valley State University
  摘要：Life at all scales is surprisingly effective at exploiting new opportunities, as demonstrated by the rapid emergence of antimicrobial resistance and novel pathogens. How populations acquire this level of evolvability and the various ways it aids survival are major open questions with direct implications for human health. Here, we use digital evolution to show that changing environments facilitate the simultaneous evolution of high mutation rates and a distribution of mutational effects skewed ...
• Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors AI翻译
  作者：Sait, Sameer Farouk; Tang, Kwan Ho; Angus, Steven P.; Brown, Rebecca; Sun, Daochun; Xie, Xuanhua; Iltis, Charlene; Lien, Michelle; Socci, Nicholas D.; Bale, Tejus A.; Davis, Christopher; Dixon, Shelley A. H.; Zhang, Chi; Clapp, D. Wade; Neel, Benjamin G.; Parada, Luis F.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; New York University; AstraZeneca; Indiana University Health; James Whitcomb Riley Hospital Children; Indiana University System; Indiana University Bloomington; Icahn School of Medicine at Mount Sinai; Medical College of Wisconsin; Medical College of Wisconsin; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
  摘要：Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas and the primary cause of mortality in patients with neurofibromatosis type 1 (NF1). These malignancies develop within preexisting benign lesions called plexiform neurofibromas (PNs). PNs are solely driven by biallelic NF1 loss eliciting RAS pathway activation, and they respond favorably to MEK inhibitor therapy. MPNSTs harbor additional mutations and respond poorly to MEK inhibition. Our analysis of genetically engineere...
• Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNAThr production AI翻译
  作者：Xu, Xihui; Penjweini, Rozhin; Szekvolgyi, Lorant; Karanyi, Zsolt; Heckel, Anne- Marie; Gurusamy, Devikala; Varga, Dora; Yang, Shutong; Brown, Alexandra L.; Cui, Wenqi; Park, Jinsung; Nagy, Denes; Podszun, Maren C.; Yang, Sarah; Singh, Komudi; Ashcroft, Stephen P.; Kim, Jeonghan; Kim, Myung K.; Tarassov, Ivan; Zhu, Jun; Philp, Andrew; Rotman, Yaron; Knutson, Jay R.; Entelis, Nina; Chung, Jay H.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of Debrecen; University of Debrecen; Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of Birmingham; Catholic University of Korea; Catholic University of Korea; University of Sydney; NSW Health; Royal Prince Alfred Hospital; University of Technology Sydney
  摘要：Mitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG deficiency causes mitochondrial dysfunction. However, the mechanism by which EndoG regulates mitochondrial function is not known. Fat accumulation in metabolic dysfunction-associated steatotic liver disease (MASLD), which is more common in men, is caused in part by mitochondrial dysfunction. EndoG ...
• US Corn Belt enhances regional precipitation recycling AI翻译
  作者：Zhang, Zhe; He, Cenlin; Chen, Fei; Miguez-Macho, Gonzalo; Liu, Changhai; Rasmussen, Roy
  作者单位：Hong Kong University of Science & Technology; Universidade de Santiago de Compostela
  摘要：Precipitation recycling, where evapotranspiration (ET) from the land surface contributes to precipitation within the same region, is a critical component of the water cycle. This process is especially important for the US Corn Belt, where extensive cropland expansions and irrigation activities have significantly transformed the landscape and affected the regional climate. Previous studies investigating precipitation recycling typically relied on analytical models with simplifying assumptions, ...
• Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance AI翻译
  作者：Le Mouellic, Wendy; Levillain, Florence; Wu, Ting - Di; Caouaille, Maxime; Bousso, Philippe; Poquet, Yannick; Neyrolles, Olivier
  作者单位：Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper understanding of Mycobacterium tuberculosis metabolism could uncover specific vulnerabilities and inform the development of new treatments. Sulfur, essential for bacterial growth and survival, fuels key pathways including redox buffering and coenzyme production. Although previous studies suggest that M. tuberculosis utilizes various substrates to meet it...
• Novelty as a drive of human exploration in complex stochastic environments AI翻译
  作者：Modirshanechi, Alireza; Lin, Wei-Hsiang; Xu, He A.; Herzog, Michael H.; Gerstner, Wulfram
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Max Planck Society
  摘要：In order to find extrinsic rewards, humans explore their environment even if exploration requires several intermediate, reward-free decisions. It has been hypothesized that intrinsic rewards, such as novelty, surprise, or information gain, guide this reward-free exploration. However, in artificial agents, different intrinsic reward signals induce exploration strategies that respond differently to stochasticity. In particular, some strategies are vulnerable to the noisy TV problem, i.e., an att...
• Microbial conservation is essential for sustaining ecosystem functions and services AI翻译
  作者：Junker, Robert R.; Farwig, Nina
• Parametrically guided design of beta barrels and transmembrane nanopores using deep learning AI翻译
  作者：Kim, David E.; Watson, Joseph L.; Juergens, David; Majumder, Sagardip; Sonigra, Ria; Gerben, Stacey R.; Kang, Alex; Bera, Asim K.; Li, Xinting; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
  摘要：Francis Crick's global parameterization of coiled coil geometry has been widely useful for guiding design of new protein structures and functions. However, design guided by similar global parameterization of beta barrel structures has been less successful, likely due to the deviations from ideal barrel geometry required to maintain inter-strand hydrogen bonding without introducing backbone strain. Instead, beta barrels have been designed using two-dimensional structural blueprints; while this ...