Proceedings of the National Academy of Sciences of the United States of America

最新文章

• A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics AI翻译
  作者：Hoeppner, Jakob; Firat, Damla; Parvez-Khan, Mohd; Reyes, Monica; Hanna, Patrick; Yadav, Prem Swaroop; Dean, Thomas; Ramos-Torres, Karla M.; Brugarolas, Pedro; Collins, Michael T.; Wein, Marc N.; Liu, Shi; Gellman, Samuel H.; Schipani, Ernestina; Kronenberg, Henry M.; Gardella, Thomas J.; Jueppner, Harald
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University of Duisburg Essen; University of Pennsylvania; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); University of Wisconsin System; University of Wisconsin Madison; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; National University of Singapore
  摘要：Jansen's metaphyseal chondrodysplasia (JMC) is a rare disorder caused by activating mutations in the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTH1R). Patients exhibit short stature, dysmorphic bones, and severe growth plate abnormalities, as well as hypercalcemia, hypercalciuria, hypophosphatemia, and reduced plasma PTH levels. Humanized PTH1R (hPTH1R) mice expressing the H223R-hPTH1R JMC mutation die early without breeding. We therefore generated and characterized a sta...
• Multiphasic size-dependent growth dynamics of nanoparticle ensembles AI翻译
  作者：Kim, Ji- Hyun; Kim, Joodeok; Kim, Byung Hyo; Song, Sanggeun; Kang, Jingyu; Rhee, Jinho; Kim, Donghee; Chun, Hoje; Choi, Hyesung; Cho, Hyungjin; Kim, Yongjoon; Jung, Jae Won; Son, Youngju; Jung, Junhyeok; Park, Kunwoo; Jeon, Sungho; Lee, Minho; Han, Byungchan; Lee, Won Chul; Kim, Dongjun; Hyeon, Taeghwan; Sung, Jaeyoung; Park, Jungwon
  作者单位：Chung Ang University; Chung Ang University; Chung Ang University; Institute for Basic Science - Korea (IBS); Seoul National University (SNU); Seoul National University (SNU); Soongsil University; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Chung Ang University; Yonsei University; Hanyang University; Seoul National University (SNU); Seoul National University (SNU)
  摘要：Colloidal nanoparticles are of great interest in modern science and industry. However, the thermodynamic mechanism and dynamics of nanoparticle growth have yet to be understood. Addressing these issues, we tracked hundreds of in-situ growth trajectories of a nanoparticle ensemble using liquid-phase TEM and found that the nanoparticle growth, including coalescence, exhibits nanoparticle size-dependent multiphasic dynamics, unexplainable by current theories. Motivated by this finding, we develop...
• Self- reproduction as an autonomous process of growth and reorganization in fully abiotic, artificial and synthetic cells AI翻译
  作者：Katla, Sai Krishna; Lin, Chenyu; Perez-Mercader, Juan
  作者单位：Harvard University; The Santa Fe Institute
  摘要：We investigate mechanisms for the observed nonlinear growth in the number of polymer vesicles generated during a photo- Reversible Addition- Fragmentation Chain Transfer- based polymerization- induced self- assembly (PISA) reaction. Our experimental results reveal the presence of a self- reproduction process during which chemically active polymer protocells are chemically and autonomously generated in a light- stimulated one- pot reaction that starts from a homogeneous blend of non- self- asse...
• Global patterns of nutrient limitation in soil microorganisms AI翻译
  作者：Cui, Yongxing; Peng, Shushi; Rillig, Matthias C.; Camenzind, Tessa; Delgado-Baquerizo, Manuel; Terrer, Cesar; Xu, Xiaofeng; Feng, Maoyuan; Wang, Mengjie; Fang, Linchuan; Zhu, Biao; Du, Enzai; Moorhead, Daryl L.; Sinsabaugh, Robert L.; Penuelas, Josep; Elser, James J.
  作者单位：Peking University; Free University of Berlin; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); Massachusetts Institute of Technology (MIT); California State University System; San Diego State University; Wuhan University of Technology; Peking University; Peking University; Beijing Normal University; University System of Ohio; University of Toledo; University of New Mexico; Consejo Superior de Investigaciones Cientificas (CSIC); Autonomous University of Barcelona; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); University of Montana System; University of Montana; University of Montana System; University of Montana; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe
  摘要：The availability of nitrogen (N) and phosphorus (P) is essential for soil microbial activity and growth, yet global patterns of N and P limitation in soil microbial metabolism remain largely unknown. We modeled ecoenzyme stoichiometry data from 5,259 field observations of natural ecosystems to assess microbial N and P limitation in global surface soils. We found that microbial P limitation, which was especially strong at low latitudes, was more prevalent globally than microbial N limitation, w...
• Staphylococcus aureus SaeR/S-regulated factors overcome human complement-mediated inhibition of aggregation to evade neutrophil killing AI翻译
  作者：Pettygrove, Brian A.; Nygaard, Tyler K.; Borgogna, Timothy R.; Malachowa, Natalia; Gaur, Gauri; Salo, Shannon E.; Pallister, Kyler B.; Burroughs, Owen; Robinson, Cassandra; Gao, Annika; Sturdevant, Daniel E.; Ricklefs, Stacy; DeLeo, Frank R.; Otto, Michael; Stewart, Philip S.; Voyich, Jovanka M.
  作者单位：Montana State University System; Montana State University Bozeman; Montana State University System; Montana State University Bozeman; National Institutes of Health (NIH) - USA; Division of Intramural Research (DIR); NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Montana State University System; Montana State University Bozeman
  摘要：Staphylococcus aureus (S. aureus) is a frequent culprit in implant-associated infections and employs many virulence factors to escape killing by the host immune system. The specific immune evasion strategies used by small aggregates of S. aureus on a surface, precursors to mature biofilm, are still relatively unknown. Time-lapse confocal microscopy was leveraged to quantify interactions between S. aureus aggregates and human neutrophils in vitro and identify specific mechanisms of resistance t...
• Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant AI翻译
  作者：Yanga, Brenda; Rutkowskia, Natalie; Rutaa, Anna; Gray-Gaillarda, Elise; Maestas Jr, David R.; Kellya, Sean H.; Krishnana, Kavita; Wub, Xinqun; Wub, Shaoguang; Chenc, Allen; Mejias, Joscelyn C.; Hooksa, Joshua S. T.; Vanderzeea, Isabel; Mensaha, Patricia; Celika, Nazmiye; Erica, Marie; Abrahama, Peter; Tamd, Ada; Housseaud, Franck; Pardolld, Drew M.; Sears, Cynthia L.; Elisseeffa, Jennifer H.
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
  摘要：The gut microbiota influences systemic immunity and the function of distal tissues, including the brain, liver, skin, lung, and muscle. However, the role of the gut microbiota in the foreign body response and fibrosis is largely unexplored. To investigate this connection, we perturbed the homeostasis of the murine gut microbiota via infection with the pathogenic bacterial species enterotoxigenic Bacteroides fragilis (ETBF) and implanted particulate material (mean particle size <600 mu m) of th...
• How infants look shapes what they learn AI翻译
  作者：Dekker, Tessa M.; Maimon-Mor, Roni O.
  作者单位：University of London; University College London; University of London; University College London
• Lane formation in criss- crossing crowds AI翻译
  作者：Kroy, Klaus
  作者单位：Leipzig University
• Nonequilibrium relaxation exponentially delays the onset of quantum diffusion AI翻译
  作者：Bhattacharyya, Srijan; Sayer, Thomas; Montoya-Castillo, Andres
  作者单位：University of Colorado System; University of Colorado Boulder; Durham University
  摘要：Predicting the exact many-body quantum dynamics of polarons in materials with strong carrier-phonon interactions presents a fundamental challenge, often necessitating one to adopt approximations that sacrifice the ability to predict the transition from nonequilibrium relaxation to thermodynamic equilibrium. Here, we exploit a recent breakthrough that generalizes the concept of memory beyond its conventional temporal meaning to also encompass space. Specifically, we leverage our finding that th...
• Inheritance of extraordinary metabolic activity from parental bacteria individuals AI翻译
  作者：Lu, Yuyang; Gao, Jia; Xie, Ruo - Chen; Su, Hua; Zhang, Yaoyao; Wang, Wei
  作者单位：Nanjing University; Nanjing University of Chinese Medicine
  摘要：Many phenotypic traits, such as fermentation activity, have been shown to be instable due to stochastic gene expression and environmental influence. While previous studies only have obtained understanding at the level of the microbial community, the fate of extraordinary traits of an individual through generations of reproduction has yet to be adequately investigated. This work uses the lactic acid bacteri Lactiplantibacillus plantarum as a research model to study the activity inheritance betw...