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作者：Wang, Yu
作者单位：Fudan University
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作者：Wang, Binhang; Sun, Libo; Wang, Tong; Cao, Yujie; Li, Xiang; Xu, Wenhao; Zhang, Jie; Tang, Yun
作者单位：Fudan University
摘要：Ordered mesoporous Metal-Organic Frameworks (mesoMOFs), integrating mesopores and micropores, address mass transfer limitations characteristic of microporous materials, thus broadening their application spectrum. However, the synthesis of mesoMOFs has been predominantly achievable in aqueous media, rather than in organic solvents, which are more conducive to the growth and stabilization of MOFs. This is primarily attributed to the challenge in forming stable and uniform micelles from block cop...
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作者：Wang, Xiaohan; Liu, Mengyao; Zhang, Yifan; Ma, Dongyuan; Wang, Lu; Liu, Feng
作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beijing Institute for Stem Cell & Regenerative Medicine; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Shandong University
摘要：During fetal stage, hematopoietic stem and progenitor cells (HSPCs) undergo rapid proliferation with a tight control of genomic stability. Although histone H3 lysine 4 (H3K4) methylation has been reported to stabilize the genome in proliferating cells, its specific role in HSPC development remains elusive. In this study, we demonstrated that tryptophan-aspartic acid (WD) repeat protein 5 (Wdr5)- mediated H3K4 methylation is crucial for maintaining genomic stability of proliferating HSPCs in ze...
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作者：Crabtree, Charles
作者单位：Dartmouth College
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作者：Yan, Gaoge; Amita, Hidetoshi; Nonomura, Satoshi; Inoue, Ken-ichi; Schultz, Wolfram; Takada, Masahiko
作者单位：Kyoto University; Shiga University of Medical Science; University of Cambridge
摘要：Dopamine (DA) signals to the striatum play critical roles in shaping and sustaining stimulus-reward associations. In primates, however, the dynamics of the DA signals remain unknown since conventional methods are not necessarily appropriate in terms of the spatiotemporal resolution or chemical specificity sufficient for detecting the DA signals. In our study, fiber photometry with a fluorescent DA sensor was employed to identify reward-related DA transients in the monkey striatum. This techniq...
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作者：Huang, Ziyu; Dong, Chuanfei; Wang, Liang
作者单位：Boston University
摘要：Nonlinear plasma physics problems are usually simulated through comprehensive modeling of phase space. The extreme computational cost of such simulations has motivated the development of multi-moment fluid models. However, a major challenge has been finding a suitable fluid closure for these fluid models. Recent developments in physics-informed machine learning have led to a renewed interest in constructing accurate fluid closure terms. In this study, we take an approach that integrates kineti...
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作者：Eggertsen, Taylor G.; Travers, Joshua G.; Hardy, Elizabeth J.; Wolf, Matthew J.; McKinsey, Timothy A.; Saucerman, Jeffrey J.
作者单位：University of Virginia; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Virginia
摘要：Cardiomyocyte hypertrophy is a key clinical predictor of heart failure. High-throughput and AI-driven screens have the potential to identify drugs and downstream pathways that modulate cardiomyocyte hypertrophy. Here, we developed LogiRx, a logic-based mechanistic machine learning method that predicts drug-induced pathways. applied LogiRx to discover how drugs discovered in a previous compound screen attenuate cardiomyocyte hypertrophy. We experimentally validated LogiRx predictions in neonata...
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作者：He, Ling; Azizad, Daria; Bhat, Kruttika; Ioannidis, Angeliki; Hoffmann, Carter J.; Arambula, Evelyn; Eghbali, Mansoureh; Bhaduri, Aparna; Kornblum, Harley I.; Pajonk, Frank
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Glioblastoma (GBM) is the deadliest brain cancer in adults, and all patients succumb to the tumor. While surgery followed by chemoradiotherapy delays disease progression, these treatments do not lead to tumor control, and targeted therapies or biologics have failed to further improve survival. Utilizing a transient radiation- induced state of multipotency, we used the adenylcyclase activator forskolin to alter the fate of irradiated glioma cells. The effects of the combined treatment on neuron...
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作者：Usdin, Karen
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
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作者：Huang, Han-Wen; Zeng, Yi-Fang; Shivatare, Vidya S.; Tseng, Tzu-Hao; Wong, Chi-Huey
作者单位：Scripps Research Institute
摘要：Glycosylation of humanized antibody at Fc- Asn297 significantly affects the Fc- mediated killing of target cells through effector functions, especially antibody- dependent cellular cytotoxicity (ADCC), antibody- dependent cell- mediated phagocytosis (ADCP), and antibody- dependent vaccinal effect (ADVE). Previous studies showed that therapeutic immunoglobulin G (IgG) antibodies with alpha 2,6- sialyl complex type (SCT) glycan attached to Fc- Asn297 exhibited optimal binding to the Fc receptors...
