Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Dux cluster duplication ensures full activation of totipotent genes AI翻译
  作者：Lin, Meiqi; Du, Zeling; Guo, Dan; Zhang, Yiran; Dan, Jiameng
  作者单位：Kunming University of Science & Technology
  摘要：Zygotic genome activation (ZGA) confers to the mouse two-cell (2C) embryo a unique transcriptional profile characterized by transient up-regulation of many totipotency-related genes and MERVL retrotransposons. Intriguingly, those genes are duplicated and clustered in the genome during evolution, including Dux cluster, Obox, and Zscan4 family members in mice. However, the contribution and biological significance of the totipotency-related gene duplication events in early embryo development rema...
• Core dimensions of human material perception AI翻译
  作者：Schmidt, Filipp; Hebart, Martin N.; Schmid, Alexandra C.; Fleming, Roland W.
  作者单位：Justus Liebig University Giessen; Philipps University Marburg; Philipps University Marburg; Philipps University Marburg; Justus Liebig University Giessen; Max Planck Society; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
  摘要：Visually categorizing and comparing materials is crucial for everyday behavior, but what organizational principles underlie our mental representation of materials? Here, we used a large- scale data- driven approach to uncover core latent dimensions of material representations from behavior. First, we created an image dataset of 200 systematically sampled materials and 600 photographs (STUFF dataset, https://osf.io/myutc/). Using these images, we next collected 1.87 million triplet similarity j...
• Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways AI翻译
  作者：Evdokimova, Monika; Feng, Shuchen; Caobi, Allen; Moreira, Fernando R.; Jones, Dakota; Alysandratos, Konstantinos-Dionysios; Tully, Ena S.; Kotton, Darrell N.; Boyd, David F.; Banach, Bridget S.; Kirchdoerfer, Robert N.; Saeed, Mohsan; Baker, Susan C.
  作者单位：Loyola University Chicago; Boston University; Boston University; Boston University; Boston Medical Center; Boston University; Boston University; University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Santa Cruz
  摘要：Identifying conserved mechanisms used by viruses to delay host innate responses can reveal potential targets for antiviral therapeutics. Here, we investigated coronavirus nonstructural protein 15 (nsp15), which encodes a highly conserved endoribonuclease (EndoU). EndoU functions as an immune antagonist by limiting the accumulation of viral replication intermediates that would otherwise be sensed by the host. Despite being a promising antiviral target, it has been difficult to develop small- mo...
• Concomitant formation of protocells and prebiotic compounds under a plausible early Earth atmosphere (vol 122, e2413816122, 2024) AI翻译
  作者：Jenewein, Christian; Maiz-Sicilia, Aurora; Rull, Fernando; Gonzalez-Souto, Lorena; Garcia-Ruiz, Juan Manuel
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Andaluz de Ciencias de la Tierra (IACT); Universidad de Valladolid; Universidad de Cadiz
• Reply to Johnson: Holistic evaluation of ecological models in paleobiology AI翻译
  作者：Saulsbury, James G.; Parins-Fukuchi, C. Tomomi; Wilson, Connor J.; Reitan, Trond; Liow, Lee Hsiang
  作者单位：University of Oslo; University of Kansas; University of Toronto; University of Arizona; University of Oslo
• A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism AI翻译
  作者：Elling, Felix J.; Pierrel, Fabien; Chobert, Sophie-Carole; Abby, Sophie S.; Evans, Thomas W.; Reveillard, Arthur; Pelosi, Ludovic; Schnoebelen, Juliette; Hemingway, Jordon D.; Boumendjel, Ahcene; Becker, Kevin W.; Blom, Pieter; Cordes, Julia; Nathan, Vinitra; Baymann, Frauke; Lucker, Sebastian; Spieck, Eva; Leadbetter, Jared R.; Hinrichs, Kai-Uwe; Summons, Roger E.; Pearson, Ann
  作者单位：Harvard University; University of Kiel; VetAgro Sup; Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Massachusetts Institute of Technology (MIT); University of Bremen; University of Bremen; Swiss Federal Institutes of Technology Domain; ETH Zurich; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Radboud University Nijmegen; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); University of Hamburg; California Institute of Technology; California Institute of Technology; Royal Dutch Shell; Boston University
  摘要：The dominant organisms in modern oxic ecosystems rely on respiratory quinones with high redox potential (HPQs) for electron transport in aerobic respiration and photosynthesis. The diversification of quinones, from low redox potential (LPQ) in anaerobes to HPQs in aerobes, is assumed to have followed Earth's surface oxygenation similar to 2.3 billion years ago. However, the evolutionary origins of HPQs remain unresolved. Here, we characterize the structure and biosynthetic pathway of an ancest...
• An acetyltransferase moonlights as a regulator of the RNA binding repertoire of the RNA chaperone Hfq in Escherichia coli (vol 120, e2311509120, 2024) AI翻译
  作者：Luo, Xing; Zhang, Aixia; Tai, Chin-Hsien; Chen, Jiandong; Majdalani, Nadim; Storz, Gisela; Gottesman, Susan
• Ancient origin and high diversity of zymocin- like killer toxins in the budding yeast subphylum AI翻译
  作者：Heneghan, Padraic G.; Salzberg, Letal I.; Cinneide, Eoin o; Dewald, Jan A.; Weinberg, Christina E.; Wolfe, Kenneth H.
  作者单位：University College Dublin; Leipzig University
  摘要：Zymocin is a well- characterized killer toxin secreted by some strains of the yeast Kluyveromyces lactis. It acts by cleaving a specific tRNA in sensitive recipient cells. Zymocin is encoded by a killer plasmid or virus- like element (VLE), which is a linear DNA molecule located in the cytosol. We hypothesized that a tRNA- cleaving toxin similar to zymocin may have caused the three parallel changes to the nuclear genetic code that occurred during yeast evolution, in which the codon CUG became ...
• Bioinspired energy-free temperature gradient regulator for significant enhancement of thermoelectric conversion efficiency AI翻译
  作者：Tan, Haohan; Zhao, Yuqian; Jin, Peng; Xu, Xiang; Zhou, Xinchen; Marchesoni, Fabio; Huang, Jiping
  作者单位：Fudan University; Fudan University; Harbin Institute of Technology; Shanghai Jiao Tong University; Tongji University; University of Camerino
  摘要：Enhancing thermoelectric conversion efficiency (TCE) is pivotal for advancing global energy conservation and emission reduction initiatives. Traditional approaches primarily focus on microscopic strategies such as bandgap engineering, chemical potential adjustments, and entropy engineering. However, these methods face substantial limitations in practical applications due to challenging material property requirements. Additionally, the efficiencies achieved remain modest, constrained by the int...
• The unique reactivity of EKODE lipid peroxidation products allows in vivo detection of inflammation AI翻译
  作者：Shi, Chuan; Eskandari, Roozbeh; Zhang, Jianye; Zhang, Guofang; Li, Li; Hawkins, Deandrea; Zhu, Xiongwei; Tochtrop, Gregory P.
  作者单位：University System of Ohio; Case Western Reserve University; Duke University; University System of Ohio; Case Western Reserve University
  摘要：Lipid peroxidation is a complex biochemical process associated with oxidative stress, and its products play crucial roles in cellular signaling and the pathophysiology of many diseases. Among the diverse array of lipid peroxidation (LPO) products, epoxyketoocta-decenoic acids (EKODEs) have emerged as intriguing molecules with potential impacts on inflammatory diseases. EKODEs arise from linoleic acid reacting with reactive oxygen and nitrogen species present during inflammation. A hallmark of ...