Proceedings of the National Academy of Sciences of the United States of America

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• Reply to Possenriede et al.: LDLR as a targetable HlyA receptor in Escherichia coli pyelonephritis AI翻译
  作者：Kuhn, Hunter W.; Smither, Madeleine R.; Collins, Christina A.; Gaut, Joseph P.; Diamond, Michael S.; Hunstad, David A.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
• LDL receptor promotes urinary tract infection by α- hemolysin-producing Escherichia coli and long-term histopathologic sequelae in the kidney AI翻译
  作者：Possenriede, Lena; Sendtner, Georg W.; Falahat, Peyman; Miranda, Julia; Schmidt, Axel; Ludwig, Kerstin U.; von Vietinghoff, Sibylle
  作者单位：University of Bonn; University of Bonn
• Convergent evolution of NFP- facilitated root nodule symbiosis AI翻译
  作者：Finegan, Christina; Kates, Heather R.; Guralnick, Robert P.; Soltis, Pamela S.; Resende Jr, Marcio F. R.; Ane, Jean-Michel; Kirst, Matias; Folk, Ryan A.; Soltis, Douglas E.
  作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Mississippi State University; State University System of Florida; University of Florida
  摘要：The origin and phylogenetic distribution of symbiotic associations between nodulating angiosperms and nitrogen- fixing bacteria have long intrigued biologists. Recent comparative evolutionary analyses have yielded alternative hypotheses: a multistep pathway of independent gains and losses of root nodule symbiosis vs. a single gain followed by numerous losses. A detailed reconstruction of the history of genes involved in signaling between nitrogen- fixing bacteria and potential hosts, particula...
• Surrogate optimization of variational quantum circuits AI翻译
  作者：Gustafson, Erik J.; Tiihonen, Juha; Chamaki, Diana; Sorourifar, Farshud; Mullinax, J. Wayne; Li, Andy C. Y.; Maciejewski, Filip B.; Sawaya, Nicolas P. D.; Krogel, Jaron T.; Neira, David E. Bernal; Tubman, Norm M.
  作者单位：National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Universities Space Research Association (USRA); University of Jyvaskyla; Columbia University; University System of Ohio; Ohio State University; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; United States Department of Energy (DOE); University of Chicago; Fermi National Accelerator Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Purdue University System; Purdue University; National Aeronautics & Space Administration (NASA); NASA Ames Research Center
  摘要：Variational quantum eigensolvers are touted as a near-term algorithm capable of impacting many applications. However, the potential has not yet been realized, with few claims of quantum advantage and high resource estimates, especially due to the need for optimization in the presence of noise. Finding algorithms and methods to improve convergence is important to accelerate the capabilities of near-term hardware for variational quantum eigensolver or more broad applications of hybrid methods in...
• Using large language models to categorize strategic situations and decipher motivations behind human behaviors AI翻译
  作者：Xie, Yutong; Mei, Qiaozhu; Yuan, Walter; Jackson, Matthew O.
  作者单位：University of Michigan System; University of Michigan; Stanford University; The Santa Fe Institute
  摘要：By varying prompts to a large language model, we can elicit the full range of human behaviors in a variety of different scenarios in classic economic games. By analyzing which prompts elicit which behaviors, we can categorize and compare different strategic situations, which can also help provide insight into what different economic scenarios might induce people to think about. We discuss how this provides a step toward a nonstandard method of inferring (deciphering) the motivations behind the...
• Multistep catalytic abiotic CO2 conversion to sugars through C1 intermediates AI翻译
  作者：Solanda, Nathan; Luoa, Jie; Maulanab, Arifin Luthfi; Feijooa, Julian; Joc, Hye-Jin; Oddoa, Alexander M.; Shanb, Yu; Wanga, Tianle; Leea, Geonhui; Choib, Jihoon; Huynha, Wei-Shan; Guzmana, Maria Fonseca; Jayasinghea, Lihini; Zhub, Cheng; Yanga, Yao; Yanga, Peidong
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Zhejiang University; Seoul National University (SNU); Northwestern University; Cornell University
  摘要：Carbon dioxide (CO2) to multicarbon (Cn) upgrading for commodity chemicals, fuel production, or artificial food synthesis using renewable energy input is a golden target for researchers in sustainable carbon emission reduction. Here, we explore and analyze a flexible modular roadmap for the task, utilizing sequential electro-, photo-, and organocatalysis to develop a strategy for CO2 conversion using the key and elusive formaldehyde precursor of interest for sugar generation. We study the elec...
• TRPC4 regulates limbic behavior and neuronal development by stabilizing dendrite branches through actomyosin-driven integrin activation AI翻译
  作者：Jeon, Jaepyo; Moore, Travis I.; So, Insuk; Freichel, Marc; Flockerzi, Veit; Birnbaumer, Lutz; Zhu, Michael X.
  作者单位：University of Texas System; University of Texas Health Science Center Houston; Seoul National University (SNU); Ruprecht Karls University Heidelberg; German Centre for Cardiovascular Research; Universitatsklinikum des Saarlandes; Pontificia Universidad Catolica Argentina; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
  摘要：Transient Receptor Potential Canonical 4 (TRPC4) channels have been implicated in multiple neurological functions, including anxiety and sociability. TRPC4 variants were also found in patients with autism. However, the contributions of TRPC4 to neurodevelopment remain undefined. Here, we show that neurobehavioral deficits appear early in young TRPC4 knockout (Trpc4-/-) mice immediately after weaning, manifesting as alterations in multiple, limbic-related behaviors, such as nesting, marble bury...
• Structural basis for anaerobic alkane activation by a multisubunit glycyl radical enzyme AI翻译
  作者：Andorfer, Mary C.; Levitz, Talya S.; Liu, Jian; Chakraborty, Ankush; King-Roberts, Devin T.; Nweneka, Delight; Imrich, Christa N.; Drennan, Catherine L.
  作者单位：Michigan State University; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：X-succinate synthases (XSSs) are glycyl radical enzymes (GREs) that catalyze the addition of hydrocarbons to fumarate via radical chemistry, thereby activating them for microbial metabolism. To date, the only structurally characterized XSS is benzylsuccinate synthase (BSS), which functionalizes toluene. A distinct subclass ofXSSs acts on saturated hydrocarbons, which possess much stronger C(sp3)-H bonds than toluene, suggesting mechanistic and structural differences from BSS. Here, we use cryo...
• Discovery and development of an oral analgesic targeting the α2B adrenoceptor AI翻译
  作者：Toyomoto, Masayasu; Kurihara, Takashi; Nakagawa, Takayuki; Inoue, Asuka; Kimura, Ryo; Kii, Isao; Sawada, Teruo; Ogihara, Takashi; Nagayasu, Kazuki; Kishi, Takayuki; Onogi, Hiroshi; Im, Dohyun; Asada, Hidetsugu; Iwata, So; Taguchi, Jumpei; Sumida, Yuto; Yoshida, Suguru; Aoki, Junken; Hosoya, Takamitsu; Hagiwara, Masatoshi
  作者单位：Kyoto University; Kyoto University; Kyoto University; Kyoto University; Kagoshima University; Wakayama Medical University; Kyoto University; Tohoku University; Kyoto University; University of Osaka; Shinshu University; Kobe University; Kyoto University; Kyoto University; Institute of Science Tokyo; Tokyo University of Science; University of Tokyo
  摘要：Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an alpha 2A-adrenergic receptor. Hence, alpha 2-adrenergic agonists such as clonidine and dexmedetomidine exhibit analgesic and opioid-sparing effects. However, their use is restricted to hospital settings due to potential risks of acute hypertension/ hypotension and bradycardia. Here, we report that (Z)-1-(3-ethyl-5-fluorobenzo[d] thiazol-2(3H)-ylidene)propan-2-one [adrenergic inducer of analgesia (ADR...
• Mycobacteriophage-mediated gene transfer enables in vitro drug screening and in vivo tracking of Mycobacterium leprae (vol 122,e2508271122,2025) AI翻译
  作者：Das, Lahari; Chen, Bing; Rajagopalan, Saranathan; Vilcheze, Catherine; Mullholland, Claire V.; Berney, Michael; Andrews, Patrick K.; Edwards, Ashley; Lahiri, Ramanuj; Jacobs Jr, William R.