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作者：Liu, Ying; Kendall, John Michael; Zhang, Haijiang; Blundy, Jonathan D.; Pritchard, Matthew E.; Hudson, Thomas; MacQueen, Patricia
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University of Oxford; Cornell University; Swiss Federal Institutes of Technology Domain; ETH Zurich; United States Department of the Interior; United States Geological Survey
摘要：For a volcanic system, evaluating potential eruption probability requires understanding the extent of melt and gas accumulation in the upper crustal reservoir, which is challenging to resolve. Here, we jointly use geophysical imaging and petrophysical analysis to unravel the current state and pathway of gas or supercritical fluids in the upper crust beneath Uturuncu volcano in Bolivia. Although it last erupted 250 +/- 5 ka ago, Uturuncu remains active with observable deformation and seismicity...
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作者：Cao, Yang; Chen, Yanbo; Liu, Weiwei
作者单位：Wuhan University; Wuhan University; Wuhan University; Wuhan University
摘要：Neural collapse (NC) reveals that the last layer of the network can capture data representations, leading to similar outputs for examples within the same class, while outputs for examples from different classes form a simplex equiangular tight frame (ETF) structure. This phenomenon has garnered significant attention due to its implications on the intrinsic properties of neural networks. Interestingly, we observe a simplex compression phenomenon in NC, where the geometric size of the simplex ET...
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作者：Chen, Yu-Fei; Zhang, Qing-Hua; Zhang, Zhong-Wei; Zhou, Yu-Jie; Liu, Cui-Cui; Shao, Zhi-Ming; Yu, Ke-Da
作者单位：Fudan University; Fudan University; Fudan University
摘要：Antibody-drug conjugates (ADCs) are a rapidly developing therapeutic approach in cancer treatment that has shown remarkable efficacy in breast cancer. Despite the promising efficacy of anti-HER2 ADCs, many patients are still experiencing disease progression under treatment. Here, by analyzing the transcriptome data from patient-derived organoid models, I-SPY2 trial, and resistant cell lines, we identified that SNX10 deficiency conferred anti-HER2 ADCs resistance in HER2-positive breast cancer....
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作者：Hatori, Sena; Yamaguchi, Sho T.; Kobayashi, Riho; Okamoto, Kazuki; Zhou, Zhiwen; Kotake, Koki T.; Matsui, Futaba; Hioki, Hiroyuki; Norimoto, Hiroaki
作者单位：Nagoya University; Hokkaido University; Juntendo University
摘要：Slow-wave sleep (SWS) and rapid eye movement sleep are the two primary components of electrophysiological sleep (e-sleep) in mammals and birds. Slow waves in the cortex not only characterize SWS but are also used as biological markers for sleep homeostasis, given their rebound after sleep deprivation (SD). Recently, it has been reported that the Australian dragon Pogona vitticeps exhibits a two-stage sleep pattern in the dorsal ventricular ridge (DVR), which includes a homologue of the mammali...
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作者：Moreno-Spiegelberg, Pablo; Rietkerk, Max; Gomila, Damia
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作者：Sahi, Chandan; Craig, Elizabeth Anne
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作者：Boccalini, Matteo; Berezovska, Yelyzaveta; Bussi, Giovanni; Paloni, Matteo; Barducci, Alessandro
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); International School for Advanced Studies (SISSA); University of London; University College London
摘要：Biomolecular condensates are currently recognized to play a key role in organizing cellular space and in orchestrating biochemical processes. Despite an increasing interest in characterizing their internal organization at the molecular scale, not much is known about how the densely crowded environment within these condensates affects the structural properties of recruited macromolecules. Here, we adopted explicit-solvent all-atom simulations based on a combination of enhanced sampling approach...
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作者：Spencer, Norman R.; Gunabalasingam, Mathusan; Dial, Keshav; Di, Xiaxia; Malcolm, Tonya; Magarvey, Nathan A.
作者单位：McMaster University
摘要：The study of bacterial metabolism holds immense significance for improving human health and advancing agricultural practices. The prospective applications of genomically encoded bacterial metabolism present a compelling opportunity, particularly in the light of the rapid expansion of genomic sequencing data. Current metabolic inference tools face challenges in scaling with large datasets, leading to increased computational demands, and often exhibit limited inter-relatability and interoperabil...
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作者：Khishigsuren, Temuulen; Regier, Terry; Vylomova, Ekaterina; Kemp, Charles
作者单位：University of Melbourne; University of California System; University of California Berkeley; University of Melbourne
摘要：Claims about lexical elaboration (e.g. Mongolian has many horse-related terms) are widespread in the scholarly and popular literature. Here, we show that computational analyses of bilingual dictionaries can be used to test claims about lexical elaboration at scale. We validate our approach by introducing BILA, a dataset including 1,574 bilingual dictionaries, and showing that it confirms 147 out of 163 previous claims from the literature. We then identify previously unreported examples of lexi...
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作者：Lopes, Emily M.; Akizawa, Hiroki; Koc, Oguz C.; Soto-Moreno, Edgar; Gupta, Neha; Ardestani, Goli; Balboula, Ahmed Z.; Carvacho, Ingrid; Fissore, Rafael A.
作者单位：University of Massachusetts System; University of Massachusetts Amherst; University of Massachusetts System; University of Massachusetts Amherst; University of Pennsylvania; University of Missouri System; University of Missouri Columbia; Universidad Catolica del Maule
摘要：Zinc (Zn2+) homeostasis is essential for gametogenesis and reproduction, and its deficiency causes infertility. Oocytes contain higher Zn2+ levels than somatic cells, and Zn2+ concentrations in oocytes are far higher than those of other transition metals and increase even more during maturation in preparation for fertilization. Remarkably, it is unknown what transporter(s) or channel(s) mediate Zn2+ influx in oocytes and whether they are expressed uniformly throughout folliculogenesis. Here, w...
