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作者：Hwang, Gayoung; Yang, Dae-Wook; Geisseova, Terezia Klaudia; Kim, Hae A.; Oh, Yangkyun; Suh, Greg S. B.
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Ulsan National Institute of Science & Technology (UNIST); Korea Advanced Institute of Science & Technology (KAIST); Ewha Womans University
摘要：In an ever- changing environment, animals make optimal decisions to ensure their nutrients they require to maintain homeostasis. Under extreme circumstances (e.g., infection), they may exhibit ingestive behaviors, such as seeking out substances (e.g., toxins) that suggest self- medication. Few studies, however, have investigated the mechanisms that ensue self- medication. Here, we report the selective intake of antioxidants by Drosophila melanogaster during a period of heat stress or sleep dep...
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作者：Lynch, Elizabeth A.; Calcote, Randy; Zabinski, Catherine A.; Hotchkiss, Sara C.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; Montana State University System; Montana State University Bozeman; University of Wisconsin System; University of Wisconsin Madison
摘要：Margaret Bryan Davis, a prominent ecologist, died on May 22, 2024. She was a Regents Professor at the University of Minnesota and a member of the National Academy of Sciences. Her students remember her as a creative and clear-thinking scientist who combined the tools and perspectives of paleoecology with ideas and problems of ecology in order to understand long-term forest dynamics. She was a champion of diversity and equity in science.
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作者：Saglimbeni, Joseph; Esteva, Eduardo; Canales, Josue; Perez, Oriana A.; Eichinger, Anna; Huntley, William; Khanna, Kamal M.; Dolgalev, Igor; Klar, Natalie; Adams, Sylvia; Reizis, Boris
作者单位：New York University; New York University; New York University; University of Munich; New York University; New York University
摘要：Breast tumors harbor dynamic microenvironments, with multiple immune cell types playing opposing roles during tumor progression and/or response to therapy. Tumor- associated macrophages promote mammary tumorigenesis, whereas the role of mammary tissue macrophages (MTMs) remains incompletely understood. High- dimensional immunostaining of murine mammary tumor progression revealed that MTMs were localized in the peritumoral stroma and associated with eosinophils, which were previously shown to f...
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作者：Daniotti, Simone; Hartog, Matte; Neffke, Frank
作者单位：Technische Universitat Wien; Utrecht University; Harvard University
摘要：Diversified economies are critical for cities to sustain their growth and development, but they are also costly because diversification often requires expanding a city's capability base. We analyze how cities manage this trade-off by measuring the coherence of the economic activities they support, defined as the technological distance between randomly sampled productive units in a city. We use this framework to study how the US urban system developed over almost two centuries, from 1850 to tod...
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作者：Stidsholt, Laura; Zebele, Mara; Scholz, Carolin; Voigt, Christian C.
作者单位：Leibniz Institut fur Zoo und Wildtierforschung; Aarhus University; University of Potsdam
摘要：Animals can improve their decision-making abilities by integrating information from multiple senses, which is especially beneficial when living in fluctuating environments. However, understanding how wild predators may use multimodal sensing when hunting prey in split-second interactions remains largely unexplored. As nocturnal hunters, bats rely on echolocation to navigate and to locate evasive prey, yet they have retained functional vision, despite the associated costs. We therefore hypothes...
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作者：Wang, Jiaojiao; Zhou, Chunhong; Zhuang, Kai; Zou, Jiami; Qiu, Wanlu; Jin, Mei; Ye, Weile; Yang, Pinglian; Zheng, Zhihua; Zhou, Qing; Huang, Zunnan; Wang, Yuanxiang; Liu, Peiqing; Lu, Jing; Huo, Yuqing; Liu, Zhiping
作者单位：Jinan University; Guangdong Medical University; Guangdong Medical University; Jinan University; Sun Yat Sen University; Sun Yat Sen University; Baylor College of Medicine
摘要：Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell-mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an enrichment of sorting nexin (SNX)-related pathways, with SNX3, a member of the SNX family that is involved in endosomal sorting and trafficking, being significantly upregulated in the myeloid cell subp...
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作者：Xiang, Bingbing; Deng, Chaoyi; Yang, Han; Zhang, Wensheng
作者单位：Sichuan University; Sichuan University
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作者：Gaffney, Anna D.; Liu, Dongxu; Samal, Deepanjali; Carotenuto, Angelo R.; Deseri, Luca; Fraldi, Massimiliano; Lee, Ka Yee C.; Pocivavsek, Luka; Nguyen, Nhung
作者单位：University of Chicago; University of Chicago; University of Naples Federico II; University of Trento; Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Cite; University of Chicago; University of Chicago
摘要：Self-assembled thin films respond to external loads via surface instabilities that are critical to their functionality in both biology and technology. Lipid monolayers at the air-liquid interface are one such system. Tunability between out-of-plane buckling (e.g., folding) and in-plane relaxation (e.g., reorganization of lipid domains) in highly compressed lipid monolayers suggests underlying mechanistic generality. Yet, how in-plane relaxation occurs and how it is distinguished from folding r...
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作者：Sinclair, Alyssa H.; Cosme, Danielle; Lydic, Kirsten; Reinero, Diego A.; Mann, Michael E.; Falk, Emily B.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
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作者：Wang, Erin R.; Cho, Kevin; Harrison, Gregory A.; Smelyansky, Stephanie R.; Soni, Vijay; Smirnov, Asya; Mckee, Samuel R.; Ghabrial, George S.; Flentie, Kelly N.; Beatty, Wandy; Anyinam, Boatema Ofori -; Sarkar, Souvik; Hurtaux, Thomas; Loza, Liza; Almqvist, Fredrik; Doering, Tamara L.; Yang, Jason H.; Kiessling, Laura L.; Rhee, Kyu Y.; Patti, Gary J.; Stallings, Christina L.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Ragon Institute; Cornell University; Weill Cornell Medicine; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Umea University; Umea University; University of Wisconsin System; University of Wisconsin Madison
摘要：Isoniazid (INH) inhibits mycolic acid synthesis in Mycobacterium tuberculosis (Mtb) and is a cornerstone of treatment regimens against this deadly pathogen. However, over 10% of Mtb infections are INH-resistant. The compound C10 can sensitize clinically relevant INH-resistant mutants to killing by INH. Thus, understanding the mechanism of action for C10 could aid in designing new strategies for circumventing drug resistance. We find that C10 treatment reroutes carbon flux toward valine, drawin...
