2025

最新文章

• Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF AI翻译
  作者：Marongiu, Gian Luca; Fink, Uwe; Schoepf, Felix; Oder, Andreas; von Kries, Jens Peter; Roderer, Daniel
  摘要：Fusobacterium nucleatum (Fn), a commensal in the human oral cavity, is overrepresented in the colon microbiota of colorectal cancer (CRC) patients and is linked to tumor chemoresistance, metastasis, and a poor therapeutic prognosis. Fn produces numerous adhesins that mediate tumor colonization and downregulation of the host's antitumor immune response. One of these, the trimeric autotransCEACAM1 on T- cells and has been associated with immune evasion of Fn- colonized tumors. Whereas the role o...
• Structural basis for neutralizing antibody binding to pertussis toxin AI翻译
  作者：Goldsmith, Jory A.; Nguyen, Annalee W.; Wilen, Rebecca E.; Wijagkanalan, Wassana; Mclellan, Jason S.; Maynard, Jennifer A.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：Pertussis toxin (PT) is a key protective antigen in vaccine-and natural immunity-mediated protection from Bordetella pertussis infection. Despite its importance, no PT-neutralizing epitopes have been characterized structurally. To define neutralizing epitopes and identify key structural elements to preserve during PT antigen design, we determined a 3.6 & Aring; cryoelectron microscopy structure of genetically detoxified PT (PTg) bound to hu11E6 and hu1B7, two potently neutralizing anti-PT anti...
• Anatomy of a range contraction: Flow-phenology mismatches threaten salmonid fishes near their trailing edge AI翻译
  作者：Carlson, Stephanie M.; Pregler, Kasey C.; Obedzinski, Mariska; Gallagher, Sean P.; Rhoades, Suzanne J.; Hazard, Cleo Woelfle -; Queener, Nathan; Thompson, Sally E.; Power, Mary E.
  作者单位：University of California System; University of California Berkeley; United States Department of Defense; United States Army; University of Western Australia; University of Western Australia; University of California System; University of California Berkeley
  摘要：Climate change is redistributing life on Earth, with profound impacts for ecosystems and human well-being. While repeat surveys separated by multidecadal intervals can determine whether observed shifts are in the expected direction (e.g., poleward or upslope due to climate change), they do not reveal their mechanisms or time scales: whether they were gradual responses to environmental trends or punctuated responses to disturbance events. Here, we document population reductions and temporary ra...
• Enamel-dentine junction morphology reveals population replacement and mobility in the late prehistoric Middle Nile Valley AI翻译
  作者：Martin, Nicolas; Thibeault, Adrien; Varadzinova, Lenka; Usai, Donatella; Ambrose, Stanley H.; Antoine, Daniel; Havelkova, Petra Brukner; Honegger, Matthieu; Irish, Joel D.; Jesse, Friederike; Marechal, Laura; Osypinska, Marta; Osypinski, Piotr; Santos, Frederic; Vanderesse, Nicolas; Varadzin, Ladislav; Whiting, Rebecca J.; Zanolli, Clement; Veleminsky, Petr; Crevecoeur, Isabelle
  作者单位：Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Charles University Prague; University of Illinois System; University of Illinois Urbana-Champaign; National Museum; Liverpool John Moores University; University of Wuppertal; University of Geneva; University of Wroclaw; Polish Academy of Sciences; Institute of Archaeology & Ethnology of the Polish Academy of Sciences; Czech Academy of Sciences; Institute of Archaeology of the Czech Academy of Sciences - Prague
  摘要：Transitions from foraging to food-production represent a worldwide turning point in recent human history. In the Middle Nile Valley this cultural shift occurred between the sixth and beginning of the fifth millennium BCE. Significant craniodental morphological differences remain inadequately tested by biometric analyses of ancestry and may reflect population origins or diet change between the last hunter-fisher-gatherers (Mesolithic) and first food-producers (Neolithic). Moreover, with no anci...
• ETV5 reduces androgen receptor expression and induces neural stem-like properties during neuroendocrine prostate cancer development AI翻译
  作者：Lee, Jongeun; Park, Jiho; Hur, Yunjung; Um, Dahun; Choi, Hyung-Seok; Park, Joonyoung; Kim, Yewon; Lee, Jeon-Soo; Choi, Kyuha; Kim, Eunjeong; Park, Young Bin; Choi, Jae-Mun; Kim, Tae-Kyung; Lee, Yoontae
  作者单位：Pohang University of Science & Technology (POSTECH); Kyungpook National University (KNU); Chungnam National University; Korea University; Yonsei University
  摘要：Neuroendocrine prostate cancer (NEPC), an aggressive subtype induced by hormone therapy, lacks effective treatments. This study explored the role of E26 transformation-specific variant 5 (ETV5) in NEPC development. Analysis of multiple prostate cancer datasets revealed that NEPC is characterized by significantly elevated ETV5 expression compared to other subtypes. ETV5 expression increased progressively under hormone therapy through epigenetic modifications. ETV5 induced neural stem-like featu...
• ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis-induced macrophage death AI翻译
  作者：Yang, Ziwei; Zhang, Li; Ottavi, Samantha; Geri, Jacob B.; Perkowski, Andrew; Jiang, Xiuju; Pfau, Daniel; Bryk, Ruslana; Aube, Jeffrey; Zimmerman, Matthew; Dartois, Veronique; Nathan, Carl
  作者单位：Cornell University; Weill Cornell Medicine; Southern University of Science & Technology; University of North Carolina; University of North Carolina Chapel Hill; Cornell University; Weill Cornell Medicine
  摘要：Mycobacterium tuberculosis (Mtb) primarily infects macrophages. In vitro without antibiotics, wild-type Mtb hastens death of the macrophages, but the processes leading to rapid cell death are not well understood. Our earlier work indicated that the death of Mtb-infected mouse macrophages in vitro is markedly exacerbated by induction of interferon-f3 (IFN-f3) [L. Zhang et al.,J. Exp. Med. 18, e20200887 (2021)]. Here, we identified a key downstream response to IFN-f3 in the context of Mtb infect...
• Cell extrusion drives neural crest cell delamination AI翻译
  作者：Zajic, Emma L. Moore; Zhao, Ruonan; McKinney, Mary C.; Yi, Kexi; Wood, Christopher; Trainor, Paul A.
  作者单位：Stowers Institute for Medical Research; University of Kansas; University of Kansas Medical Center
  摘要：Neural crest cells (NCC) comprise a heterogeneous population of cells with variable potency that contribute to nearly every tissue and organ throughout the body. Considered unique to vertebrates, NCC are transiently generated within the dorsolateral region of the neural plate or neural tube during neurulation. Their delamination and migration are crucial for embryo development as NCC differentiation is influenced by their final resting locations. Previous work in avian and aquatic species reve...
• Immobile lipopolysaccharides and outer membrane proteins differentially segregate in growing Escherichia coli AI翻译
  作者：Kumar, Sandip; Inns, Patrick G.; Ward, Scott; Lagage, Valentine; Wang, Jingyu; Kaminska, Renata; Booth, Martin J.; Uphoff, Stephan; Cohen, Edward A. K.; Mamou, Gideon; Kleanthous, Colin
  作者单位：University of Oxford; Imperial College London; University of Oxford; Hebrew University of Jerusalem
  摘要：The outer membrane (OM) of gram-negative bacteria is a robust, impermeable barrier that excludes many classes of antibiotics. Contrary to the classical model of an asymmetric lipid bilayer, recent evidence suggests the OM is predominantly an asymmetric integral beta-barrel outer membrane proteins (OMPs) are shared with other OMPs to form a supramolecular network in which the levels of OMPs approach those of LPS. Some of the most abundant OMPs in the Escherichia coli OM are trimeric porins. How...
• Evolution of the JULGI-SMXL4/5 module for phloem development in angiosperms AI翻译
  作者：Park, Chanyoung; Cho, Hyun Seob; Lim, Yookyung; Cho, Chung Hyun; Nam, Hoyoung; Choi, Sangkyu; Lim, Hojun; Kim, Young - Dong; Yoon, Hwan Su; Cho, Hyunwoo; Hwang, Ildoo
  作者单位：Pohang University of Science & Technology (POSTECH); Chungbuk National University; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI); Hallym University; Sungkyunkwan University (SKKU)
  摘要：Bifacial cambium, which produces xylem and phloem, and monopodial architecture, characterized by apical dominance and lateral branching from axillary buds, are key developmental features of seed plants, consisting of angiosperms and gymnosperms. These allow seed plants to adapt to diverse environments by optimizing resource allocation and structural integrity. In seed plants, SUPPRESSOR OFMAX2-LIKE (SMXL) family members function in phloem development and strigolactone-induced inhibition of axi...
• HCV NS3/4A protease relocalizes CCTα to viral replication sites, enhancing phosphatidylcholine synthesis and viral replication AI翻译
  作者：Sarwar, Shamila; Randall, Glenn
  作者单位：University of Chicago
  摘要：Positive-sense single-stranded RNA [(+)RNA] viruses constitute more than one-third of all virus genera, including numerous pathogens of clinical significance. All (+)RNA viruses reorganize cellular membranes from organelles to establish replication compartments (RCs). These RCs are thought to form a platform for membrane-associated replicases, in addition to protecting the viral RNAs from cytosolic innate immune signaling and RNA-degradation machinery.Previous work demonstrated that three fami...