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作者：Muramatsu, David; Weyer, Henrik; Gartner, Florian M.; Frey, Erwin
作者单位：University of Munich; University of Munich
摘要：The thymus is one of the most important organs of the immune system. It is responsible for both the production of T cells and the prevention of their autoimmunity. It comprises two types of tissue: The cortex, where nascent T cells (thymocytes) are generated; and the medulla, embedded within the cortex, where autoreactive thymocytes are eliminated through negative selection. In mice, the medulla exhibits a complex, convoluted morphology, which has raised the question of whether its form impact...
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作者：Ren, Xiaojun; Sui, Xiao; Karton, Amir; Nishina, Yuta; Lin, Tongxi; Asanoma, Daisuke; Owens, Llewellyn; Ji, Dali; Wen, Xinyue; Quintano, Vanesa; Tripathi, Komal; Pant, Kamal K.; Dai, Liming; Andreeva, Daria, V; Foller, Tobias; Novoselov, Kostya S.; Joshi, Rakesh
作者单位：University of New South Wales Sydney; Harbin Institute of Technology; University of New England; Okayama University; Institute for Functional Intelligent Materials (I-FIM); National University of Singapore; Consejo Superior de Investigaciones Cientificas (CSIC); Barcelona Institute of Science & Technology; Catalan Institute of Nanoscience & Nanotechnology (ICN2); Barcelona Institute of Science & Technology; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Roorkee; University of New South Wales Sydney; National University of Singapore
摘要：Water molecules at the solid-liquid interface display intricate behaviors sensitive to small changes. The presence of different interfacial components, such as cations or functional groups, shapes the physical and chemical properties of the hydrogen-bond network. Understanding such interfacial hydrogen-bond networks is essential for a large range of applications and scientific questions. To probe the interfacial hydrogen-bond network, atmospheric water capture is a powerful tool. Here, we expe...
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作者：Fan, Zhao; Rawat, Deepak; Zarzycki, Piotr; Whittaker, Michael L.; Asta, Mark
作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Despite over a century of studies, fundamental questions remain about the processes governing crystal nucleation from melts or solutions. Research over the past three decades has presented mounting evidence for kinetic pathways of crystal nucleation that are more complex than envisioned by the simplest forms of classical theory. Such observations have been presented for colloidal and elemental systems with covalent and metallic bonding. Despite the technological and geochemical importance of m...
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作者：Pradhan, Arnab; Nev, Olga A.; Leaves, Ian; Nev, Oleg A.; Ma, Qinxi; Milne, Gillian; Patterson, Grace; Netea, Mihai G.; Erwig, Lars P.; Farrer, Rhys A.; Brown, Gordon D.; van den Berg, Hugo A.; Gow, Neil A. R.; Brown, Alistair J. P.
作者单位：UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Exeter; University of Aberdeen; University of Exeter; Radboud University Nijmegen; Radboud University Nijmegen; University of Bonn; Cancer Research UK; University of Warwick
摘要：Fungal pathogens infect billions and kill millions of people each year. Many of these pathogens have evolved strategies to evade our antifungal immune defenses. Candida albicans, for example, masks the proinflammatory pathogen-associated molecular pattern (PAMP) beta-1,3-glucan, in response to specific host signals such as lactate. In C. albicans, most beta-1,3-glucan lies in the inner cell wall shielded, by the outer mannan layer, from recognition by certain immune cells such as macrophages. ...
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作者：Kuznets-Speck, Benjamin; Ogonor, Buduka K.; Wytock, Thomas P.; Motter, Adilson E.
作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University
摘要：The relationship between genotype and phenotype remains an outstanding question for organism-level traits because these traits are generally complex. The challenge arises from complex traits being determined by a combination of multiple genes (or loci), which leads to an explosion of possible genotype-phenotype mappings. The primary techniques to resolve these mappings are genome/transcriptome-wide association studies, which are limited by their lack of causal inference and statistical power. ...
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作者：Gonzalez-Magaldi, Monica; Gullapalli, Anuradha; Papoulas, Ophelia; Liu, Chang; Leung, Adelaide Y. -H.; Guo, Luqiang; Brilot, Axel F.; Marcotte, Edward M.; Ke, Zunlong; Leahy, Daniel J.
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：We report here transport of full-length epidermal growth factor receptor (EGFR), Insulin Receptor, 7-pass transmembrane receptor Smoothened, and 13-pass Sodium-iodide symporter to extracellular vesicles (EVs) for structural and functional studies. Mass spectrometry confirmed the transported proteins are the most abundant in EV membranes, and the presence of many receptor-interacting proteins in EVs demonstrates their utility for characterizing membrane protein interactomes. Cryo-electron tomog...
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作者：Gustavson, Daniel E.; Borriello, Giulia A.; Karhadkar, Mohini A.; Rhee, Soo Hyun; Corley, Robin P.; Rhea, Sally-Ann; DiLalla, Lisabeth F.; Wadsworth, Sally J.; Friedman, Naomi P.; Reynolds, Chandra A.
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent; Southern Illinois University System; Southern Illinois University
摘要：Measures of general cognitive ability (GCA) are highly stable from adolescence onward, particularly at the level of genetic influences. In contrast, measurement of GCA in early life (before 3 y old) is less reliable and less is known about the stability of GCA across this period, including its relation to adult GCA. Using data from the Colorado Longitudinal Twin study (N = 1,098), we examined the stability of GCA measures across 5 time-points (years 1 to 2, 3, 7, 16, and 29), including how an ...
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作者：Juna, Dong-Jae; Schumacher, Marc M.; Joa, Youngah; Faulkner, Rebecca A.; Yang, Yangyang; Tsien, Jet; Qin, Tian; DeBose-Boyd, Russell A.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Dallas Baptist University
摘要：Schnyder corneal dystrophy (SCD) is a rare autosomal dominant condition characterized by the opacification of the cornea owing to the abnormal deposition of cholesterol. SCD-associated mutations have been identified in the gene encoding UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4 (MK-4). Beyond its enzymatic role, UBIAD1 serves as a key regulator of the endoplasmic reticulum (ER)-...
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作者：Pacella, Gina N.; Kuprasertkul, Nina; Bao, Lydia; Huang, Sijia; D'souza, Carina; Prouty, Stephen M.; Anderson, Amy; Lopez, Alexandra M. Maldonado; Sinkfield, Morgan; Olingou, Cyria; Seykora, John T.; Capell, Brian C.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：The X-linked histone demethylase, UTX (KDM6A), is a master regulator of gene enhancers, though its role in self-renewing epithelia like the skin is not well understood. Here, we find that UTX is a key regulator of skin differentiation via the regulation of retinoic acid (RA) signaling, an essential metabolic pathway in both skin homeostasis, as well as in the treatment of an array of skin conditions ranging from cancer and acne to aging. Through deletion of Utx in the skin, we demonstrate dire...
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作者：Wang, Jun; Liao, Long; Yang, Bo; Miao, Beiping; Bernards, Rene; Qin, Wenxin; Sun, Chong; Wang, Cun
作者单位：Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Helmholtz Association; German Cancer Research Center (DKFZ); Netherlands Cancer Institute
