2025

最新文章

• Population size interacts with reproductive longevity to shape the germline mutation rate AI翻译
  作者：Zhu, Luke; Beichman, Annabel; Harris, Kelley
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center
  摘要：Mutation rates vary across the tree of life by many orders of magnitude, with fewer mutations occurring each generation in species that reproduce quickly and maintain large effective population sizes. A compelling explanation is that large effective population sizes facilitate selection against weakly deleterious mutator alleles such as variants that modulate cell division or interfere with the molecular efficacy of DNA repair. However, while the fidelity of a single cell division largely dete...
• Ecological restructuring of North Tethyan marine vertebrate communities triggered by the end- Cretaceous extinction AI翻译
  作者：Feichtinger, Iris; Harzhauser, Mathias; Pollerspock, Jurgen; Auer, Gerald; Coric, Stjepan; Kranner, Matthias; Kallanxhi, Madalina-Elena; Weinmann, Anna E.; Guinot, Guillaume
  作者单位：University of Graz; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Institut Universitaire de France
  摘要：The ecological upheavals produced by the Cretaceous-Paleogene mass extinction event (K-Pg, -66 Ma) have been mostly studied at large scale with emphasis on clades' diversity dynamics. How this event affected the structure of paleocommunities is comparatively less investigated, especially within large vertebrate clades like fish. Here, we quantified changes in the contribution of elasmobranchs (sharks, skates, rays) and actinopterygians (ray-finned fishes) to the fish community across the K-Pg ...
• Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain AI翻译
  作者：Selig, Emily E.; Sohn, Erich J.; Stoja, Aiola; Moreno-Romero, Alma K.; Akula, Shivani; Xu, Xiaoping; Bishop, Alexander J. R.; Libich, David S.
  作者单位：University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio
  摘要：Ewing sarcoma (EwS) is an aggressive cancer of bone and soft tissue that predominantly affects children and young adults. A chromosomal translocation joins the low-complexity domain (LCD) of the RNA-binding protein EWS (EWSLCD) with the DNA-binding domain of Friend leukemia integration 1 (FLI1(DBD)), creating EWS::FLI1, a potent fusion oncoprotein essential for EwS development and responsible for over 85% of EwS tumors. EWS::FLI1 forms biomolecular condensates in vivo and promotes tumorigenesi...
• Simulating regional workforce impacts of decarbonizing integrated steelmaking AI翻译
  作者：Miles, Jillian; Combemale, Christophe; Karplus, Valerie J.; Pistorius, P. Chris
  作者单位：Carnegie Mellon University; Carnegie Mellon University
  摘要：Global efforts to mitigate climate change are increasing pressure on heavy manufacturing industries to decarbonize production. The iron and steel industry is responsible for 7% of CO2 emissions globally (2% in the United States) and is often a major employer in the regions where iron and steel is produced. Understanding the future prospects for workers in regions with high CO2 emitting industries-including impacts of phasing out or evolving such industries-will be critical for informing region...
• Ab initio stability predictions for rare earth oxyphosphates and experimental confirmation of cerium (III) phases AI翻译
  作者：Wang, Edric X.; Ushakov, Sergey, V; Wang, Ligen; Matteucci, Jared; Xu, Hongwu; Opila, Elizabeth J.; Hong, Qi-Jun; Navrotsky, Alexandra
  作者单位：Arizona State University; Arizona State University-Tempe; University of Illinois System; University of Illinois Urbana-Champaign; Arizona State University; Arizona State University-Tempe; University of Virginia
  摘要：Rare earth oxyphosphates represent a large family of compounds with the general formula (RE2O3)x(REPO4), where RE refers to lanthanides and yttrium. At least four known stoichiometries have been established, each with distinct structures. These compounds have potential applications as refractory coatings, catalysts, and magnetic materials. We modeled the stability of RE3PO7 [RE3(PO4)O3] with respect to rare earth sesquioxides (RE2O3) and orthophosphates (REPO4) using DFT computations with the ...
• Loss of lipid asymmetry facilitates plasma membrane blebbing by decreasing membrane lipid packing AI翻译
  作者：Wang, Hong - Yin; Rumin, Alissa; Doktorova, Milka; Sputay, Daryna; Chan, Sze Ham; Wehman, Ann M.; Levental, Kandice R.; Levental, Ilya
  作者单位：University of Virginia; University of Denver; Stockholm University; Texas A&M University System; Texas A&M University College Station
  摘要：Membrane blebs have important roles in cell migration, apoptosis, and intercellular communication through extracellular vesicles (EVs). While plasma membranes (PM) typically maintain phosphatidylserine (PS) on their cytoplasmic leaflet, most blebs have PS exposed on their outer leaflet, revealing that loss of steady-state lipid asymmetry often accompanies PM blebbing. How these changes in PM lipid organization regulate membrane properties and affect bleb formation remains unknown. We confirmed...
• DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis AI翻译
  作者：Chen, Fangbin; Deng, Zhaohua; Wang, Xiaoming; Liu, Yuxuan; Zhao, Kaichen; Zhang, Yue; He, Simeng; Ran, Rensen; Dong, Yingying; Guo, Shuang; Zhou, Yitong; Zhou, Bin; Pang, Pengfei; Ge, Wei; Liu, Chang; Shan, Hong; He, Huanhuan
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Wuhan University; Huazhong Agricultural University; University of Macau; Beijing Genomics Institute (BGI); Shanxi Medical University; Beijing Genomics Institute (BGI)
  摘要：Vascular development is a precisely controlled process, yet how it is spatiotemporally orchestrated remains enigmatic. We previously identified DEAD-box RNA helicase 24 (DDX24) as a pathogenic gene for multiorgan vascular anomalies. Here, we show that DDX24 is expressed in the endothelium during embryonic angiogenesis in zebrafish. DDX24 deficiency causes intersegmental vessel hyperbranching in the trunk, but inhibits central artery angiogenesis in the brain. Mechanistically, DDX24 deficiency ...
• NEUROD1 efficiently converts peripheral blood cells into neurons with partial reprogramming by pluripotency factors AI翻译
  作者：Saito, Yoichi; Ishikawa, Mitsuru; Ohkuma, Mahito; Moody, Jonathan; Mabuchi, Yo; Sanosaka, Tsukasa; Ando, Yoshinari; Yamashita, Takayuki; Hon, Chung Chau; Shin, Jay W.; Akamatsu, Wado; Okano, Hideyuki
  作者单位：Keio University; Keio University; Fujita Health University; Fujita Health University; RIKEN; Fujita Health University; Hiroshima University; Agency for Science Technology & Research (A*STAR); A*STAR - Genome Institute of Singapore (GIS); National University of Singapore; Juntendo University
  摘要：The direct reprogramming of cells has tremendous potential in in vitro neurological studies. Previous attempts to convert blood cells into induced neurons have presented several challenges, necessitating a less invasive, efficient, rapid, and convenient approach. The current study introduces an optimized method for converting somatic cells into neurons using a nonsurgical approach that employs peripheral blood cells as an alternative source to fibroblasts. We have demonstrated the efficacy of ...
• Persistent inequalities in global air quality monitoring should not delay pollution mitigation AI翻译
  作者：Smith, Keith; Lauriere, Camille Fournier de; Henninger, Ella
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Air pollution is a global health crisis that disproportionately affects lower- and middle-income countries. We examine global air quality monitoring data, highlighting persistent inequalities in high-exposure regions, and assess the potential of emerging technologies to improve data utility for mitigation. Improving air quality, however, does not need to wait for more data, nor will monitoring alone drive action. Immediate mitigation measures with broad cobenefits are needed now to reduce poll...
• Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography AI翻译
  作者：Zhou, Huabin; Hutchings, Joshua; Shiozaki, Momoko; Zhao, Xiaowei; Doolittle, Lynda K.; Yang, Shixin; Yan, Rui; Jean, Nikki; Riggi, Margot; Yu, Zhiheng; Villa, Elizabeth; Rosen, Michael K.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center; University of California System; University of California San Diego; Howard Hughes Medical Institute; Max Planck Society; University of California System; University of California San Diego; Howard Hughes Medical Institute
  摘要：Phase separation is an important mechanism to generate certain biomolecular condensates and organize the cell interior. Condensate formation and function remain incompletely understood due to difficulties in visualizing the condensate interior at high resolution. Here, we analyzed the structure of biochemically reconstituted chromatin condensates through cryoelectron tomography. We found that traditional blotting methods of sample preparation were inadequate, and high- pressure freezing plus f...