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作者：Xu, Xi; V. Zuza, Andrew; Liu, Lijun; Zhu, Weilin; Sun, Yanyun; Wang, Baodi; Kuang, Xingtao; Han, Song; Zhang, Xuanjie; Zhang, Wan; Fu, Xiaowei; Pearson, D. Graham; Liu, Jingao
作者单位：Yangtze University; Yangtze University; China Geological Survey; Tongji University; Nevada System of Higher Education (NSHE); University of Nevada Reno; Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS; China National Offshore Oil Corporation (CNOOC); University of Alberta; China University of Geosciences; China University of Geosciences
摘要：The evolution of continents is shaped by the growth and destruction of long-lived cratons, which serve as their stable cores. Processes for craton destruction are controversial because most invoked mechanisms occur frequently throughout Earth history, making the preservation of cratons for billions of years problematic. Here, we address this issue by presenting a crustal-scale analytical signal-amplitude model obtained from high-resolution airborne and shipborne magnetic data across cratons wi...
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作者：Zhou, Nan; Zhang, Yan; Chen, Peng R.; Fan, Xinyuan
作者单位：Peking University; Peking University
摘要：Apoptosis is a critical outcome of stress-induced processes, with the endoplasmic reticulum (ER) playing a central role in apoptotic protein processing and stress signal transduction. Profiling the ER proteome during stress to cell death offers valuable insights into these processes, but existing methods often suffer from a loss of in situ information or requirement of genetic manipulation. In this study, we introduce CAT-ER, a nongenetic ER proteomics system that provides in situ labeling, sp...
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作者：Gardella, Anne E.; Eweis-LaBolle, Daniel; Loy, Conor J.; Belcher, Emma D.; Lenz, Joan S.; Franconi, Carl J.; Scofield, Sally Y.; Grimson, Andrew; Hanson, Maureen R.; De Vlaminck, Iwijn
作者单位：Cornell University; Cornell University
摘要：People living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience heterogeneous and debilitating symptoms that lack sufficient biological explanation, compounded by the absence of accurate, noninvasive diagnostic tools. To address these challenges, we explored circulating cell-free RNA (cfRNA) as a blood-borne bioanalyte to monitor ME/CFS. cfRNA is released into the bloodstream during cellular turnover and reflects dynamic changes in gene expression, cellular signaling,...
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作者：Luo, Geyang; Wen, Yanling; Wang, Min; Wang, Hao; Li, Duoduo; Liao, Mingfeng; Zeng, Dong; Luo, Sizhu; Niu, Liangfei; Sun, Tao; Sun, Peng; Qin, Liyi; Li, Weimin; Song, Shu; Takiff, Howard E.; Zhang, Shuye; Gao, Qian; Zhang, Zheng; Yan, Bo
作者单位：Fudan University; Southern University of Science & Technology; Fudan University; Fudan University; Capital Medical University; Venezuelan Institute Science Research; Fudan University; The Third People's Hospital of Shenzhen
摘要：Granulomas play a crucial role in the pathology of tuberculosis, but the immune environment governing their formation remains largely unknown. To explore the dynamic changes in the immune microenvironment during the formation of tuberculous granulomas, we infected adult zebrafish with Mycobacterium marinum and then examined uninfected and infected kidneys, as well as large and small granulomas in the kidneys. Using single-cell RNA sequencing technology, we identified two major macrophage subpo...
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作者：Sakurai, Yuya; Fujioka, Yoichiro; Maishi, Nako; Takeda, Ryo; Ohba, Yusuke; Sasaki, Michihito; Teshirogi, Takahito; Ito, Wataru; Hida, Yasuhiro; Matsuda, Aya; Kido, Kanta; Orba, Yasuko; Sawa, Hirofumi; Hida, Kyoko
作者单位：Hokkaido University; Hokkaido University; Hokkaido University; Hokkaido University; Hokkaido University; Hokkaido University; Hokkaido University; Hokkaido University; Fujita Health University; Fujita Health University; Hokkaido University
摘要：Aging is a risk factor for severe COVID-19, characterized by vascular endothelial dysfunction. Although possible susceptibility of vascular endothelial cells (ECs) to SARS-CoV-2 infection has been suggested, the details of entry into cells have not been clarified. Previously, we reported that in an aged mouse model of severe COVID-19, ECs show a massive viral uptake and inflammatory response. Here, we focused on the endocytic capacity of senescent ECs. We found that the senescent ECs showed hi...
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作者：Anand, Uttam; Patra, Shubhadeep; Sekar, Rohith Vedhthaanth; Garen, Craig R.; Woodside, Michael T.
作者单位：University of Alberta; University of Alberta; University of Alberta
摘要：Misfolding of the protein PrP causes prion diseases in mammals. Disease susceptibility varies widely among species, despite PrP sequences differing by only a few amino acids. How these differences alter PrP folding and misfolding remains unclear. We compared the folding dynamics of single PrP molecules from three species with different disease susceptibility: dogs (immune), hamsters (susceptible), and bank voles (extremely susceptible). Measurements with optical tweezers revealed important dif...
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作者：Leahy, Lily; Chown, Steven L.; Riskas, Hannah L.; Wright, Ian J.; Carlesso, Amelia G.; Hammer, Ian J.; Sanders, Nathan J.; Bishop, Tom R.; Parr, Catherine L.; Gibb, Heloise
作者单位：La Trobe University; Monash University; Western Sydney University; Macquarie University; Deakin University; University of Melbourne; University of Michigan System; University of Michigan; Cardiff University; University of Pretoria; University of Liverpool; University of New South Wales Sydney
摘要：Metabolic rate dictates life's tempo, yet how ecological and environmental factors integrate to shape metabolic traits remains contentious. Considering metabolic traits of 114 species of ants from seven subfamily clades along a 1,500 km climatic and soil phosphorus availability gradient in Australia, we tested four hypotheses relating to variation in metabolic rate due to niche conservatism, temperature, aridity, and ecological stoichiometry. We also tested the contested hygric hypothesis, whi...
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作者：Lena, Anna Maria; Smirnov, Artem; Mancini, Mara; Montanaro, Manuela; Ciccosanti, Fabiola; Foti, Valeria; Nardacci, Roberta; Fimia, Gian Maria; Mavilio, Mara; Federici, Massimo; Mauriello, Alessandro; Piacentini, Mauro; Melino, Gerry; Candi, Eleonora
作者单位：University of Rome Tor Vergata; University of Rome Tor Vergata
摘要：The transcription factor p63 is an essential regulator of epithelial development. Yet, the complexity at the 3 ' UTR, which gives rise to the three distinct C-terminal protein isoforms (alpha, f3, and gamma), remains unresolved and opens an investigation on the in vivo role of the C-terminus. This region, codified by exon 13, harbors genetic mutations leading to AEC syndrome. Here, we generated a mouse with a deletion of p63 exon 13 in keratin-14-expressing tissues and employed transcriptome, ...
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作者：Nelson, Melissa K.; Reed, Graeme
作者单位：Arizona State University; Arizona State University-Tempe; York University - Canada
摘要：Indigenous peoples have long histories and diverse contemporary practices of caring for and enhancing biodiversity at different scales, in rural and urban contexts. As has been researched and documented by the Convention on Biological Diversity and others, Indigenous peoples globally only constitute 5% of the world's population and control and care for just 20% of the Earth's surface yet protect nearly 80% of the world's remaining biodiversity. Indigenous peoples have forms of biodiversity con...
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作者：Holland, Patrick L.
作者单位：Yale University
