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作者：Capps, Mary E. S.; Moyer, Anna J.; Conklin, Claire L.; Martina, Verdion; Olson, Emma G. Torija -; Klein, Morgan C.; Gannaway, William C.; Calhoun, Caleb C. S.; Vivian, Michael D.; Thyme, Summer B.
作者单位：University of Alabama System; University of Alabama Birmingham
摘要：Hundreds of human mutations are linked to autism and related disorders, yet the functions of many of these mutated genes during vertebrate neurodevelopment are unclear. We generated 27 zebrafish mutants with presumptive protein-truncating mutations or specific missense variants corresponding to autism-risk alleles in 17 human genes. We observed baseline and stimulus-driven behavioral changes at larval stages, as well as social behavior differences in lines tested as juveniles. Imaging whole-br...
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作者：Hu, Jiajie; Yu, Dongsheng; Wang, Jiasheng; Guo, Peng; Chen, Mingming; Wu, Dongmei; Cai, Youzhi; Wang, Yixuan; Ji, Junfeng; Yao, Xudong; Ouyang, Hongwei
作者单位：Zhejiang University; Zhejiang University; Liangzhu Laboratory; Zhejiang University; Hangzhou Medical College; Zhejiang Provincial People's Hospital; Zhejiang University; Zhejiang University; Zhejiang University
摘要：Osteoarthritis (OA) is one of the most common causes of physical disability among older people and its incidence increases with age. Removal of the senescent cells (SNCs) delays OA pathologies, but little is known about the heterogeneity of SNCs and their roles in OA pathogenesis. Here, we identify a subpopulation of senescent synovial cells and proposed a molecular mechanism governing pathogenic synovium-cartilage crosstalk in OA progression. Using single-cell RNA sequencing and synovial orga...
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作者：Huang, Peng; Almquist, Zack W.; Butts, Carter T.
作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
摘要：Scientific inquiry about the transmissibility of infectious diseases is largely based on the basic reproduction number (R0) and its derivations. This paper describes a mechanism overlooked in most conventional analyses, in which a disease can endogenously compete with itself when multiple infectious individuals race to infect the same susceptible individual, thereby reducing the effective reproductive rate. Utilizing an empirically calibrated network epidemiological model of wild-type COVID-19...
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作者：Tovar, Ruben U.; Dobbins, Brittany A.; Hartman, Nicholas R.; Leelani, Sheena; Devitt, Thomas J.; Garcia, Dana M.; Gignac, Paul M.; Cannatella, David C.; Hillis, David M.
作者单位：University of Texas System; University of Texas Austin; Texas State University System; Texas State University San Marcos; University of Arizona
摘要：Lineages that have invaded subterranean environments have repeatedly evolved remarkable adaptations to life in darkness. However, observational and experimental studies in additional natural systems are needed to further our understanding of repeated evolution and convergence. In Texas, a radiation of groundwater salamanders (genus Eurycea), with independent invasions of subterranean karstic environments, offers an opportunity to investigate phenotypic convergence, parallel evolution, and the ...
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作者：Molinet, Jennifer; Stelkens, Rike
作者单位：Stockholm University
摘要：The maintenance of biodiversity crucially depends on the evolutionary potential of populations to adapt to environmental change. Accelerating climate change and extreme temperature events urge us to better understand and forecast evolutionary responses. Here, we harnessed the power of experimental evolution with the microbial model system yeast (Saccharomyces spp.) to measure the evolutionary potential of populations to adapt to future warming, in real- time and across the entire phylogenetic ...
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作者：Yu, Jingyou; Zheng, Yi-Min; Sheridan, Megan A.; Li, Pei; Ezashi, Toshihiko; Roberts, R. Michael; Liu, Shan-Lu
作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; State Key Laboratory of Respiratory Disease; Guangzhou Medical University; Guangzhou Laboratory; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
摘要：Zika virus (ZIKV) infection can lead to a variety of clinical outcomes, including severe congenital abnormalities. The phosphatidylserine receptors AXL and TIM-1 are recognized as critical entry factors for ZIKV in vitro. However, it remains unclear whether and how ZIKV regulates these receptors during infection. In this study, we investigated AXL and TIM-1 expression in human lung adenocarcinoma epithelial A549 cells, glioblastoma U87 cells, and embryonic stem cell-derived trophoblasts follow...
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作者：Abundo, Maria Paulene; Tifrea, Anna T.; Buss, Marjorie T.; Larrea, Pierina Barturen -; Jin, Zhiyang; Malounda, Dina; Shapiro, Mikhail G.
作者单位：California Institute of Technology; California Institute of Technology; Howard Hughes Medical Institute
摘要：Delivering biomedicines to specific sites of disease using remote-controlled devices is a long-standing vision in biomedical research. However, most existing externally triggered delivery systems are based on complex micromachines that are controlled with electromagnetic waves and require custom external instrumentation. Here, we present a drug delivery platform based on a simple protein-containing hydrogel that can be both imaged and triggered to release drugs at specific locations using wide...
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作者：Creighton, Maria J. A.; Lerch, Brian A.; Lange, Elizabeth C.; Silk, Joan B.; Tung, Jenny; Archie, Elizabeth A.; Alberts, Susan C.
作者单位：Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Duke University; Duke University; Max Planck Society; Canadian Institute for Advanced Research (CIFAR); University of Notre Dame
摘要：Over the past few decades, studies have provided strong evidence that the robust links between the social environment, health, and survival found in humans also extend to nonhuman social animals. A number of these studies emphasize the early life origins of these effects. For example, in several social mammals, more socially engaged mothers have infants with higher rates of survival compared to less socially engaged mothers, suggesting that positive maternal social relationships causally impro...
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作者：Dong, Chenyu; Faranda, Davide; Gualandi, Adriano; Lucarini, Valerio; Mengaldo, Gianmarco
作者单位：National University of Singapore; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite Paris Saclay; Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut Polytechnique de Paris; Ecole Polytechnique; University of Cambridge; Istituto Nazionale Geofisica e Vulcanologia (INGV); University of Leicester; National University of Singapore
摘要：Nonlinear dynamical systems are ubiquitous in nature and they are hard to forecast. Not only they may be sensitive to small perturbations in their initial conditions, but they are often composed of processes acting at multiple scales. Classical approaches based on the Lyapunov spectrum rely on the knowledge of the dynamic forward operator, or of a data-derived approximation of it. This operator is typically unknown, or the data are too noisy to derive its faithful representation. Here, we prop...
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作者：Wang, Hong; Huang, Jie; Zhang, Zhenhua; An, Yana; Sun, Huizi; Chen, Jianghe; Feng, Weineng; Duan, Hao; Mou, Yonggao; Wang, Yuanxiang; Liu, Peiqing; Zhou, Huihao; Chen, Hong - Wu; Zhang, Jian; Lu, Xiaoyun; Wang, Junjian
作者单位：Sun Yat Sen University; Guangdong Academy of Medical Sciences & Guangdong General Hospital; Southern Medical University - China; Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen University; University of California System; University of California Davis; Sun Yat Sen University; Jinan University
摘要：Small-cell lung cancer (SCLC) is the most lethal type of lung cancer, characterized by rapid evolution from chemosensitivity to chemoresistance and limited treatment options. However, the mechanisms underlying this evolution remain poorly understood. Here, we show that Retinoid X receptor gamma (RXR gamma) is uniquely overexpressed in chemo-resistant SCLC tumors, and that RXR gamma serves as an essential factor driving chemoresistance in SCLC. RXR gamma forms phase-separated droplets with LSD1...
